Cytotoxic constituents of propolis inducing anticancer effects: a review

Objectives Propolis is a honeybee product used extensively in traditional medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer effects. Propolis exhibits a broad spectrum of biological activities because it is a complex mixture of natural substances. In this review, the antitumour effects of propolis extracts and its constituents (e. g. flavonoids, terpenes and caffeic acid phenethyl ester) are discussed.Key findings The effect of propolis on experimental carcinogenesis is discussed, as well as its possible mechanisms of action against tumours, involving apoptosis, cell cycle arrest and interference on metabolic pathways. Propolis seems to be efficient against different tumour cells both in vitro and in vivo, which suggests its potential in the development of new anticancer drugs.Summary Propolis extracts may be important economically and would allow a relatively inexpensive cancer treatment. Preclinical investigations are needed to further elucidate the benefits of propolis and its antitumour properties.

Bathymetric distribution of the shrimp Rimapenaeus constrictus (Stimpson, 1874) (Decapoda, Penaeidae) in two locations off the southeastern Brazilian coast

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Biodegradation of blend films PVA/PVC, PVA/PCL in soil and soil with landfill leachate

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselhos de saúde: conhecimento sobre as ações de saúde

O Conselho de Saúde - órgão colegiado composto por representantes do governo, profissionais prestadores de serviço da saúde e usuários - atua na formação de estratégias e no controle da execução da política de saúde na instância correspondente, inclusive nos aspectos econômicos e financeiros, e tem suas decisões homologadas pelo chefe do Poder Executivo. Este artigo avalia o perfil dos conselhos municipais de saúde de cinco municípios de pequeno porte do estado de São Paulo, através da análise do conhecimento de seus membros.

HUMAN SYNGAMOSIS - 2 CASES OF CHRONIC COUGH CAUSED BY MAMMOMONOGAMUS-LARYNGEUS

Parasites of the genus Mammomonogamus may occasionally affect the human respiratory tract, causing human syngamosis. We describe two cases of chronic unproductive cough caused by Mammomonogamus laryngeus that occurred in the state of São Paulo, Brazil. Some aspects related to human parasitism, diagnostic approach, and treatment are discussed.

Effects of biofertilizer rates on the structural, morphogenetic and productive characteristics of Piata grass

The objective of this study was to investigate the influence of different levels of biofertilizers from cattle and swine manure on the structural, morphogenetic and productive characteristics of Brachiaria brizantha cv. Piata. The experiment was arranged in a completely randomized factorial design with split plots. The plots were defined by eight treatments: two biofertilizers (cattle and swine), four levels (0, 100, 200 and 300 kg N.ha(-1)) and subplots by four different cutting periods. The cutting for plant uniformity was performed at 45 days after sowing at 15 cm above the soil surface. The biofertilizeres were applied in a single level, after the cutting of plants, in rates of 0, 0.23 and 0.19, 0.45 and 0.38, 0.68 and 0.57 liters pot(-1) for the biofertilizers from cattle and swine manure, respectively. These rates were also equivalent to levels of 0, 100, 200 and 300 kg N.ha(-1). There was no significant difference between the types of biofertilizers as there was no interaction between them and the different levels, hence both biofertilizers could be applied without any loss of nutrient intake by the plants used in this experiment. There was a significant difference between the production of green and dry matter, the leaf appearance rate, phyllochron, leaf and pseudostem elongation rates, number of green leaves, final leaf length, number and weight of tillers, according to the increase of nitrogen rates, following linear prediction model. Effect of the cutting periods was also observed, once the plants harvested during the summer presented greater performance of structural and morphogenetic characteristics.

Escépticos, narcisos, rebeldes: 6 estudios sobre la juventud

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Mujer y trabajo en las reformas estructurales latinoamericanas durante las décadas de 1980 y 1990

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Desarrollo frutícola y forestal en Chile y sus derivaciones sociales

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Desarrollo frutícola en Chile y sus transformaciones sociales

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Fomento de la actividad forestal y su impacto sobre el desarrollo rural en Chile

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La estrategia cubana de la vuelta al campo: anhelos y opciones de los jóvenes rurales

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Diapriinae (Hymenoptera, Diapriidae) da estação ecológica de Jatí, no município de Luiz Antônio

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV