Scalable and Efficient Configuration of TimeDivision Multiplexed Resources

Consumer-electronics systems are becoming increasingly complex as the number of integrated applications is growing. Some of these applications have real-time requirements, while other non-real-time applications only require good average performance. For cost-efficient design, contemporary platforms feature an increasing number of cores that share resources, such as memories and interconnects. However, resource sharing causes contention that must be resolved by a resource arbiter, such as Time-Division Multiplexing. A key challenge is to configure this arbiter to satisfy the bandwidth and latency requirements of the real-time applications, while maximizing the slack capacity to improve performance of their non-real-time counterparts. As this configuration problem is NP-hard, a sophisticated automated configuration method is required to avoid negatively impacting design time. The main contributions of this article are: 1) An optimal approach that takes an existing integer linear programming (ILP) model addressing the problem and wraps it in a branch-and-price framework to improve scalability. 2) A faster heuristic algorithm that typically provides near-optimal solutions. 3) An experimental evaluation that quantitatively compares the branch-and-price approach to the previously formulated ILP model and the proposed heuristic. 4) A case study of an HD video and graphics processing system that demonstrates the practical applicability of the approach.

Giant warts in a kidney transplant patient: regression with sirolimus.

Purpose: Recent reports have suggested that intraabdominal postoperative infection is associated with higher rates of overall and local recurrence and cancer-specific mortality. However, the mechanisms responsible for this association are unknown. We hypothesized that the greater inflammatory response in patients with postoperative intraabdominal infection is associated to an increase in local and systemic angiogenesis. Methods: We designed a prospective cohorts study with matched controls. Patients with postoperative intra-abdominal infection (abscess and/or anastomotic leakage) (group 1; n=17) after elective colorectal cancer resection operated on for cure were compared to patients with an uncomplicated postoperative course (group 2; n=17). IL-6 and VEGF levels were determined by ELISA in serum and peritoneal fluid at baseline, 48 hours and postoperative day 4 or at the time the peritoneal infection occurred. Results: No differences were observed in age, gender, preoperative CEA, tumor stage and location and type of procedure performed. Although there were no differences in serum IL-6 levels at 48 hours, this pro-inflammatory cytokine was higher in group 1 on postoperative day 4 (group 1: 21533 + 27900 vs. group 2: 1130 + 3563 pg/ml; p < 0.001). Serum VEGF levels were higher in group 1 on postoperative day 4 (group 1: 1212 + 1025 vs. group 2: 408 + 407 pg/ml; p < 0.01). Peritoneal fluid VEGF levels were also higher in group 1 at 48 hours (group 1: 4857 + 4384 vs. group 2: 630 + 461 pg/ml; p < 0.001) and postoperative day 4 (group 1: 32807 + 98486 vs. group 2: 1002 + 1229 pg/ml; p < 0.001). A positive correlation between serum IL-6 and VEGF serum levels was observed on postoperative day 4 (r=0.7; p<0.01). Conclusions: These results suggest that not only the inflammatory response but also the angiogenic pathways are stimulated in patients with intra-abdominal infection after surgery for colorectal cancer. The implications of this finding on long-term follow-up need to be evaluated.

Quality control and conduct of genome-wide association meta-analyses.

Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta-level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.

IV thrombolysis and renal function.

OBJECTIVE: To investigate the association of renal impairment on functional outcome and complications in stroke patients treated with IV thrombolysis (IVT). METHODS: In this observational study, we compared the estimated glomerular filtration rate (GFR) with poor 3-month outcome (modified Rankin Scale scores 3-6), death, and symptomatic intracranial hemorrhage (sICH) based on the criteria of the European Cooperative Acute Stroke Study II trial. Unadjusted and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Patients without IVT treatment served as a comparison group. RESULTS: Among 4,780 IVT-treated patients, 1,217 (25.5%) had a low GFR (<60 mL/min/1.73 m(2)). A GFR decrease by 10 mL/min/1.73 m(2) increased the risk of poor outcome (OR [95% CI]): (ORunadjusted 1.20 [1.17-1.24]; ORadjusted 1.05 [1.01-1.09]), death (ORunadjusted 1.33 [1.28-1.38]; ORadjusted 1.18 [1.11-1.249]), and sICH (ORunadjusted 1.15 [1.01-1.22]; ORadjusted 1.11 [1.04-1.20]). Low GFR was independently associated with poor 3-month outcome (ORadjusted 1.32 [1.10-1.58]), death (ORadjusted 1.73 [1.39-2.14]), and sICH (ORadjusted 1.64 [1.21-2.23]) compared with normal GFR (60-120 mL/min/1.73 m(2)). Low GFR (ORadjusted 1.64 [1.21-2.23]) and stroke severity (ORadjusted 1.05 [1.03-1.07]) independently determined sICH. Compared with patients who did not receive IVT, treatment with IVT in patients with low GFR was associated with poor outcome (ORadjusted 1.79 [1.41-2.25]), and with favorable outcome in those with normal GFR (ORadjusted 0.77 [0.63-0.94]). CONCLUSION: Renal function significantly modified outcome and complication rates in IVT-treated stroke patients. Lower GFR might be a better risk indicator for sICH than age. A decrease of GFR by 10 mL/min/1.73 m(2) seems to have a similar impact on the risk of death or sICH as a 1-point-higher NIH Stroke Scale score measuring stroke severity.

Efectos del Fenómeno «El Niño» sobre el Fitoplancton

El fenómeno «El Niño» (EN) que se caracteriza por la presencia de aguas de altas temperaturas y salinidades mayores de 35%0 o menos de 34,8%0 , de acuerdo a la masa de agua que ingresa, produce cambios significativos en la comunidad fitoplanctónica tanto en la abundancia, distribución, así como en la composición específica. La biomasa planctónica en la costa peruana normal­ mente es alta, presentando volúmenes promedios ma­ yores de 3 mi m -3, pero cuando se producen alteraciones como el fenómeno EN encontramos los volúmenes promedio bajos, menores que 1 mi m -3 . En cuanto a la distribución, el fitoplancton en épocas normales está constituido principalmente por las diatomeas, las mismas que se distribuyen a lo largo de la costa y en su mayoría hasta las 60 millas, afuera de ella el fitoplancton está representado por los dinotlagela­ dos; mientras que, en épocas consideradas como EN las diatomeas se distribuyen dentro de las 10 millas y los dinotlagelados propios de aguas calientes se acercan generalmente hasta las 10 millas de la costa. La composición del fitoplancton también varía. En años considerados normales la predominancia está dada por diatomeas como : Schroderella delicatula, Thalassionema nitzschioides, Skeletonema costatum, Asterionella japonica y Chaetoceros y los dinotlagela­ dos: Ceratiumfurca, Protoperidinium obtusum, etc. En épocas consideradas anormales se presentan otras especies como : Thalassiosira partheneia, Rhizosolenia temperei, Rh. castracanei, Streptotheca thamensis y Biddulphia sinensis ; dentro de los dinotlagelados : Cera­ tium breve, C. extensum, C. longirostrum, C. trichoceros, Ceratocorys horrida, Ornithocercus magnificus, O. qua­ dratus, O. steinii y Protoperidinium elegans.

RECUEIL DES ŒUVRES POÉTIQUES de Jehan Molinet. Ms. in-fol. sur papier de 201 f., demi-rel. v. f, tr. r. (Rel. du XVIIIe siècle.)

Complainte (La) de Grece

L'Écho de Paris

1887/07/12 (Numéro 1212).

Recueil de chartes de commune.

Contient : Châteauvillain ; Troyes ; Nogaro en Armagnac ; Narbonne ; La Beuvrière (cf. fol. 73) ; Reims ; Troyes ; Beaumont ; Châteauvillain (1236 ; cf. fol. 2) ; La Chapelle [d'Angillon] ; Joigny ; Lorris ; Dixmont ; Montargis ; Barcelone (cf. fol. 149) ; Selens et Saint-Aubin ; La Beuvrière (cf. fol. 14) ; Chaumont ; Saint-Bris ; Saint-Laurent-sur-Barenjon ; Voisines ; Le Moulinet ; Barlieu ; Crespy [-en-Valois] ; Montdidier ; Laon ; Soissons ; Abbeville ; Compiègne ; Saint-Quentin ; Corbie ; Saint-Josse-sur-Mer ; La Fère ; Beauvais ; Nanteuil ; Courmelles ; Breteuil ; Beaumont-en-Argonne ; Chaumont ; Saint-Omer ; Vaux près Mouzon ; Vaux, Saconin, Mercin ; Chacrise ; Tournai ; Crandelain, etc ; Ambleteuse ; Morsain, etc ; Mantes ; Ferrières ; Aizy ; Pargny ; Saint-Riquier ; Soissons ; Saint-Martin d'Issoudun (cf. fol. 182) ; Rouen ; Dreux ; Meaux ; Reims ; Chablis ; Chatillon-sur-Seine ; Sens ; Auxerre ; Cerny ; Dixmont ; Étampes ; Orléans ; Bourges ; Issoudun (cf. fol. 148) ; Beaufort-en-Vallée ; La Rochelle ; Villefranche [d'Allier] ; Montauban ; Nevers ; Castres ; Toulouse ; Habitants de la Terre d'Albigeois ; Aigues-Mortes ; Lorrez-le-Bocage ; Le Puy ; Saint-Céré ; Barcelone ; Chatillon-sur-Marne ; Raucourt et Héraucourt ; Mézières ; Chatillon-sur-Marne ; Saint-Hellier ; Coutumes d'Anjou et du Maine ; Ervy-le-Chatel ; Cerres, Montceaux, Chaussepierre ; Notice sur un ms. de Chroniques françaises, de la bibliothèque de Colbert (= Duchesne 79)

Français 834

Contient : 1° « Doctrinal LE SAUVAGE » ; 2° « La Dietez du corps et de l'ame », par « PIERRE » ; 3° « L'Evre du jour » ; 4° « La Translacion monseigneur saint Jaque », de « CALIXTE » [II], traduction exécutée en 1212, à la demande d'Yolande, comtesse de Saint-Pol, par « PIERRE » ; 5° « L'Istoire Charlemainne, comment il conquist Espaigne et la sainte terre de promission en laquelle est Jherusalem... », ou la Chronique de Turpin, traduction de « PIERRE » ; 6° « Le Livre de moralitez des filosophes », ou Livre de Sénèque ; 7° « Li Bestiaires... que Phisiologes, uns bons clers d'Athenes, traita, et Jehans Crisostonus en choisi en les natures des bestes et des oisiaus », traduction de « PIERRE » ; 8° « Le Testament mestre JEHAN de Mehun » ; 9° « Le Livre du Renclus de Moliens » ; 10° « Le Chapitre de charité », du même ; 11° « Le Mireoers de la vie et de la mort », composé en 1366 par « ROBERT DE L'ORME » ; 12° « La Devision de la nef du monde » ; 13° « Des quinze Signes qui doivent venir avant la fin du monde » ; 14° « La Lettre que Prestre Jehan envoya à l'empereur Fedric de Contantinoble » ; 15° « Le Purgatoire que Nostre Seigneur Jhesu Crist monstra à saint Patrix » ; 16° Les Vertus de l'eau Salemonde

Gerencia de recursos humanos auditorias telefónicas

Banco del conocimiento

Bleachers in old Chapman Stadium, Chapman University, Orange, California

Chapman Stadium shortly before demolition, Chapman University, Orange, California, 2005. This stadium was originally constructed in 1934 by Orange Union High School, Orange, California. Ownership transferred to Chapman College in 1954. It was re-named in 2

THE PREVALENCE AND PREDICTION OF PULMONARY FIBROSIS IN AN

This thesis describes an ancillary project to the Early Diagnosis of Mesothelioma and Lung Cancer in Prior Asbestos Workers study and was conducted to determine the effects of asbestos exposure, pulmonary function and cigarette smoking in the prediction of pulmonary fibrosis. 613 workers who were occupationally exposed to asbestos for an average of 25.9 (SD=14.69) years were sampled from Sarnia, Ontario. A structured questionnaire was administered during a face-to-face interview along with a low-dose computed tomography (LDCT) of the thorax. Of them, 65 workers (10.7%, 95%CI 8.12—12.24) had LDCT-detected pulmonary fibrosis. The model predicting fibrosis included the variables age, smoking (dichotomized), post FVC % splines and post- FEV1% splines. This model had a receiver operator characteristic area under the curve of 0.738. The calibration of the model was evaluated with R statistical program and the bootstrap optimism-corrected calibration slope was 0.692. Thus, our model demonstrated moderate predictive performance.