SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion

Migrating fibroblasts undergo contact inhibition of locomotion (CIL), a process that was discovered five decades ago and still is not fully understood at the molecular level. We identify the Slit2-Robo4-srGAP2 signaling network as a key regulator of CIL in fibroblasts. CIL involves highly dynamic contact protrusions with a specialized actin cytoskeleton that stochastically explore cell-cell overlaps between colliding fibroblasts. A membrane curvature-sensing F-BAR domain pre-localizes srGAP2 to protruding edges and terminates their extension phase in response to cell collision. A FRET-based biosensor reveals that Rac1 activity is focused in a band at the tip of contact protrusions, in contrast to the broad activation gradient in contact-free protrusions. SrGAP2 specifically controls the duration of Rac1 activity in contact protrusions, but not in contact-free protrusions. We propose that srGAP2 integrates cell edge curvature and Slit-Robo-mediated repulsive cues to fine-tune Rac1 activation dynamics in contact protrusions to spatiotemporally coordinate CIL.

Maccabaean lamp ; Menorah [Illustration] : Frankfurt a. M. 1730 ; getriebenes Silber

Scan von Monochrom-Mikroform

Temperature controlled light-emitting diode lamp for photovoltaic rural applications

In recent years, interest in light-emitting diode (LED) lighting has been growing because of its high efficacy, lifetime and ruggedness. This paper proposes a better adaptation of LED lamps to the technical requirements of photovoltaic lighting domestic systems, whose main quality criteria are reliability and that behave as voltage power supplies. As the key element of reliability in LED lamps is temperature, a solution is proposed for driving LED lamps using voltage sources, such as photovoltaic system batteries, with a control architecture based on pulse width modulation signal that regulates the current applied according to the LED lamp temperature. A prototype of the LED lamp has been implemented and tested to show its good performance at different temperatures and at different battery voltages.

Aladdin's Magic Lamp: Developing Methods for Calibration and Geolocation Accuracy Assessment of the DMSP OLS

Nighttime satellite imagery from the Defense Meteorological Satellite Program (DMSP) Operational Linescan System (OLS) has a unique capability to observe nocturnal light emissions from sources including cities, wild fires, and gas flares. Data from the DMSP OLS is used in a wide range of studies including mapping urban areas, estimating informal economies, and estimating urban populations. Given the extensive and increasing list of applications a repeatable method for assessing geolocation accuracy, performing inter-calibration, and defining the minimum detectable brightness would be beneficial. An array of portable lights was designed and taken to multiple field sites known to have no other light sources. The lights were operated during nighttime overpasses by the DMSP OLS and observed in the imagery. A first estimate of the minimum detectable brightness is presented based on the field experiments conducted. An assessment of the geolocation accuracy was performed by measuring the distance between the GPS measured location of the lights and the observed location in the imagery. A systematic shift was observed and the mean distance was measured at 2.9km. A method for in situ radiance calibration of the DMSP OLS using a ground based light source as an active target is presented. The wattage of light used by the active target strongly correlates with the signal measured by the DMSP OLS. This approach can be used to enhance our ability to make inter-temporal and inter-satellite comparisons of DMSP OLS imagery. Exploring the possibility of establishing a permanent active target for the calibration of nocturnal imaging systems is recommended. The methods used to assess the minimum detectable brightness, assess the geolocation accuracy, and build inter-calibration models lay the ground work for assessing the energy expended on light emitted into the sky at night. An estimate of the total energy consumed to light the night sky globally is presented.

The development and structure of the U.S. electric lamp industry : staff report of the Federal Trade Commission /

Cover title: Staff report on the development and structure of the U.S. electric lamp industry.

Driver perception of just-noticeable differences of automotive signal lamp intensities. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Mosque Lamp

Glass, Islamic, Mamluk; 10 5/16 in. x 8 17/64 in.; glass, brownish; blown, folded foot, applied handles; enameled and gilded

Mosque Lamp, from the Suleymaniye Mosque

Pottery, Turkey, Ottoman; 1 ft. 6 31/32 in. x 1 ft. 13/32 in.; glazed fritware, polychrome underglazed painted

Modified double-slit interferometer for shock-wave investigations.

"This work was carried out as part of Project SQUID which is supported by the Office of Naval Research under Contract Nonr-1858 (25)."

The lamp in the desert,

Mode of access: Internet.

The lamp of poor souls, and other poems,

"The greater number of these poems appeared in an earlier volume, "The drift of pinions'."

Round the red lamp : being facts and fancies of medical life /

Behind the times -- His first operation -- A straggler of '15 -- The third generation -- A false start -- The curse of Eve -- Sweethearts -- A physiologist's wife -- The case of Lady Sannox -- A question of diplomacy -- A medical document -- Lot no. 249 -- The Los Amigos fiasco -- The doctors of Hoyland -- The surgeon talks.

Aladdin, or, The wonderful lamp : a piece of oriental extravaganze in one act /

Mode of access: Internet.

The lamp.

"New series of the Book buyer."

Mosque Lamp

Glass, Islamic, Mamluk; H: 1 ft. 63/64 in.; glass, gilt and enameled