The new Lancashire gazetteer; or, Topographical dictionary, containing an accurate description of the several hundreds, boroughs, market towns, parishes, townships, and hamlets, in the county palatine of Lancaster ...

Mode of access: Internet.

The history and antiquities of the county palatine of Durham.

Errors in paging, v. 3: 337-344 repeated in numbering.

A full and detailed account of the Guild Merchant of Preston, in the county palatine of Lancaster, as celebrated in the year 1842.

Goldsmiths'-Kress no. 33098.

Lancashire and Cheshire, past and present: a history and a description of the palatine counties of Lancaster and Chester, forming the North-western division of England, from the earliest ages to the present time (1867).

Added t.-p., engr.

A history of Herkimer County : including the upper Mohawk Valley, from the earliest period to the present time ; with a brief notice of the Iroquois Indians, the early German tribes, the Palatine immigrations into the colony of New York, and biographical sketches of the Palatine families, the patentees of Burnetsfield in the year 1725 ; and also biographical notices of the most prominent public men of the county ; with important statistical information /

Includes index.

Authentic records of the guild merchant of Preston, in the county palatine of Lancaster, in the year 1822; with an introduction, containing an historical dissertation on the origin of guilds; and a relation of all the different celebrations of the guilda mercatoria, of Preston, of which any records remain.

Mode of access: Internet.

Considerations sur les montagnes volcaniques : mémoire lu dans une séance de l'Académie électorale des sciences et belles lettres de Mannheim le V. novembre MDCCLXXXI : a l'occasion de la St. Charles, fête de S.A.S.E. Palatine et de Baviere Charles Theodore fondateur et protecteur de cette académie /

1 fold. plate and one fol. table follow text.

The history of the county palatine and city of Chester;

King's Vale royall was written by William Smith and William Webb, and was published, together with Samuel Lee's Chronicon cestrense and J. Chaloner's Short treatise of the Isle of Man, by David King. In the present work, Chaloner's Isle of Man has been omitted.

Correspondance complète de madame duchesse d'Orléans née princesse palatine, mère du régent;

Extracts of the correspondence. First published by Wolfgang Menzel, in Stuttgart, 1843; Brunet's translation of Menzel's edition first appeared in 1853. It is here completely revised and increased by the addition of fragments published in 1788 by m. de Praun and by other material, part of which was previously unpublished.--cf. Avertissement.

The period of mourning. Disposed into sixe visions. In memorie of the late prince. Together with nuptiall hymnes, in honour of this happy marriage betweene .. Frederick, Count Palatine of the Rhene, and ... Elizabeth onely daughter to our soueraigne, his maiestie. Also thr manner of the solemnization of the marriage at White-Hall ...

Mode of access: Internet.

The visitation of the county palatine of Lancaster, made in the year 1664-5 /

Twenty-eighth report of the Council of the Chetham society, 1870/71, and list of members, 1871/72, appended to v. 1.

Registrum Palatinum dunelmense. The register of Richard de Kellawe, lord palatine and bishop of Durham, 1311-1316.

Register of Bishop Bury: v. 3, p. 208-523.

Portfolio of fragments relative to the history and antiquities, topography and genealogies of the county palatine and duchy of Lancaster ...

"Substantially a reprint of the second edition of 1824."

A prospective trial of short-fractionation radiotherapy for the palliation of liver metastases

The purpose of this study was to prospectively examine the effectiveness and tolerability of a simple radiotherapy technique for the palliation of symptomatic liver metastases. Twenty-eight patients with symptomatic liver metastases were enrolled from seven centres, and received targeted (partial or whole) liver irradiation consisting of 10 Gy in two fractions over 2 days. Symptoms at baseline were hepatic pain (27 patients), abdominal distension (19), night sweats (12), nausea (18) and vomiting (eight). Twenty-two patients (76%) had failed previous treatment with chemotherapy, hormonal therapy and/or high-dose steroids. Symptoms and potential toxicities were prospectively assessed at the time of treatment, then 2, 6 and 10 weeks later. Individual symptom response rates were 53−66% at 2 weeks. Partial or complete global symptomatic responses were noted in 15 patients (54%) overall. The treatment was well tolerated with two patients (7%) experiencing grade 3 toxicity (one vomiting and one diarrhoea); however, four patients reported temporary worsening of pain shortly after treatment. This simple and well-tolerated treatment achieves useful palliation.

Randomized trial of 8 Gy in 1 versus 20 Gy in 5 fractions of radiotherapy for neuropathic pain due to bone metastases (Trans-Tasman Radiation Oncology Group, TROG 96.05)

Background and purpose: Despite numerous randomized trials investigating radiotherapy (RT) fractionation schedules for painful bone metastases, there are very few data on RT for bone metastases causing pain with a neuropathic component. The Trans-Tasman Radiation Oncology Group undertook a randomized trial comparing the efficacy of a single 8 Gy (8/1) with 20 Gy in 5 fractions (20/5) for this type of pain. Materials and methods: Eligible patients had radiological evidence of bone metastases from a known malignancy with no change in systemic therapy within 6 weeks before or anticipated within 4 weeks after RT, no other metastases along the distribution of the neuropathic pain and no clinical or radiological evidence of cord/cauda equina compression. All patients gave written informed consent. Primary endpoints were pain response within 2 months of commencement of RT and time to treatment failure (TTF). The hypothesis was that 8/1 is at least as effective as 20/5 and the planned sample size was 270 patients. Results: Between February 1996 and December 2002, 272 patients were randomized (8/1:20/5 = 137:135) from 15 centres (Australia 11, New Zealand 3, UK 1). The commonest primary cancers were lung (31%), prostate (29%) and breast (8%); index sites were spine (89%), rib (9%), other (2%); 72% of patients were males and the median age was 67 (range 2989). The median overall survival (95% CI) for all randomized patients was 4.8 mo (4.2-5.7 mo). The intention-to-treat overall response rates (95% Cl) for 8/1 vs 20/5 were 53% (45-62%) vs 61% (53-70%), P = 0.18. Corresponding figures for complete response were 26% (18-34%) vs 27% (19-35%), P = 0.89. The estimated median TTFs (95% CI) were 2.4 mo (2.0-3.3 mo) vs 3.7 mo (3.1-5.9 mo) respectively. The hazard ratio (95% Cl) for the comparison of TTF curves was 1.35 (0.99-1.85), log-rank P = 0.056. There were no statistically significant differences in the rates of re-treatment, cord compression or pathological fracture by arm. Conclusions: 8/1 was not shown to be as effective as 20/5, nor was it statistically significantly worse. Outcomes were generally poorer for 8/1, although the quantitative differences were relatively small. (c) 2004 Elsevier Ireland Ltd. All rights reserved.