Las obras de Hippocrates mas selectas /

Contiene: Libro primero de las epidemias.

Las obras de Hippocrates mas selectas /

Contiene: Libro segundo de las epidemias.

Jakob Bohme's Sammtliche werke /

Reprint of 1831-1847 edition.

Kriegsbriefe der Familie Wimmel.

Mode of access: Internet.

Der vollständige conditor, schweitzerbäcker und destillateur.

Vol. 1 has added t.-p.: Le refraicheur, oder ausführliche und deutliche Unterweisung zur Verfertigung allerlei Arten gefrornen und andrer Erfrischungen ... Von Christian Gustav Haupt ... Von neuem und mit Zusätzen hrsg. von Franz Xaver Czerdelinczkj ...

Deutscher Liederhort. Auswahl der vorzüglicheren deutschen Volkslieder, nach Wort und Weise aus der Vorzeit und Gegenwart

"Quellen-verzeichniss": v. 1, p. [xvii]-lx.

Die volksgewerbschule, ihre sozialwirtschaftliche aufgabe, ihre methode und naturgemässe gestaltung.

Mode of access: Internet.

Beschreibung der drey principien göttliches wesens ...

Mode of access: Internet.

Das livländische bankwesen in vergangenheit und gegenwart.

Appeared in part as author's inaugural dissertation, Würzburg, 1908 (181 p.) under title: "Das ältere bankwesen Livlands."

Waldeckische Reformationsgeschichte.

Mode of access: Internet.

Heilige Schrift und Kritik : ein Beitrag zur Lehre von der Heiligen Schrift, insonderheit Alten Testamentes /

Mode of access: Internet.

Münchener Beiträge zur romanischen und englischen Philologie.

Vols. 1-3 ed. by Hermann Breymann; v. 4-11 by H. Breymann and E. Koeppel; v. 12-54 by H. Breymann and J. Schick.

Uebungsbuch im rechen /

Mode of access: Internet.

Double-heater-wire circuits and heat-and-moisture exchangers and the risk of ventilator-associated pneumonia

Objective: To compare the incidence of ventilator-associated pneumonia (VAP) in patients ventilated in intensive care by means of circuits humidified with a hygroscopic heat-and-moisture exchanger with a bacterial viral filter (HME) or hot-water humidification with a heater wire in both inspiratory and expiratory circuit limbs (DHW) or the inspiratory limb only (SHW). Design: A prospective, randomized trial. Setting: A metropolitan teaching hospital's general intensive care unit. Patients: Three hundred eighty-one patients requiring a minimum period of mechanical ventilation of 48 hrs. Interventions: Patients were randomized to humidification with use of an HME (n = 190), SHW (n = 94), or DHW (n = 97). Measurements and Main Results. Study end points were VAP diagnosed on the basis of Clinical Pulmonary Infection Score (CPIS) (1), HME resistance after 24 hrs of use, endotracheal tube resistance, and HME use per patient. VAP occurred with similar frequency in all groups (13%, HME; 14%, DHW; 10%, SHW; p = 0.61) and was predicted only by current smoking (adjusted odds ratio [AOR], 2.1; 95% confidence interval [CI], 1.1-3.9; p =.03) and ventilation days (AOR, 1.05; 95% Cl, 1.0-1.2; p =.001); VAP was less likely for patients with an admission diagnosis of pneumonia (AOR, 0.40; 95% Cl, 0.4-0.2; p =.04). HME resistance after 24 hrs of use measured at a gas flow of 50 L/min was 0.9 cm H2O (0.4-2.9). Endotracheal tube resistance was similar for all three groups (16-19 cm H2O min/L; p =.2), as were suction frequency, secretion thickness, and blood on suctioning (p =.32, p =.06, and p =.34, respectively). The HME use per patient per day was 1.13. Conclusions: Humidification technique does not influence either VAP incidence or secretion characteristics, but HMEs may have air-flow resistance higher than manufacturer specifications after 24 hrs of use.

Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterisation

Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large-scale manufacture. Current literature has primarily focused on the preparation and characterization of novel cocrystals typically containing only the drug and coformer, leaving the subsequent formulation less explored. In this paper we propose, for the first time, the use of hot melt extrusion for the mechanochemical synthesis of pharmaceutical cocrystals in the presence of a meltable binder. In this approach, we examine excipients that are amenable to hot melt extrusion, forming a suspension of cocrystal particulates embedded in a pharmaceutical matrix. Using ibuprofen and isonicotinamide as a model cocrystal reagent pair, formulations extruded with a small molecular matrix carrier (xylitol) were examined to be intimate mixtures wherein the newly formed cocrystal particulates were physically suspended in a matrix. With respect to formulations extruded using polymeric carriers (Soluplus and Eudragit EPO, respectively), however, there was no evidence within PXRD patterns of either crystalline ibuprofen or the cocrystal. Importantly, it was established in this study that an appropriate carrier for a cocrystal reagent pair during HME processing should satisfy certain criteria including limited interaction with parent reagents and cocrystal product, processing temperature sufficiently lower than the onset of cocrystal Tm, low melt viscosity, and rapid solidification upon cooling.