164 resultados para fri lek.
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Mode of access: Internet.
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Mode of access: Internet.
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Established in 1960 by Grace L. Bigby and Demaris E.Cash, Ann Arbor's exclusive resale shop. Everything is sold on consignment. Sellers pay a nominal membership fee to dispose their merchandise incognito. Buyers delight in browsing among these "treasures." 529 Detroit St. - Ann Arbor Michigan NO 2-1363. Estate Sales Our Speciality . Mon. thru Sat. 9-5:30 Mon. & Fri. eves. 'til 9
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Established in 1960 by Grace L. Bigby and Demaris E.Cash. Ann Arbor's exclusive resale shop. Everything is sold on consignment. Sellers pay a nominal membership fee to dispose their merchandise incognito. Buyers delight in browsing among these "treasures." 529 Detroit St. - Ann Arbor Michigan NO 2-1363. Estate Sales Our Speciality . Mon. thru Sat. 9-5:30 Mon. & Fri. eves. 'til 9
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Part II "2e geheel herziene druk" has subtitle: Determineertabellen en beschrijving der soorten.
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Många ställer sig kritiska till mobiloperatörerna Tre och Telias kampanjer då de sägs utmana nätneutraliteten på internet. Journalisten och opinionsledaren Emanuel Karlsten jobbar aktivt med frågan och menar att dessa initiativ är ett kliv i fel riktning. Tidigare studier visar att en reglering kring begreppet nätneutralitet inte varit nödvändig då existerande bestämmelser varit nog. Den pågående debatten i USA skapade tendenser och oro för vart utvecklingen var på väg vilket fick EU att ta ställning i frågan om vad framtida internet ska innebära. Syftet med denna studie är att undersöka hur begreppet nätneutralitet definieras och sägs tillämpas av ett antal aktörer som är aktiva i den svenska debatten kring Tres och Telias reklamkampanjer “Nu släpper vi musiken fri!” och “#Hatahat” som drivande nyhetshändelser. I studien har empiriska materialet samlats in genom kvalitativa intervjuer med respondenter som ansågs vara relevanta för studien genom sin yrkesutövning. Det beskrivande intervjumaterialet kompletteras av en argumentationsanalys. Syftet är att skapa en större och djupare förståelse för argumentationen i debatten om nätneutralitet och Tres och Telias kampanjer. I studien genomfördes även en pilotstudie i form av enkäter, med syfte att få en överblick över människors kunskap kring begreppet nätneutralitet. Många anser att förordningen inom nätneutralitet är slarvigt gjord men den innehåller delar av olika aspekter, det finns ingen entydig definition av nätneutralitet och därför kan begreppet vara svårt att förstå. Detta har orsakat en viss svårighet med insamling av data i form av intervjuer och sammanställning av denna studie. Den nya EU-förordningen säger att mobiloperatörer får förpacka sina erbjudanden till kunderna för att utforma intressanta erbjudanden, så länge man gör det inom ramen så är erbjudandet en affärsmetod. Frågan som består är vart gränsen för diskriminering går? Det handlar om en komplicerad tolkningsfråga och det är Post- och telestyrelsens ansvar att sammanställa förordningen och se till att mobiloperatörer följer dess riktlinjer.
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Stabilizing selection has been predicted to change genetic variances and covariances so that the orientation of the genetic variance-covariance matrix (G) becomes aligned with the orientation of the fitness surface, but it is less clear how directional selection may change G. Here we develop statistical approaches to the comparison of G with vectors of linear and nonlinear selection. We apply these approaches to a set of male sexually selected cuticular hydrocarbons (CHCs) of Drosophila serrata. Even though male CHCs displayed substantial additive genetic variance, more than 99% of the genetic variance was orientated 74.9degrees away from the vector of linear sexual selection, suggesting that open-ended female preferences may greatly reduce genetic variation in male display traits. Although the orientation of G and the fitness surface were found to differ significantly, the similarity present in eigenstructure was a consequence of traits under weak linear selection and strong nonlinear ( convex) selection. Associating the eigenstructure of G with vectors of linear and nonlinear selection may provide a way of determining what long-term changes in G may be generated by the processes of natural and sexual selection.
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Study objectives: Respiratory muscle weakness and decreased endurance have been demonstrated following mechanical ventilation. However, its relationship to the duration of mechanical ventilation is not known. The aim of this study was to assess respiratory muscle endurance and its relationship to the duration of mechanical ventilation. Design: Prospective study. Setting: Tertiary teaching hospital ICU. Patients: Twenty subjects were recruited for the study who had received mechanical ventilation for a 48 h and had been discharged from the ICU. Measurements: FEV1 FVC, and maximal inspiratory pressure (Pimax) at functional residual capacity were recorded. The Pimax attained following resisted inspiration at 30% of the initial Pimax for 2 min was recorded, and the fatigue resistance index (FRI) [Pimax final/Pimax initial] was calculated. The duration of ICU length of stay (ICULOS), duration of mechanical ventilation (MVD), duration of weaning (WD), and Charlson comorbidities score (CCS) were also recorded. Relationships between fatigue and other parameters were analyzed using the Spearman correlations (p). Results: Subjects were admitted to the ICU for a mean duration of 7.7 days (SD, 3.7 days) and required mechanical ventilation for a mean duration of 4.6 days (SD, 2.5 days). The mean FRI was 0.88 (SD, 0.13), indicating a 12% fall in Pimax, and was negatively correlated with MVD (r = -0.65; p = 0.007). No correlations were found between the FRI and FEV1, FVC, ICULOS, WD, or CCS. Conclusions: Patients who had received mechanical ventilation for > 48 h have reduced inspiratory muscle endurance that worsens with the duration of mechanical ventilation and is present following successful weaning. These data suggest that patients needing prolonged mechanical ventilation are at risk of respiratory muscle fatigue and may benefit from respiratory muscle training.
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The genetic analysis of mate choice is fraught with difficulties. Males produce complex signals and displays that can consist of a combination of acoustic, visual, chemical and behavioural phenotypes. Furthermore, female preferences for these male traits are notoriously difficult to quantify. During mate choice, genes not only affect the phenotypes of the individual they are in, but can influence the expression of traits in other individuals. How can genetic analyses be conducted to encompass this complexity? Tighter integration of classical quantitative genetic approaches with modern genomic technologies promises to advance our understanding of the complex genetic basis of mate choice.
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The net effect of sexual selection on nonsexual fitness is controversial. On one side, elaborate display traits and preferences for them can be costly, reducing the nonsexual fitness of individuals possessing them, as well as their offspring, In contrast, sexual selection may reinforce nonsexual fitness if an individual's attractiveness and quality are genetically correlated. According to recent models, such good-genes mate choice should increase both the extent and rate of adaptation. We evolved 12 replicate populations of Drosophila serrata in a powerful two-way factorial experimental design to test the separate and combined contributions of natural and sexual selection to adaptation to a novel larval food resource. Populations evolving in the presence of natural selection had significantly higher mean nonsexual fitness when measured over three generations (13-15) during the course of experimental evolution (16-23% increase). The effect of natural selection was even more substantial when measured in a standardized, monogamous mating environment at the end of the experiment (generation 16; 52% increase). In contrast, and despite strong sexual selection on display traits, there was no evidence from any of the four replicate fitness measures that sexual selection promoted adaptation. In addition, a comparison of fitness measures conducted under different mating environments demonstrated a significant direct cost of sexual selection to females, likely arising from some form of male-induced harm. Indirect benefits of sexual selection in promoting adaptation to this novel resource environment therefore appear to be absent in this species, despite prior evidence suggesting the operation of good-genes mate choice in their ancestral environment. How novel environments affect the operation of good-genes mate choice is a fundamental question for future sexual selection research.
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Bu çalismada, Türkiye’deki e-bankacilik uygulamalarinda benimsenen e-atmosferik yaklasimlari stratejik deneyimsel modüller teorisi kapsaminda incelenmistir. Deneyimsel pazarlamanin, e-bankacilik sektöründe yüksek aktif kullanici sayilarina ulasilmasi ve Pazar aktörlerinin farklilastirilmasi açisindan önemi tartisilmistir. Kesif analizi, Türk e-bankacilik sektörünün iki lider aktörü olan Garanti Bank ve Akbank üzerine odaklanmistir. lk olarak, ilgili yazinin özeti ile beraber güncel uygulamalardan örnekler sunulmustur. Daha sonra tüketicilerin, algilama, hissetme, düsünme, eyleme geçme ve alakalandirma baslikli bes deneyimsel modül üzerindeki deneyimlerini degerlendirmek için ölçek gelistirilmistir. Pilot çalisma verileri üzerinde temel bilesenler analizi uygulanmistir. Sonuçlar gelismekte olan 3 gruba dikkat çekmektedir. Bunlar (1) temel deneyimsel yaklasimin faydalarini algilayanlar, (2) spesifik deneyimsel yaklasim talep edenler ve (3) bütünsel deneyimsel yaklasim talep edenlerdir. E-bankacilik sektöründe, müsterilerin yeni kültürel deneyimsel yöntemlerin gelistirilmesini bekledigi tespit edilmistir.
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Examining complete gene knockouts within a viable organism can inform on gene function. We sequenced the exomes of 3222 British Pakistani-heritage adults with high parental relatedness, discovering 1111 rare-variant homozygous genotypes with predicted loss of gene function (knockouts) in 781 genes. We observed 13.7% fewer than expected homozygous knockout genotypes, implying an average load of 1.6 recessive-lethal-equivalent LOF variants per adult. Linking genetic data to lifelong health records, knockouts were not associated with clinical consultation or prescription rate. In this dataset we identified a healthy PRDM9 knockout mother, and performed phased genome sequencing on her, her child and controls, which showed meiotic recombination sites localized away from PRDM9-dependent hotspots. Thus, natural LOF variants inform upon essential genetic loci, and demonstrate PRDM9 redundancy in humans.
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A minőségügy egyik kulcsfeladata, hogy azonosítsa az értékteremtés szempontjából kritikus tényezőket, meghatározza ezek értékét, valamint intézkedjen negatív hatásuk megelőzése és csökkentése érdekében. Az értékteremtés sok esetben folyamatokon keresztül történik, amelyek tevékenységekből, elvégzendő feladatokból állnak. Ezekhez megfelelő munkatársak kellenek, akiknek az egyik legfontosabb jellemzője az általuk birtokolt tudás. Mindezek alapján a feladat-tudás-erőforrás kapcsolatrendszer ismerete és kezelése minőségügyi feladat is. A komplex rendszerek elemzésével foglalkozó hálózatkutatás eszközt biztosíthat ehhez, ezért indokolt a minőségügyi területen történő alkalmazhatóságának vizsgálata. Az alkalmazási lehetőségek rendszerezése érdekében a szerzők kategorizálták a minőségügyi hálózatokat az élek (kapcsolatok) és a csúcsok (hálózati pontok) típusai alapján. Ezt követően definiálták a multimodális (több különböző csúcstípusból álló) tudáshálózatot, amely a feladatokból, az erőforrásokból, a tudáselemekből és a közöttük lévő kapcsolatokból épül fel. A hálózat segítségével kategóriákba sorolták a tudáselemeket, valamint a fokszámok alapján meghatározták értéküket. A multimodális hálózatból képzett tudáselem-hálózatban megadták az összefüggő csoportok jelentését, majd megfogalmaztak egy összefüggést a tudáselem-elvesztés kockázatának meghatározására. _______ The aims of quality management are to identify those factors that have significant influence on value production, qualify or quantify them, and make preventive and corrective actions in order to reduce their negative effects. The core elements of value production are processes and tasks, along with workforce having the necessary knowledge to work. For that reason the task-resource-knowledge structure is pertinent to quality management. Network science provides methods to analyze complex systems; therefore it seems reasonable to study the use of tools of network analysis in association with quality management issues. First of all the authors categorized quality networks according to the types of nodes (vertices) and links (edges or arcs). Focusing on knowledge management, they defined the multimodal knowledge network, consisting of tasks, resources, knowledge items and their interconnections. Based on their degree, network nodes can be categorized and their value can be quantified. Derived from the multimodal network knowledge-item network is to be created, where the meaning of cohesive subgroups is defined. Eventually they proposed a formula for determining the risk of knowledge loss.
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The South American electric knifefish, Brachyhypopomus gauderio, uses weakly electric fields to see and communicate in the dark. Only one study to date has investigated natural behavior in this species during the breeding season; this study proposed that B. guarerio has an exploded lek polygyny breeding system. To test this hypothesis, artificial marshes simulating the native vegetation, temperature, and water conductivities of the South American subtropics were created to study seasonal variation in associative behavior of B. gauderio during the breeding and non-breeding seasons. Mark/recapture methods were used to keep track of individual fish and their dispersion inside the experimental designs. The experimental design proved to be extremely successful at eliciting reproduction. Differences were found in seasonal variations of social behaviors between adult and juvenile populations. Although no apparent sex. differences in movement patterns were found during the breeding season; a trend for male-male aversion was found, suggesting male-male avoidance as a possible strategy guiding aspects of social behaviors in this species. Further, movement may be a tactic for mate seeking as the individuals who moved the most during the breeding season obtained the most opposite sex interactions. These findings support the exploded lek polygyny model. Social interactions are subject to complex regulation by social, physiologic and ecological factors; the extent to which these associations are repeatable may provide novel insights on the evolution of sociality as it has been shaped by natural selection.