Expansion program at St. Louis area : project no. 224-5066A : project history and completion report /

"October 1960 [OTI Issuance Date]."

Direct support and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools lists) : truck, lift, fork, GED; solid rubber tired wheels, 4000 lb capacity, 180 in lift, Army model MHE 209, NSN 3930-00-459-5948, Allis-Chalmers model F40-24PS and 100 in lift, Army model MHE 224, NSN 3930-00-165-4102, Allis-Chalmers model F40-24PS100.

Includes index.

Organizational, direct support, and general support maintenance repair parts and special tools list (including depot maintenance repair parts and special tools) for radio teletypewriter set AN/VSC-3, (NSN 5815-00-224-8130).

Includes index.

Operator's, organizational, direct support, and general support maintenance manual : radio teletypewriter set AN/VSC-2 (NSN 5815-00-224-8129).

"February 1967."

Equipment serviceability criteria for Rawin sets AN/GMD-1A (6660-224-6137) and AN/GMD-1B (6660-599-8252).

"10 August 1973."

Organizational maintenance repair parts and special tools lists for rawin sets AN/GMD-1A (NSN 6660-00-224-6137) and AN/GMD-1B (NSN 6660-00-599-8252).

Includes index.

Investigation of alleged wire tapping. Hearings before a subcommittee of the Committee on interstate commerce, United States Senate, Seventy-sixth Congress, third session, pursuant to S. Res. 224

Mode of access: Internet.

Neutralisation Of The Pharmacological Activities Of Bothrops Alternatus Venom By Anti-pla2 Iggs.

Basic phospholipases A2 (PLA2) are toxic and induce a wide spectrum of pharmacological effects, although the acidic enzyme types are not lethal or cause low lethality. Therefore, it is challenging to elucidate the mechanism of action of acidic phospholipases. This study used the acidic non-toxic Ba SpII RP4 PLA2 from Bothrops alternatus as an antigen to develop anti-PLA2 IgG antibodies in rabbits and used in vivo assays to examine the changes in crude venom when pre-incubated with these antibodies. Using Ouchterlony and western blot analyses on B. alternatus venom, we examined the specificity and sensitivity of phospholipase A2 recognition by the specific antibodies (anti-PLA2 IgG). Neutralisation assays using a non-toxic PLA2 antigen revealed unexpected results. The (indirect) haemolytic activity of whole venom was completely inhibited, and all catalytically active phospholipases A2 were blocked. Myotoxicity and lethality were reduced when the crude venom was pre-incubated with anti-PLA2 immunoglobulins. CK levels in the skeletal muscle were significantly reduced at 6 h, and the muscular damage was more significant at this time-point compared to 3 and 12 h. When four times the LD50 was used (224 μg), half the animals treated with the venom-anti PLA2 IgG mixture survived after 48 h. All assays performed with the specific antibodies revealed that Ba SpII RP4 PLA2 had a synergistic effect on whole-venom toxicity. IgG antibodies against the venom of the Argentinean species B. alternatus represent a valuable tool for elucidation of the roles of acidic PLA2 that appear to have purely digestive roles and for further studies on immunotherapy and snake envenoming in affected areas in Argentina and Brazil.

Nat2, Xrcc1 And Hogg1 Polymorphisms, Cigarette Smoking, Alcohol Consumption And Risk Of Upper Aerodigestive Tract Cancer.

To evaluate associations between polymorphisms of the N-acetyltransferase 2 (NAT2), human 8-oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing protein 1 (XRCC1) genes and risk of upper aerodigestive tract (UADT) cancer. A case-control study involving 117 cases and 224 controls was undertaken. The NAT2 gene polymorphisms were genotyped by automated sequencing and XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms were determined by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR-RFLP) methods. Slow metabolization phenotype was significantly associated as a risk factor for the development of UADT cancer (p=0.038). Furthermore, haplotype of slow metabolization was also associated with UADT cancer (p=0.014). The hOGG1 Ser326Cys polymorphism (CG or GG vs. CC genotypes) was shown as a protective factor against UADT cancer in moderate smokers (p=0.031). The XRCC1 Arg399Gln polymorphism (GA or AA vs. GG genotypes), in turn, was a protective factor against UADT cancer only among never-drinkers (p=0.048). Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population.