A high-resolution radiation hybrid map of the river buffalo major histocompatibility complex and comparison with BoLA

The major histocompatibility complex (MHC) in mammals codes for antigen-presenting proteins. For this reason, the MHC is of great importance for immune function and animal health. Previous studies revealed this gene-dense and polymorphic region in river buffalo to be on the short arm of chromosome 2, which is homologous to cattle chromosome 23. Using cattle-derived STS markers and a river buffalo radiation hybrid (RH) panel (BBURH5000), we generated a high-resolution RH map of the river buffalo MHC region. The buffalo MHC RH map (cR5000) was aligned with the cattle MHC RH map (cR 12000) to compare gene order. The buffalo MHC had similar organization to the cattle MHC, with class II genes distributed in two segments, class IIa and class IIb. Class IIa was closely associated with the class I and class III regions, and class IIb was a separate cluster. A total of 53 markers were distributed into two linkage groups based on a two-point LOD score threshold of ≥8. The first linkage group included 32 markers from class IIa, class I and class III. The second linkage group included 21 markers from class IIb. Bacterial artificial chromosome clones for seven loci were mapped by fluorescence in situ hybridization on metaphase chromosomes using single- and double-color hybridizations. The order of cytogenetically mapped markers in the region corroborated the physical order of markers obtained from the RH map and served as anchor points to align and orient the linkage groups. © 2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics.

Aplicação do eletrocapilaridade na manipulação de microgotas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Teoria quântica do campo escalar real com autoacoplamento quártico - simulações de Monte Carlo na rede com um algoritmo worm

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Funções de Green para problemas de valor de contorno com três pontos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito do tratamento a plasma do politetrafluoroetileno (PTFE) nas suas propriedades eletrostáticas e superficiais

Pós-graduação em Ciência e Tecnologia de Materiais - FC

Análise molecular de pacientes com síndromes de Smith-Magenis

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

3D raytracing through homogeneous anisotropic media with smooth interfaces

O raio conectando dois pontos em um meio anisotrópico, homogêneo por partes e com variação lateral, é calculado utilizando-se técnicas de continuação em 3D. Se combinado com algoritmos para solução do problema de valor inicial, o método pode ser estendido para o cálculo de eventos qS₁ e qS₂. O algoritmo apresenta a mesma eficiência e robustez que implementações de técnicas de continuação em meios isotrópicos. Rotinas baseadas neste algoritmo têm várias aplicações de interesse. Primeiramente, na modelagem e inversão de parâmetros elásticos na presença de anisotropia. Em segundo lugar, as iterações de Newton-Raphson produzem atributos da frente de onda como vetor vagarosidade e a matrix hessiana do tempo de trânsito, quantidades que permitem determinar o espalhamento geométrico e aproximações de segunda ordem para o tempo de trânsito. Estes atributos permitem calcular as amplitudes ao longo do raio e investigar os efeitos da anisotropia no empilhamento CRS em modelos de velocidade simples.

Kallen-Lehmann representation of noncommutative quantum electrodynamics

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A real-time thermal field theoretical analysis of Kubo-type shear viscosity: Numerical understanding with simple examples

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nucleon thermal width owing to pion-baryon loops and its contributions to shear viscosity

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Teorias de Spin-1: decomposição em helicidades, redução dimensional e imersão de calibre

We have studied the physical content of the following models: Maxwell, Proca, Self-Dual and Maxwell-Chern-Simons. One method we have used is the decomposition in the so called helicity variables, which can be done in the Lagrangian formalism. It leads to the correct counting of degrees of freedom without choosing a gauge condition. The method separates the propagating modes from the non-propagating ones. The Hamiltonian of the MCS and the AD is calculated. The second method used here is the analysis of the sign of the imaginary part of the residues of the two-point amplitude of the theory, showing that the models analyzed are free of ghosts. We also carry the dimensional reduction of the Maxwell-Chern-Simons and Self-Dual models from D = 2+1 to D = 1 + 1 dimensions. Next, we show that the dimensional reduction of those equivalent models also leads to equivalent models in D=1+1. Even more interesting is the fact, demonstrated here, that those reduced models can also be connected via gauge embedding. So the gauge embedding of the Self-Dual model into the Maxwell-Chern-Simons theory is preserved by the dimensional reduction

Rhodium-Catalyzed Hydroboration: Directed Asymmetric Desymmetrization

Rhodium-catalyzed asymmetric hydroboration in conjunction with directing groups can be used control relative and absolute stereochemistry. Hydroboration has the potential to create new C–C, C–O, and C–N bonds from an intermediate C–B bond with retention of stereochemistry. Desymmetrization resulting in the loss of one or more symmetry elements can give rise to molecular chirality, i.e., the conversion of a prochiral molecule to one that is chiral. Unsaturated amides and esters hold the potential for two-point binding to the rhodium catalyst and have been shown to direct the regiochemistry and impact stereochemistry in asymmetric hydroborations of acyclic β,γ-unsaturated substrates. In the present study, the pendant amide functionality directs the hydroboration cis in the cyclic substrates studied; the corresponding ester substrates do so to a lesser extent. The enantioselectivity is determined by regioselective addition to the re or si site of the rhodium-complexed alkene. The effect of catalyst, ligand and borane on the observed diastereoselectivity and enantioselectivity for a variety of cyclopentenyl ester and amide substrates is discussed.

Analytic perturbation theory for bound states in the transfer matrix spectrum of weakly correlated lattice ferromagnetic spin systems

We consider general d-dimensional lattice ferromagnetic spin systems with nearest neighbor interactions in the high temperature region ('beta' << 1). Each model is characterized by a single site apriori spin distribution taken to be even. We also take the parameter 'alfa' = ('S POT.4') - 3 '(S POT.2') POT.2' > 0, i.e. in the region which we call Gaussian subjugation, where ('S POT.K') denotes the kth moment of the apriori distribution. Associated with the model is a lattice quantum field theory known to contain a particle of asymptotic mass -ln 'beta' and a bound state below the two-particle threshold. We develop a 'beta' analytic perturbation theory for the binding energy of this bound state. As a key ingredient in obtaining our result we show that the Fourier transform of the two-point function is a meromorphic function, with a simple pole, in a suitable complex spectral parameter and the coefficients of its Laurent expansion are analytic in 'beta'.

Effectiveness of low-level laser therapy for patients with carpal tunnel syndrome: design of a randomized single-blinded controlled trial

Background: Carpal tunnel syndrome is the most common neuropathy in the upper extremity, resulting from the compression of the median nerve at wrist level. Clinical studies are essentials to present evidence on therapeutic resources use at early restoration on peripheral nerve functionality. Low-level laser therapy has been widely investigated in researches related to nerve regeneration. Therefore, it is suggested that the effect of low-level laser therapy associated with other conservative rehabilitation techniques may positively affect symptoms and overall hand function in compressive neuropathies such as carpal tunnel syndrome. The aim of this study is to evaluate the effectiveness of low-level laser therapy in addition to orthoses therapy and home orientations in patients with carpal tunnel syndrome. Methods/Design: Patients older than 18 years old will be included, with clinical diagnosis of carpal tunnel syndrome, excluding comorbidies. A physiotherapist will conduct intervention, with a blinding evaluator. Randomization will be applied to allocate the patients in each group: with association or not to low-level laser therapy. All of them will be submitted to orthoses therapy and home orientations. Outcome will be assessed through: pain visual analogic scale, Semmes Weinstein monofilaments (TM) threshold sensibility test, Pinch Gauge T, Boston Carpal Tunnel Questionnaire and two point discrimination test. Discussion: This paper describes the design of a randomized controlled trial, which aim to assess the effectiveness of conservative treatment added to low-level laser therapy for patients with carpal tunnel syndrome. Trial registration: Brazilian Clinical Trials Registry (ReBec) - 75ddtf / Universal Trial Number: U1111-1121-5184

Ein, zwei Punkte zu Nichtkommutativer Geometrie und Quantenfeldtheorie auf diskreten Räumen

Über viele Jahre hinweg wurden wieder und wieder Argumente angeführt, die diskreten Räumen gegenüber kontinuierlichen Räumen eine fundamentalere Rolle zusprechen. Unser Zugangzur diskreten Welt wird durch neuere Überlegungen der Nichtkommutativen Geometrie (NKG) bestimmt. Seit ca. 15Jahren gibt es Anstrengungen und auch Fortschritte, Physikmit Hilfe von Nichtkommutativer Geometrie besser zuverstehen. Nur eine von vielen Möglichkeiten ist dieReformulierung des Standardmodells derElementarteilchenphysik. Unter anderem gelingt es, auch denHiggs-Mechanismus geometrisch zu beschreiben. Das Higgs-Feld wird in der NKG in Form eines Zusammenhangs auf einer zweielementigen Menge beschrieben. In der Arbeit werden verschiedene Ziele erreicht:Quantisierung einer nulldimensionalen ,,Raum-Zeit'', konsistente Diskretisierungf'ur Modelle im nichtkommutativen Rahmen.Yang-Mills-Theorien auf einem Punkt mit deformiertemHiggs-Potenzial. Erweiterung auf eine ,,echte''Zwei-Punkte-Raum-Zeit, Abzählen von Feynman-Graphen in einer nulldimensionalen Theorie, Feynman-Regeln. Eine besondere Rolle werden Termini, die in derQuantenfeldtheorie ihren Ursprung haben, gewidmet. In diesemRahmen werden Begriffe frei von Komplikationen diskutiert,die durch etwaige Divergenzen oder Schwierigkeitentechnischer Natur verursacht werden könnten.Eichfixierungen, Geistbeiträge, Slavnov-Taylor-Identität undRenormierung. Iteratives Lösungsverfahren derDyson-Schwinger-Gleichung mit Computeralgebra-Unterstützung,die Renormierungsprozedur berücksichtigt.