Expressionist painter Emil Luethy seated at an outdoor dining table Portraits Men

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Writer Clara Michelson (second from left) seated at an outdoor table with three unidentified women and one unidentified man; Saint-Brevin-les-Pins, France Portraits Groups

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Seated portrait of Adele Rosenzweig at table with book Portraits; Women

Stamp on verso reads "Salokipie A608 _ Kassel"

Portrait of Paula Pohl Rieser nee Wagner seated at an outdoor table Portraits Women

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Dr. Bernhard Bardach at dining table with unidentified officers Military; Portraits

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Louis Salomonsohn with unidentified man at table; Rome Portraits; Groups; Men

Dedicated by Emano Loevinson to his Father

Passover table with candlesticks, wine goblet and matzoh; Juedische Winterhilfe der Juedische Gemeinde Jewish Institutions

"50000 Mazzoth wurden zu Pessach ausgegeben. ca. 1000 Personen wurde die Teilnahmean den Sederabenden ermoeglicht."

Leo Baeck sitting at table speaking with Congressman Adolph Sabath; Chicago Portraits; Groups; Men

Page 61 of the "American Jewish Cavalcade" scrapbook of Leo Baeck in New York found in ROS 10 Folder 3

Map of water table depths of theKenigezkiǐ fond

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Map of water table depths of the Semi-Kolodez︠ia︡nskiǐ fond

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Cross Talk between Receptor Guanylyl Cyclase C and c-src Tyrosine Kinase Regulates Colon Cancer Cell Cytostasis

Increased activation of c-src seen in colorectal cancer is an indicator of a poor clinical prognosis, suggesting that identification of downstream effectors of c-src may lead to new avenues of therapy. Guanylyl cyclase C (GC-C) is a receptor for the gastrointestinal hormones guanylin and uroguanylin and the bacterial heat-stable enterotoxin. Though activation of GC-C by its ligands elevates intracellular cyclic GMP (cGMP) levels and inhibits cell proliferation, its persistent expression in colorectal carcinomas and occult metastases makes it a marker for malignancy. We show here that GC-C is a substrate for inhibitory phosphorylation by c-src, resulting in reduced ligand-mediated cGMP production. Consequently, active c-src in colonic cells can overcome GC-C-mediated control of the cell cycle. Furthermore, docking of the c-src SH2 domain to phosphorylated GC-C results in colocalization and further activation of c-src. We therefore propose a novel feed-forward mechanism of activation of c-src that is induced by cross talk between a receptor GC and a tyrosine kinase. Our findings have important implications in understanding the molecular mechanisms involved in the progression and treatment of colorectal cancer.

What people talk about when they talk about quitting

As part of an ongoing project to explore the design of behaviour-change technology for smoking cessation, we analysed a successful community who come together on the popular Reddit website to discuss quitting and to encourage each other's quit attempts. We found that users remain anonymous but identify according to their quit stage. We examined the form and content of posts, finding that narratives about people and events are more common than other rhetorical forms. Many speak of ongoing struggles with quit attempts. Our analysis reveals forms of sociality spontaneously enacted in a self-managed community of quitters. We compare our results with earlier work on social media and behaviour change.

Consumer’s comparison between local and imported organic products: A hedonic analysis of the Japanese table wine market

Although hundreds of thousands of organic products are traded on a daily basis, it is less known how imported organic products are evaluated by consumers in an importing country. The paper analyzes Japanese wine point of sale (POS) data to examine whether consumers differentiate between local and imported organic products. The results of our hedonic analyses show that the premium for imported organic red (white) wines is about 42.996 % (8.872 %) while that for domestic red (white) organic wines is about 6.440 % (1.214 %), implying that Japanese consumers pay higher premiums for imported organic agricultural products than for those produced in Japan.