'Bio-nano interactions: new tools, insights and impacts': summary of the Royal Society discussion meeting

Bio-nano interactions can be defined as the study of interactions between nanoscale entities and biological systems such as, but not limited to, peptides, proteins, lipids, DNA and other biomolecules, cells and cellular receptors and organisms including humans. Studying bio-nano interactions is particularly useful for understanding engineered materials that have at least one dimension in the nanoscale. Such materials may consist of discrete particles or nanostructured surfaces. Much of biology functions at the nanoscale; therefore, our ability to manipulate materials such that they are taken up at the nanoscale, and engage biological machinery in a designed and purposeful manner, opens new vistas for more efficient diagnostics, therapeutics (treatments) and tissue regeneration, so-called nanomedicine. Additionally, this ability of nanomaterials to interact with and be taken up by cells allows nanomaterials to be used as probes and tools to advance our understanding of cellular functioning. Yet, as a new technology, assessment of the safety of nanomaterials, and the applicability of existing regulatory frameworks for nanomaterials must be investigated in parallel with development of novel applications. The Royal Society meeting 'Bio-nano interactions: new tools, insights and impacts' provided an important platform for open dialogue on the current state of knowledge on these issues, bringing together scientists, industry, regulatory and legal experts to concretize existing discourse in science law and policy. This paper summarizes these discussions and the insights that emerged.

A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI

In an effort to unify the nomenclature of Trypanosoma cruzi, the causative agent of Chagas disease, an updated system was agreed upon at the Second Satellite Meeting. A consensus was reached that T. cruzi strains should be referred to by six discrete typing units (T. cruzi I-VI). The goal of a unified nomenclature is to improve communication within the scientific community involved in T. cruzi research. The justification and implications will be presented in a subsequent detailed report.

Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.

In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have long been pursuing. Thirty years ago, when molecular pharmacogenomics evolved, we anticipated that these genetic biomarkers would soon obviate the routine use of drug therapies in a way that patients should adapt to the therapy rather than the opposite. This expected revolution in routine clinical practice never took place as quickly nor with the intensity as initially expected. The concerted action of operating multicenter networks holds great promise for future studies to identify biomarkers related to drug toxicity and to provide better insight into the underlying pathogenesis. Today some pharmacogenomic advances are already widely accepted, but pharmacogenomics still needs further development to elaborate more precise algorithms and many barriers to implementing individualized medicine exist. We briefly discuss our view about these barriers and we provide suggestions and areas of focus to advance in the field.

Verbrachen, belge [coureur cycliste participant au meeting de la Toussaint, 1er novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56708

[Gerardus Petrus dit Gerard] Leene [coureur cycliste néerlandais participant au meeting de la Toussaint, 1er novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56715

[Piet] Moeskops [coureur cycliste néerlandais participant au meeting de la Toussaint, 1er novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56698

[Pierre] Sergent [coureur cycliste participant au meeting de la Toussaint, 2 novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56714

[Pierre] Sergent [coureur cycliste participant au meeting de la Toussaint, 2 novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56713

[René] Chassot [coureur cycliste participant au meeting de la Toussaint, 1er novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56709

[Gerardus Petrus, dit Gerard] Leene [coureur cycliste néerlandais participant au meeting de la Toussaint, 1er novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56700

[Piet] Moeskops [coureur cycliste néerlandais participant au meeting de la Toussaint, 1er novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56699