La educación en las revistas : 1959, 1a quincena marzo.

Analiza y comenta una selección de artículos publicados en los diarios 'Hoy' (Badajoz), 'El Diario Palentino', 'El Alcázar', 'Libertad' (Valladolid), 'Ya', 'Diario Regional' (Valladolid), y en las revistas Servicio' (Madrid), 'Educadores', 'El Magisterio Español', 'Escuela Española', 'El Mundo Escolar', 'El Español', 'Signo' sobre los problemas de educación más actuales. Agrupa las colaboraciones en las secciones: Enseñanza Primaria; Extensión cultural, Enseñanza Universitaria, Bellas Artes. Transcribe, a pié de página, el nombre del autor, el título y los datos para la localización del artículo.

La educación en las revistas : 1959, 1a quincena mayo.

Analiza y comenta una selección de artículos publicados en el diario 'Arriba' y en las revistas Servicio' (Madrid), 'El Maestro', 'El Magisterio Español', 'Mundo Escolar', 'Boletín de Educación' (Pamplona), 'Gaceta del Sordomudo' (Madrid), 'Enseñanza Media', 'Santa Cruz' (Valladolid) sobre los problemas de educación más actuales. Agrupa las colaboraciones en las secciones Enseñanza Primaria; Educación Especial; Enseñanza Media; Enseñanza Universitaria. Transcribe, a pié de página, el nombre del autor, el título y los datos para la localización del artículo.

La educación en las revistas : 1959, 1a quincena junio.

Analiza y comenta una selección de artículos publicados en los diarios 'El Correo Español', 'Arriba', en las revistas 'Mundo Escolar', 'Boletín de Educación' (Pamplona), 'Escuela Española', 'Servicio' (Madrid), 'Enseñanza Media', 'Hojas Informativas', 'Técnica Económica' (Madrid), sobre los problemas de educación más actuales. Agrupa las colaboraciones en las secciones: Enseñanza Primaria; Enseñanza Media; Enseñanza Laboral y Enseñanzas Técnicas; Enseñanza Universitaria. Transcribe, a pié de página, el nombre del autor, el título y los datos para la localización del artículo.

La educación en las revistas : 1959, 1a quincena octubre.

Analiza y comenta una selección de artículos publicados en el diario' Arriba', y en las revistas 'Vida Escolar', 'Educadores', 'Revista Española de Pedagogía', 'Molino de Papel' (Madrid), 'Enseñanza Media', 'Técnica Económica', sobre los problemas de educación más actuales. Agrupa las colaboraciones en las secciones: Enseñanza Primaria; Enseñanza Media; Enseñanzas Técnicas; Enseñanza Universitaria. Transcribe, a pié de página, el nombre del autor, el título y los datos para la localización del artículo.

La educación en las revistas : 1959, 1a quincena noviembre.

Analiza y comenta una selección de artículos publicados en el diario 'Arriba', y en las revistas 'Revista Calasancia', 'Perspectivas Pedagógicas', 'Vida Escolar', 'Pro Infancia y Juventud' sobre los problemas de educación más actuales. Agrupa las colaboraciones en las secciones: Cuestiones generales de enseñanza; Enseñanza Primaria; Enseñanza Media; Enseñanza Universitaria. Transcribe, a pié de página, el nombre del autor, el título y los datos para la localización del artículo.

La educación en las revistas : 1959, 1a quincena diciembre.

Analiza y comenta una selección de artículos publicados en las revistas 'Escuela Española', 'Incunable' (Salamanca), 'Vida Escolar', 'Revista Española de Pedagogía', 'Familia Española', '24' (CEU. Madrid) sobre los problemas de educación más actuales. Agrupa las colaboraciones en las secciones: Cuestiones generales de enseñanza; Enseñanza Primaria; Enseñanza Media; Enseñanza Universitaria. Transcribe, a pié de página, el nombre del autor, el título y los datos para la localización del artículo.

Analytical potentials for triatomic molecules VIII. A two valued surface for the lowest 1A¢ surfaces of H2O

Ab initio calculations of the energy have been made at approximately 150 points on the two lowest singlet A' potential energy surfaces of the water molecule, 1A' and 1A', covering structures having D∞h, C∞v, C2v and Cs symmetries. The object was to obtain an ab initio surface of uniform accuracy over the whole three-dimensional coordinate space. Molecular orbitals were constructed from a double zeta plus Rydberg basis, and correlation was introduced by single and double excitations from multiconfiguration states which gave the correct dissociation behaviour. A two-valued analytical potential function has been constructed to fit these ab initio energy calculations. The adiabatic energies are given in our analytical function as the eigenvalues of a 2 2 matrix, whose diagonal elements define two diabatic surfaces. The off-diagonal element goes to zero for those configurations corresponding to surface intersections, so that our adiabatic surface exhibits the correct Σ/II conical intersections for linear configurations, and singlet/triplet intersections of the O + H2 dissociation fragments. The agreement between our analytical surface and experiment has been improved by using empirical diatomic potential curves in place of those derived from ab initio calculations.

Progressive palaeoenvironmental change during the Late Barremian-Early Aptian as prelude to Oceanic Anoxic Event 1a: Evidence from the Gorgo a Cerbara section (Umbria-Marche basin, central Italy)

During Oceanic Anoxic Event 1a (OAE 1a, 120 Ma; Li et al., 2008), organic carbon-rich layers were deposited in marine environments under anoxic conditions on a global scale. In this study, palaeoenvironmental conditions leading to this event are characterised by studying the Upper Barremian to the Lower Aptian succession of the Gorgo a Cerbara section (central Italy). For this, an integrated multi-proxy approach (δ13Ccarb; δ13Corg; δ18O; phosphorus; Total Organic Carbon, TOC; bulk-rock mineralogy, as well as redox-sensitive trace elements — RSTEs) has been applied. During the LateBarremian, thin organic-rich layers occur episodically, and associated Corg:Ptot ratios indicate the presence of intermittent dysoxic to anoxic conditions. Coarse correlations are observed between TOC, P and biogenic silica contents, indicating links between P availability, productivity, and TOC preservation. However, the corresponding δ13Ccarb and δ18O records remain quite stable, indicating that these brief periods of enhanced TOC preservation did not have sufficient impact on the marine carbon reservoir to deviate δ13C records. Around the Barremian–Aptian boundary, TOC-enriched layers become more frequent. These layers correlate with negative excursions in the δ13Ccarb and δ13Corg records, possibly due to a warming period as indicated by the δ18O record. During the earliest Aptian, this warming trend is reverted into a cooling trend, which is then followed by an important warming step near the onset of Oceanic Anoxic Event 1a (OAE 1a). During this time period, organic-rich intervals occur, which are characterised by the progressive increase in RSTE. The warming step prior the onset of OAE 1a is associated with the well-known negative spike in δ13Ccarb and δ13Corg records, an important peak in P accumulation, RSTE enrichments and Corg:Ptot ratios indicating the prevalence of anoxic conditions. The Selli Level itself may document a cooling phase. RSTE enrichments and Corg:Ptot ratios confirm the importance of anoxic conditions during OAE 1a at this site. The Gorgo a Cerbara section is interpreted to reflect the progressive impact of palaeoenvironmental change related to the formation of the Ontong-Java plate-basalt plateau, which started already around the Barremian–Aptian boundary and culminated into OAE 1a.

Effects of the 5-HT(1A) agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on cocaine choice in cynomolgus monkeys

Drugs that alter brain serotonin (5-HT) function can modulate the behavioral effects of cocaine, but the underlying receptor mechanisms are poorly understood. The present study examined the effects of the selective 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 0.01-0.1 mg/kg, i.v.) on cocaine self-administration in the context of a choice procedure. Five adult male cynomolgus monkeys self-administered cocaine (saline, 0.003-0.03 mg/kg per injection) under a concurrent fixed-ratio 50 schedule of food (1-g banana-flavored pellets) and cocaine presentation. Allocation of responses to the cocaine-associated lever (cocaine choice) increased in a dose-related manner from < or =20% of total responses when saline or 0.003 mg/kg per injection cocaine was the alternative to food to > or =75% when 0.03 mg/kg per injection cocaine was available. In four of five monkeys, when choice was between a low cocaine dose and food, 0.01 mg/kg 8-OH-DPAT increased injection-lever responding. At cocaine doses which occasioned > or =75% cocaine choice, 8-OH-DPAT did not alter response allocation. In the fifth monkey, 8-OH-DPAT only decreased injection-lever responding. When choice was between saline and food, 8-OH-DPAT did not reliably shift responding to the injection lever, except at doses that disrupted operant performance. These results suggest that a 5-HT1A receptor agonist can increase the reinforcing strength of a low cocaine dose relative to a concurrently available non-drug reinforcer.

Two-dimensional QSAR studies on arylpiperazines as high-affinity 5-HT(1A) receptor ligands

5-HT(1A) receptor plays an important role in the delayed onset of antidepressant action of a class of selective serotonin reuptake inhibitors. Moreover, 5-HT(1A) receptor levels have been shown to be altered in patients suffering from major depression. In this work, hologram quantitative structure-activity relationship (HQSAR) studies were performed on a series of arylpiperazine compounds presenting affinity to the 5-HT(1A) receptor. The models were constructed with a training set of 70 compounds. The most significant HQSAR model (q(2) = 0.81, r(2) = 0.96) was generated using atoms, bonds, connections, chirality, and donor and acceptor as fragment distinction, with fragment size of 6-9. Predictions for an external test set containing 20 compounds are in good agreement with experimental results showing the robustness of the model. Additionally, useful information can be obtained from the 2D contribution maps.

Pharmacophore-based 3D QSAR studies on a series of high affinity 5-HT(1A) receptor ligands

5-HT(1A) receptor antagonists have been employed to treat depression, but the lack of structural information on this receptor hampers the design of specific and selective ligands. In this study, we have performed CoMFA studies on a training set of arylpiperazines (high affinity 5-HT(1A) receptor ligands) and to produce an effective alignment of the data set, a pharmacophore model was produced using Galahad. A statistically significant model was obtained, indicating a good internal consistency and predictive ability for untested compounds. The information gathered from our receptor-independent pharmacophore hypothesis is in good agreement with results from independent studies using different approaches. Therefore, this work provides important insights on the chemical and structural basis involved in the molecular recognition of these compounds. (C) 2010 Elsevier Masson SAS. All rights reserved.

Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery

The enzyme dihydroorotate dehydrogenase (DHODH) has been suggested as a promising target for the design of trypanocidal agents. We report here the discovery of novel inhibitors of Trypanosoma cruzi DHODH identified by a combination of virtual screening and ITC methods. Monitoring of the enzymatic reaction in the presence of selected ligands together with structural information obtained from X-ray crystallography analysis have allowed the identification and validation of a novel site of interaction (S2 site). This has provided important structural insights for the rational design of T cruzi and Leishmania major DHODH inhibitors. The most potent compound (1) in the investigated series inhibits TcDHODH enzyme with K(i)(app) value of 19.28 mu M and possesses a ligand efficiency of 0.54 kcal mol(-1) per non-H atom. The compounds described in this work are promising hits for further development. (C) 2010 Elsevier Masson SAS. All rights reserved.

Ensuring balance in corporate governance : parts 2F.1 and 2F.1A of the Corporations Law

Effective corporate governance must balance the competing, and at times conflicting, objectives of efficient endeavour and accountability. The CLERP amendments to the Corporations Law introduced on 13 March 2000 go a long way towards providing this balance. While the business judgement rule was introduced to promote efficient endeavour, Pts 2F.1 and 2F.1A maintain corporate accountability. This article compares Pts 2F.t and 2F.1A of the Corporations Law. It is argued that, although there are procedural and substantive differences between the two parts that need to be understood by practitioners, the importance of the two Parts is that they work together to provide for a much-needed improvement and enhancement of shareholder rights and remedies, thus upholding accountability in corporate governance.