IPA: Integrated predictive gene signature from gene expression based breast cancer patient samples

Background: Novel predictive markers are needed to accurately diagnose the breast cancer patients so they do not need to undergo any unnecessary aggressive therapies. Various gene expression studies based predictive gene signatureshave generated in the recent past to predict the binary estrogen-receptor subclass or to predict the therapy response subclass. However, the existing algorithms comes with many limitations, including low predictive performances over multiple cohorts of patients and non-significant or limited biological roles associated with thepredictive gene signatures. Therefore, the aim of this study is to develop novel predictive markers with improved performances.Methods: We propose a novel prediction algorithm called IPA to construct a predictive gene signature for performing multiple prediction tasks of predicting estrogen-receptor based binary subclass and predicting chemotherapy response (neoadjuvantly) based binary subclass. The constructed gene signature with considering multiple classification techniques was used to evaluate the algorithm performance on multiple cohorts of breast cancer patients.Results: The evaluation on multiple validation cohorts demonstrated that proposed algorithm achieved stable and high performance to perform prediction tasks, with consideration given to any classification techniques. We show that the predictive gene signature of our proposed algorithm reflects the mechanisms underlying the estrogen-receptors or response to therapy with significant greater biological interpretations, compared with the other existing algorithm.

Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co-evolved with this third family member, all sharing binding motifs for IL-15Rα

Interleukins 2 and 15 (IL-2 and IL-15) are highly differentiated but related cytokines with overlapping, yet also distinct functions, and established benefits for medical drug use. The present study identified a gene for an ancient third IL-2/15 family member in reptiles and mammals, interleukin 15-like (IL-15L), which hitherto was only reported in fish. IL-15L genes with intact open reading frames (ORFs) and evidence of transcription, and a recent past of purifying selection, were found for cattle, horse, sheep, pig and rabbit. In human and mouse the IL-15L ORF is incapacitated. Although deduced IL-15L proteins share only ~21 % overall amino acid identity with IL-15, they share many of the IL-15 residues important for binding to receptor chain IL-15Rα, and recombinant bovine IL-15L was shown to interact with IL-15Rα indeed. Comparison of sequence motifs indicates that capacity for binding IL-15Rα is an ancestral characteristic of the IL-2/15/15L family, in accordance with a recent study which showed that in fish both IL-2 and IL-15 can bind IL-15Rα. Evidence reveals that the species lineage leading to mammals started out with three similar cytokines IL-2, IL-15 and IL-15L, and that later in evolution (1) IL-2 and IL-2Rα receptor chain acquired a new and specific binding mode and (2) IL-15L was lost in several but not all groups of mammals. The present study forms an important step forward in understanding this potent family of cytokines, and may help to improve future strategies for their application in veterinarian and human medicine.

Estratégias de investimentos para o Brasil baseadas em finanças comportamentais

Evidências de incompatibilidades entre a dinâmica do mercado de ações e os conceitos descritos pelos modelos de racionalidade plena têm estimulado o desenvolvimento de estudos a cerca do comportamento dos agentes econômicos, como forma de entender algumas anomalias presentes no processo de formação de preço dos ativos, dando origem aos estudos na área de Finanças Comportamentais. Este trabalho refere-se ao estudo de estratégias baseadas em Finanças Comportamentais aplicadas ao mercado de ações brasileiro.

Organizational design as an enabler for innovation: evidence from a German Mechanical Engineering Company

Over the past two decades there has been a profusion of empirical studies of organizational design and its relationship to efficiency, productivity and flexibility of an organization. In parallel, there has been a wide range of studies about innovation management in different kind of industries and firms. However, with some exceptions, the organizational and innovation management bodies of literature tend to examine the issues of organizational design and innovation management individually, mainly in the context of large firms operating at the technological frontier. There seems to be a scarcity of empirical studies that bring together organizational design and innovation and examine them empirically and over time in the context of small and medium sized enterprises. This dissertation seeks to provide a small contribution in that direction. This dissertation examines the dynamic relationship between organizational design and innovation. This relationship is examined on the basis of a single-case design in a medium sized mechanical engineering company in Germany. The covered time period ranges from 1958 until 2009, although the actual focus falls on the recent past. This dissertation draws on first-hand qualitative empirical evidence gathered through extensive field work. The main findings are: 1. There is always a bundle of organizational dimensions which impacts innovation. These main organizational design dimensions are: (1) Strategy & Leadership, (2) Resources & Capabilities, (3) Structure, (4) Culture, (5) Networks & Partnerships, (6) Processes and (7) Knowledge Management. However, the importance of the different organizational design dimensions changes over time. While for example for the production of simple, standardized parts, a simple organizational design was appropriate, the company needed to have a more advanced organizational design in order to be able to produce customized, complex parts with high quality. Hence the technological maturity of a company is related to its organizational maturity. 2. The introduction of innovations of the analyzed company were highly dependent on organizational conditions which enabled their introduction. The results of the long term case study show, that some innovations would not have been introduced successfully if the organizational elements like for example training and qualification, the build of network and partnerships or the acquisition of appropriate resources and capabilities, were not in place. Hence it can be concluded, that organizational design is an enabling factor for innovation. These findings contribute to advance our understanding of the complex relationship between organizational design and innovation. This highlights the growing importance of a comprehensive, innovation stimulating organizational design of companies. The results suggest to managers that innovation is not only dependent on a single organizational factor but on the appropriate, comprehensive design of the organization. Hence manager should consider to review regularly the design of their organizations in order to maintain a innovation stimulating environment.

Inflação no Brasil e preços internacionais

No início dos anos 90, começou a ser observada uma queda e uma maior estabilização da inflação mundial, principalmente em economias desenvolvidas. Esse fenômeno também foi observado em economias em desenvolvimento como a brasileira, protagonistas de momentos de hiperinflação em um passado recente. Com a queda substancial da inflação mundial, alguns economistas sugerem que se incorporem os efeitos dos fatores globais na dinâmica da inflação doméstica. Este presente estudo tem por objetivo verificar se fatores externos têm reduzido a sensibilidade dos preços domésticos às condições econômicas exclusivamente domésticas. É feita uma análise do papel dos preços internacionais na dinâmica da taxa de inflação no Brasil através de estudos da dinâmica da curva de Phillips, a partir da metodologia VAR. Através dos resultados obtidos, concluiu-se que apesar de boa parte da estabilidade da inflação ser conseqüência da credibilidade da política monetária adotada pelo Banco Central, da maneira como ele consegue ancorar essas expectativas e da adoção de boas práticas monetárias e fiscais, não se pode negar o importante papel dos fatores globais na dinâmica da inflação brasileira.

Análise da alocação de ativos para carteiras de planos tradicionais em entidades abertas de previdência complementar

Neste trabalho discutimos a evolução recente do mercado de previdência privada complementar aberta no Brasil, e os principais fatores motivadores dessa evolução. Concentramo-nos na participação dos chamados planos tradicionais de previdência complementar, com mínimos garantidos e reversão de excedentes financeiros. Mostramos que essa modalidade de plano possui um conjunto de opções embutidas que representam direitos do participante, ou cliente, sobre o capital da seguradora ou entidade aberta de previdência complementar (EAPC). Essas opções representam riscos adicionais no balanço da EAPC que não estão necessariamente neutralizados. Para tentar neutralizar esses riscos a gestão dos ativos garantidores dos passivos dos planos tradicionais precisa levar em consideração as características desses passivos. Apresentamos cinco critérios comuns, alguns detalhadamente descritos na literatura de finanças, para escolha e alocação de carteiras de ativos em EAPCs, considerando as especificidades dos planos tradicionais e as suas opções embutidas. Testamos carteiras selecionadas com base nesses critérios para o passado recente e procuramos avaliar o impacto dos resultados na geração de receita esperada por essa modalidade de produto. Os resultados indicam que, quanto mais correlacionada for à performance da carteira de ativos com o perfil de evolução dos passivos, mais eficiente será a neutralização dos riscos representados pelas opções emitidas pela EAPC, e menos volátil será o fluxo de receita gerado por essa modalidade de produto.

Money versus memory

A well–established fact in monetary theory is that a key ingredient for the essentiality of money is its role as a form of memory. In this paper we study a notion of memory that includes information about an agent’s past actions and trading opportunities but, in contrast to Kocherlakota (1998), does not include information about the past actions and trading opportunities of an agent’s past partners. We first show that the first–best can be achieved with memory even if it only includes information about an agent’s very recent past. Thus, money can fail to be essential even if memory is minimal. We then establish, more interestingly, that if information about trading opportunities is not part of an agent’s record, then money can be better than memory. This shows that the societal benefit of money lies not only on being a record of past actions, but also on being a record of past trading opportunities, a fact that has been overlooked by the monetary literature.

Constructing coincident and leading indices of economic activity for the brazilian economy

This paper has three original contributions. The first is the reconstruction effort of the series of employment and income to allow the creation of a new coincident index for the Brazilian economic activity. The second is the construction of a coincident index of the economic activity for Brazil, and from it, (re)establish a chronology of recessions in the recent past of the Brazilian economy. The coincident index follows the methodology proposed by TCB and it covers the period 1980:1 to 2007:11. The third is the construction and evaluation of many leading indicators of economic activity for Brazil which fills an important gap in the Brazilian Business Cycles literature.

Tópicos em Econometria Aplicada

This paper has three original contributions. The first is the reconstruction of employment and income series to allow the creation of a new coincident index for the Brazilian economic activity. The second is the construction of a coincident index of the economic activity for Brazil, and from it, (re) establish a chronology of recessions in the recent past of the Brazilian economy. The coincident index follows the methodology proposed by The Conference Board and it covers the period 1980:1 to 2007:11. The third is the construction and evaluation of many leading indicators of economic activity for Brazil which fills an important gap in the Brazilian Business Cycles literature.

Constructing coincident and leading indices of economic activity for the brazilian economy

This paper has three original contributions. The first is the reconstruction effort of the series of employment and income to allow the creation of a new coincident index for the Brazilian economic activity. The second is the construction of a coincident index of the economic activity for Brazil, and from it, (re) establish a chronology of recessions in the recent past of the Brazilian economy. The coincident index follows the methodology proposed by The Conference Board (TCB) and it covers the period 1980:1 to 2007:11. The third is the construction and evaluation of many leading indicators of economic activity for Brazil which fills an important gap in the Brazilian Business Cycles literature.

Estrutura e determinantes do consumo de bens duráveis no Brasil

Este trabalho de dissertação busca averiguar como a estrutura do consumo de bens duráveis dos domicílios brasileiros evoluiu ao longo do tempo e o que determinou a mudança nesse padrão, isto é, que variáveis foram determinantes para que houvesse maior acesso aos mais variados bens duráveis por parte dos domicílios. Dessa forma, este trabalho foi dividido em cinco seções. A primeira visa fazer uma breve revisão da literatura relevante sobre o tema a fim de averiguar até onde estes estudos avançaram e como é possível contribuir de forma significativa a partir do que já foi estudado. A segunda descreve a base de dados utilizada enquanto a terceira faz um breve relato de como a desigualdade de renda, da despesa e do acesso a crédito evoluiu nos últimos 25 anos. A quarta, por sua vez, busca mostrar como os domicílios brasileiros, divididos por decis de renda e por ano, estão estocados de bens duráveis. Por fim, a última sessão mostrará quais foram os determinantes do acesso aos mais variados bens duráveis. Dito de outra forma, o trabalho busca decompor os efeitos que as variáveis de renda real, acesso a crédito e preço tiveram sobre a posse dos bens em questão. De forma geral, este trabalho conclui que, embora ainda existente, a desigualdade de acesso a diferentes bens duráveis foi decrescente ao longo do período analisado. Variáveis de renda real, crédito e preço apresentaram contribuições diferentes e significativas cada bem estudado. As evidências são de que, no geral, além de ter havido um aumento da renda real e do acesso ao crédito, os domicílios apresentaram mudanças de preferências intertemporais em relação à posse dos bens. No mais, os domicílios também se mostraram mais sensíveis à renda e a crédito hoje do que num passado recente.

Constructing coincident and leading indices of economic activity for the Brazilian economy

This paper has three original contributions. The fi rst is the reconstruction effort of the series of employment and income to allow the creation of a new coincident index for the Brazilian economic activity. The second is the construction of a coincident index of the economic activity for Brazil, and from it, (re) establish a chronology of recessions in the recent past of the Brazilian economy. The coincident index follows the methodology proposed by The Conference Board (TCB) and it covers the period 1980:1 to 2007:11. The third is the construction and evaluation of many leading indicators of economic activity for Brazil which fills an important gap in the Brazilian Business-Cycle literature.

Persistência inflacionária na América do Sul

Esse trabalho busca analisar empiricamente a persistência inflacionária de um grupo de dez países da América do Sul e verificar se a persistência ficou estável durante o período analisado e se persistência inflacionária é mais alta em países que apresentaram alta inflação no seu passado recente. Os dados são trimestrais, tendo início no primeiro trimestre de 2000, e contém 60 observações. Os resultados do trabalho foram obtidos por meio da estimação dos seguintes modelos: modelo com defasagens de inflação com e sem o hiato do PIB; curva de Phillips Novo-Keynesiana com taxa de câmbio; e a forma reduzida do modelo estrutural de Blanchard e Gali (2005), que incorpora a rigidez de salários. Os resultados mostraram que a persistência inflacionária ficou estável durante o período analisado e que seu nível ficou abaixo de 1, na média, no grupo de países que apresentaram alta inflação no passado recente e no grupo de países que não apresentaram. Além disso, os resultados mostraram que, na amostra selecionada, a persistência inflacionária é mais alta nos países que apresentaram alta inflação no seu passado recente. Também foi verificado que, com 5% de significância, não é possível afirmar que a persistência inflacionária de todos os países que apresentaram alta inflação no passado recente seja diferente das economias que não apresentaram.

Energy education: breaking up the rational energy use barriers

Human development is associated directly or indirectly with the energy use, and because of this the energetic sources were dealt with in the recent past, as fully available to human necessities. The reality shows that the energy availability, considering the nonrenewable sources, is limited, and beyond that, the exploration, the processing and the use of energy impose considerable impacts on the environment. There is not a system which operates with no losses and without imposing changes to the environment. Therefore, the energy conservation incorporates the concepts and the actions applied to the research of sustainable balance between nature and the energy availability and use. Such actions can be presented both in the short term, in which the energy system is close to a collapse, or in the medium/long term, in which those responsible for the energy policies are concerned with the structure of the socioeconomic development. Such a situation requires more responsibility in the treatment of energy questions, mainly through education, which represents long-term investments. This paper discusses barriers that are present in the projects applied to energy conservation, by making clear that education is one of the best ways to transform the human behavior in for the rational use of energy. (C) 2003 Elsevier B.V. Ltd. All rights reserved.

An overview of biodiesel soil pollution: Data based on cytotoxicity and genotoxicity assessments

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)