INFOBIOMED: European Network of Excellence on Biomedical Informatics to support individualised healthcare

INFOBIOMED is an European Network of Excellence (NoE) funded by the Information Society Directorate-General of the European Commission (EC). A consortium of European organizations from ten different countries is involved within the network. Four pilots, all related to linking clinical and genomic information, are being carried out. From an informatics perspective, various challenges, related to data integration and mining, are included.

Teller: telemetría con GPS

En el campo del motociclismo y el automovilismo de competición se debe disponer de tecnología que ayude en la conducción y el aprendizaje del piloto. La telemetría juega un papel que es clave en este aspecto. Gracias a GPS precisos y que ofrecen una gran variedad de información, el piloto puede observar cualquier defecto en su conducción. Sin embargo, la mayor parte de los pilotos que se dedican al motociclismo y el automovilismo de manera amater no puede permitirse la compra de estos dispositivos. A lo largo de este documento se explica el trabajo realizado para crear Teller. Teller es una aplicación que recoge los datos de un GPS de bajo coste, genera información mediante cálculos físicos realizados con Erlang y visualiza dicha información para los pilotos que quierenmejorar. Con esta aplicación se pretende ofrecer una alternativa barata de telemetría sin necesidad de gastarse el dinero en GPS precisos pero demasiado caros. ---ABSTRACT---In the field of motorcycling racing and motorsport technology should be available to assist in driving and learning from the pilot. Telemetry plays a key role in this regard. Thanks to accurate GPS which offer various information, the pilot can see any fault in his driving. However, most of pilots who engage motorcycling racing and motorsport in the amater way can not afford to purchase these devices. Throughout this document the work done to create Teller is explained. Teller is an application that collects data from a low cost GPS, it generates information by physical calculations made in Erlang and it displays this information for pilots who want to improve. This application aims to provide a cheap alternative of telemetry without spending money on accurate but expensive GPS.

Sistema de control de tracción y salida para un monoplaza de la Fórmula SAE

En este proyecto de final de carrera se detalla el proceso de diseño, fabricación, montaje y ajuste de un dispositivo electrónico que sirva como sistema de control de tracción de un vehículo y que acoplaremos sobre un monoplaza de carreras que participa en la competición Formula SAE. La Formula SAE (Society of Automotive Engineers - Sociedad de Ingenieros de Automoción), es una competición de coches de carreras monoplaza a nivel universitario que promueve el desarrollo de la ingeniera aplicada a la automoción. Se pretende que este libro sirva de guía para el correcto manejo y desempeño del sistema fabricado. Además se ha pretendido que su lectura resulte fácil y comprensible para que la persona que lea este libro sea capaz de entender el sistema realizado para así poderlo mejorar. Gracias a la colaboración entre la Escuela Técnica Superior de Ingeniería y Sistemas de Telecomunicación (ETSIST) de la Universidad Politécnica de Madrid (UPM), la Escuela de Ingenieros Industriales de esta misma Universidad (ETSII) y el Instituto Universitario de Investigación del Automóvil (INSIA), se sientan las bases de una plataforma docente en la cual se posibilita la formación y desarrollo de un vehículo tipo formula que participa en la ya mencionada competición Formula SAE. Para ello, se formo en el 2003 el equipo UPMRacing, primer representante español en el evento. El equipo se compone de más de 50 alumnos de la UPM y del Máster de Ingeniería en Automoción del INSIA. Es por tanto, en el vehículo fabricado por el equipo UPMRacing, en el que se pretende instalar este sistema de control de tracción. El control de tracción es un sistema de seguridad del automóvil diseñado para prevenir la perdida de adherencia cuando alguna rueda presenta deslizamiento, bien porque el conductor se excede en la aceleración o bien porque el firme este resbaladizo. La unidad de procesamiento del sistema de control de tracción fabricado lee la velocidad de cada rueda del vehículo mediante unos sensores y determina si existe deslizamiento, en tal caso, manda una señal a la centralita para disminuir la potencia hasta que el deslizamiento disminuya a unos valores controlados. El sistema cuenta con un control remoto que sirve como interfaz para que el piloto pueda manejarlo. Por ultimo, el dispositivo es capaz de conectarse a un bus de comunicaciones CAN para configurar ciertos parámetros. El objetivo del sistema es, básicamente, hacer que el coche no derrape en aceleraciones fuertes; concretamente en las salidas desde parado y al tomar una curva, aumentando así la velocidad en circuito y la seguridad del piloto. ABSTRACT. The purpose of this project is to describe the design, manufacture, assembly and adjustment processes of an electronic device acting as the traction control system (TCS) of a vehicle, that we will attach to a single-seater competition formula SAE car. The Formula SAE (Society of Automotive Engineers) is a graduate-level singleseater racing car competition promoting the development of automotive applied engineering. We also intend this work to serve as a technical user guide of the manufactured system. It is drafted clearly and concisely so that it will be easy for all those to whom it is addressed to understand and subject to further improvements. The close partnership among the Escuela Técnica Superior de Ingeniería y Sistemas de Telecomunicación (ETSIST), Escuela de Ingenieros Industriales (ETSII) of Universidad Politécnica de Madrid (UPM), and the Instituto Universitario de Investigación del Automóvil (INSIA), lays the foundation of a teaching platform enabling the training and development of a single-seater racing car taking part in the already mentioned Formula SAE competition. In this respect, UPMRacing team was created back in 2003, first spanish representative in this event. The team consists of more than 50 students of the UPM and of INSIA Master in Automotive Engineering. It is precisely the vehicle manufactured by UPMRacing team where we intend to install our TCS. TCS is an automotive safety system designed to prevent loss of traction when one wheel has slip, either because the driver exceeds the acceleration or because the firm is slippery. The device’s central processing unit is able to detect the speed of each wheel of the vehicle via special sensors and to determine wheel slip. If this is the case, the system sends a signal to the ECU of the vehicle to reduce the power until the slip is also diminished to controlled values. The device has a remote control that serves as an interface for the pilot to handle it. Lastly, the device is able to connect to a communication bus system CAN to set up certain parameters. The system objective is to prevent skidding under strong acceleration conditions: standing-start from the starting grid or driving into a curve, increasing the speed in circuit and pilot’s safety.

Comunicación y seguridad aérea: incidentes y accidentes causados por el uso incorrecto de la lengua inglesa

Este proyecto consiste en el análisis de accidentes e incidentes aéreos causados por problemas en el lenguaje. Se realiza un estudio acerca de la elección del inglés para las comunicaciones en la aviación comercial. Se analiza la reglamentación actual sobre las competencias lingüísticas aplicadas a pilotos y controladores aéreos en la aviación comercial. Además se estudian los problemas lingüísticos causantes de malentendidos en las comunicaciones entre pilotos y controladores aéreos. Finalmente, se analizan en detalle los accidentes e incidentes de mayor importancia causados por problemas lingüísticos, y en los que estos eran un factor relevante en el accidente. Se explican las soluciones aplicadas para minimizar los malentendidos en las comunicaciones, y además se encuesta a un total de trece pilotos españoles con la finalidad de averiguar cuáles son los acentos que más problemas causan, en qué países es donde se tiene más dificultad para entender las comunicaciones aéreas y con mayor frecuencia se emplea una fraseología incorrecta. ABSTRACT. This project consists in the analysis of aviation accidents and incidents caused by language problems. I study why English was chosen as the language of communications in commercial aviation. I analyze the current rules applied for regulating the communication between pilots and controllers. I also study the main linguistic problems that cause misunderstandings in the communications. A detailed study of the most important accidents and incidents caused by misunderstandings is also carried out. I explain the main solutions applied to eradicate or minimize the misunderstandings that could cause an accident, and I also survey a total of thirteen Spanish pilots to directly know what accents are the most difficult ones to understand, which countries tend to modify the standard phraseology, and in which countries Spanish pilots have more problems when communicating with the controllers.

Molecular and cell biology aspects of plague

A 70-kb virulence plasmid (sometimes called pYV) enables Yersinia spp. to survive and multiply in the lymphoid tissues of their host. It encodes the Yop virulon, a system consisting of secreted proteins called Yops and their dedicated type III secretion apparatus called Ysc. The Ysc apparatus forms a channel composed of 29 proteins. Of these, 10 have counterparts in almost every type III system. Secretion of some Yops requires the assistance, in the bacterial cytosol, of small individual chaperones called the Syc proteins. These chaperones act as bodyguards or secretion pilots for their partner Yop. Yop proteins fall into two categories. Some are intracellular effectors, whereas the others are “translocators” needed to deliver the effectors across the eukaryotic plasma membrane, into eukaryotic cells. The translocators (YopB, YopD, LcrV) form a pore of 16–23 Å in the eukaryotic cell plasma membrane. The effector Yops are YopE, YopH, YpkA/YopO, YopP/YopJ, YopM, and YopT. YopH is a powerful phosphotyrosine phosphatase playing an antiphagocytic role by dephosphorylating several focal adhesion proteins. YopE and YopT contribute to antiphagocytic effects by inactivating GTPases controlling cytoskeleton dynamics. YopP/YopJ plays an anti-inflammatory role by preventing the activation of the transcription factor NF-κB. It also induces rapid apoptosis of macrophages. Less is known about the role of the phosphoserine kinase YopO/YpkA and YopM.

A chloroplast homologue of the signal recognition particle subunit SRP54 is involved in the posttranslational integration of a protein into thylakoid membranes.

The mechanisms involved in the integration of proteins into the thylakoid membrane are largely unknown. However, many of the steps of this process for the light-harvesting chlorophyll a/b protein (LHCP) have been described and reconstituted in vitro. LHCP is synthesized as a precursor in the cytosol and posttranslationally imported into chloroplasts. Upon translocation across the envelope membranes, the N-terminal transit peptide is cleaved, and the apoprotein is assembled into a soluble "transit complex" and then integrated into the thylakoid membrane via three transmembrane helices. Here we show that 54CP, a chloroplast homologue of the 54-kDa subunit of the mammalian signal recognition particle (SRP54), is essential for transit complex formation, is present in the complex, and is required for LHCP integration into the thylakoid membrane. Our data indicate that 54CP functions posttranslationally as a molecular chaperone and potentially pilots LHCP to the thylakoids. These results demonstrate that one of several pathways for protein routing to the thylakoids is homologous to the SRP pathway and point to a common evolutionary origin for the protein transport systems of the endoplasmic reticulum and the thylakoid membrane.

Abordagem experimental para avaliação de manobras de navios em modelos físicos de espaços náuticos.

Em um mercado de comércio internacional cada vez mais competitivo existe a necessidade de a infraestrutura do sistema portuário brasileiro modernizar-se, tornando-se mais eficiente do ponto de vista operacional e com capacidade para receber navios de maior porte. Neste cenário, as técnicas de projeto de espaços náuticos precisam ser revistas, utilizando-se de ferramentas mais sofisticadas que permitam otimizar os dimensionamentos sem deixar de lado as questões da eficiência e, principalmente, da segurança operacional. O presente trabalho apresenta uma abordagem experimental para análise do projeto das dimensões de canais de acesso e bacias portuárias, fundamentada no desenvolvimento de um simulador de manobras de navios em modelo físico de escala reduzida, denominado Simulador Analógico de Manobras SIAMA 2014. Além disso, é proposto um sistema completo para avaliação das condições de manobrabilidade de espaços náuticos portuários, desde a calibração da ferramenta de simulação, até a verificação de cenários complexos e situações de emergência. O SIAMA 2014 e o sistema desenvolvido foram aplicados em um estudo de caso, que contou com a participação de práticos e autoridades portuárias na realização de simulações de manobras para verificação das condições de atracação no novo berço do Terminal Portuário Marítimo de Ponta da Madeira, em São Luís do Maranhão. Os resultados deste estudo foram apresentados e discutidos, de forma a mostrar a importância da utilização de modelos físicos reduzidos na simulação de manobra de navios.

Aviation English: Structure and Importance of an International Airborne Language

In today’s globalized world, air travel is one of the fastest growing markets. Millions of aircrafts take off and then touch down all around the world each day. This well-synchronized symphony, however, is much more complex than it seems, and communication – language - plays a crucial role during a plane’s journey. Misunderstandings and miscommunications can have disastrous effects, so the adoption of a standard phraseology to be used during flight is a means to overcome language barriers, avoid ambiguous expressions and guarantee a safe and effective operation of an aircraft. Little is known about the interaction that goes on between pilots and air traffic controllers (ATCOs), and even though the language of aviation is English, cockpit communication can be hard to understand for people who are not familiar with this specific language. The scope of this thesis is to examine the origins of this uncommon language, the characteristics and peculiarities of air communication and to shed a little light on this mystery called Aviation English.

An old captivity,

A young airmen, an Oxford don, and his daughter are aided on an expedition to the Arctic by Norsemen and their longships of a thousand years before.

Development of an intervention program to encourage shoulder harness use and aircraft retrofit in general aviation aircraft: phases I and II.

Federal Aviation Administration, Office of Aviation Medicine, Washington, D.C.

Human factors aspects of using head up displays in automobiles: a review of the literature.

National Highway Traffic Safety Administration, Washington, D.C.

Driver's enhanced vision systems (DEVS). Final report.

Federal Aviation Administration, Atlantic City International Airport, N.J.

The applicability of commercial glare test devices in the aeromedical certification of pilot applicants. Final report.

Federal Aviation Administration, Washington, D.C.

Record flights /

Mode of access: Internet.

Airplane flying handbook.

"FAA-H-8083-3"--Cover.