Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

Peter J. Caffrey with BMCC players and coach

Peter J. Caffrey is pictured with the BMCC players and coach, winners of the Metropolitan Community College Holiday Tournament. Peter J. Caffrey was Acting President of the College from 1971-1972 and again from 1977-1978. He was Dean of the College under President Milton Bassin before his first stint as Acting President.

Transformações do design gráfico no seriado Peter Punk da Disney

Dissertação apresentada ao Mestrado Acadêmico do Programa de Pós-Graduação em Comunicação da Universidade Municipal de São Caetano do Sul

Day of rest - Peter Fry

[Parte 2: Filme "Day of Rest"]