Concerto No. 4 in G Major for Piano and Orchestra, Op. 58

Soitinnus: Piano, ork.

Poem for Orchestra : La bonne chanson

Soitinnus: Ork.

Concertino for Clarinet and Orchestra

Soitinnus: Klarinetti, ork.

Concertstück in F Minor for Piano and Orchestra Op. 79

Soitinnus: Piano, ork.

Arc : for piano and orchestra

Digitoitu 10. 6. 2008.

Coral Island : for soprano and orchestra

Digitoitu 10. 6. 2008.

Novel Players in the Integrin Signaling Orchestra: TCPTP and MDGI

Metastases are the major cause of cancer deaths. Tumor cell dissemination from the primary tumor utilizes dysregulated cellular adhesion and upregulated proteolytic degradation of the extracellular matrix for progeny formation in distant organs. Integrins are transmembrane adhesive receptors mediating cellcell and cellmatrix interactions that are crucial for regulating cell migration, invasion, proliferation, and survival. Consequently, increased integrin activity is associated with augmented migration and invasion capacity in several cancer types. Heterodimeric integrins consist of an alpha - and beta-subunit that are held together in a bent conformation when the receptor is inactive, but extension and separation of subdomains is observed during receptor activation. Either inside-out or outside-in activation of receptors is possible through the intracellular molecule binding to an integrin cytoplasmic domain or extracellular ligand association with an integrin ectodomain, respectively. Several regulatory binding partners have been characterized for integrin cytoplasmic beta-domains, but the regulators interacting with the cytoplasmic alpha-domains have remained elusive. In this study, we performed yeast two-hybrid screens to identify novel binding partners for the cytoplasmic integrin alpha-domains. Further examination of two plausible candidates revealed a significant coregulatory role of an integrin alpha-subunit for cellular signaling processes. T-cell protein tyrosine phosphatase (TCPTP) showed a specific interaction with the cytoplasmic tail of integrin alpha1. This association stimulated TCPTP phosphatase activity, leading to negative regulation of epidermal growth factor receptor (EGFR) signaling and diminished anchorage-independent growth. Another candidate, mammary-derived growth inhibitor (MDGI), exhibited binding to several different integrin cytoplasmic alpha-tails through a conserved GFFKR sequence. MDGI overexpression in breast cancer cells altered EGFR trafficking and caused a remarkable accumulation of EGFR in the cytoplasm. We further demonstrated in vivo that MDGI expression induced a novel form of anti-EGFR therapy resistance. Moreover, MDGI binding to α-tails retained integrin in an inactive conformation attenuating integrin-mediated adhesion, migration, and invasion. In agreement with these results, sustained MDGI expression in breast cancer patients correlated with an increased 10-year distant disease-free survival. Taken together, the integrin signaling network is far from a complete view and future work will doubtless broaden our understanding further.

Bachelor of Arts, Honours in String Pulling

In reference to the actions of the Board of Governors of the University.

String figures : a study of Cat`s-Cradle in many lands

UANL

La poésie québécoise comme source d’inspiration musicale

La version intégrale de ce mémoire est disponible uniquement pour consultation individuelle à la Bibliothèque de musique de l’Université de Montréal (http://www.bib.umontreal.ca/MU)

La voix et le bruit, processus et parcours de création de mes œuvres.

La version intégrale de ce mémoire [ou de cette thèse] est disponible uniquement pour consultation individuelle à la Bibliothèque de musique de l’Université de Montréal (www.bib.umontreal.ca/MU)

Beweisführung am seidenen Bit-String?

Seit über zehn Jahren wird in der rechtswissenschaftlichen Literatur der Beweiswert elektronischer Signaturen diskutiert. Alle bisherigen Abhandlungen sind jedoch rein theoretischer Natur. Auch beschäftigen sie sich nur mit einem Teil der Problematik, indem sie lediglich einen relativ kurzen Zeitpunkt nach der Signaturerzeugung betrachten. Praktische Erfahrungen mit der Beweisführung mittels elektronisch signierter Dokumente fehlen vollständig. Im Forschungsprojekt "ArchiSig" konnten nun erstmals praktische Erfahrungen gewonnen werden, die zur Schließung beider Lücken beitragen können. Der vorliegende Aufsatz stellt die aus einer Simulationsstudie gewonnenen Erkenntnisse tatsächlicher Beweiserhebungen mit elektronisch signierten Dokumenten dar und zeigt Konsequenzen für die sichere Langzeitaufbewahrung auf.

Virginia Apgar and string music

Virginia Apgar (1909-1974) is one of the most recognized American doctors, worldwide known by his contribution as the developer of the "Apgar test" a method used for the evaluation of newborns all over the world. She had many interests. She was anesthesiologist, a brilliant teacher and researcher, but she also loved lecture, basketball, fishing, golf, philately, and music. She played violin and cello and she interpreted that instruments in various chamber groups. Being motivated by one of her patients, Carleen Hutchinson, a science and music teacher, she made four instruments, viola, violin, cello, and mezzo violin. Nearly twenty years of her death, on October 24 1994, on the occasion of the annual meeting of the American Academy of Pediatrics and the issue by American Postal Service of a stamp honoring her, some of the preferred Dr. Apgar music pieces where performed with the instruments she made. Her life mixed different activities and let invaluable contributions for humanity.