Saint Clare of Assisi: her life and legislation,

Includes bibliographical references

The incidence of corpora amylacea (CA) in the optic nerve of patients with Alzheimer's disease

Corpora amylacea (CA) are spherical or ovoid bodies 50-50 microns in diameter. They have been described in normal elderly brain as well as in a number of neurodegenerative disorders. In this study, the incidence of CA in the optic nerves of Alzheimer's disease (AD) patients was compared with normal elderly controls. Samples of optic nerves (MRC Brain Bank, Institute of Psychiatry) were taken from 12 AD patients (age range 69-94 years) and 18 controls (43-82 years). Optic nerves were fixed in 2% buffered glutaraldehyde, post-fixed in osmium tetroxide, embedded in epoxy resin and then sectioned to a thickness of 2 microns. Sections were stained with toluidine blue. CA were present in all of the optic nerves examined. In addition, a number of similarly stained but more irregularly shaped bodies were present. Fewer CA were found in the optic nerves of AD patients compared with controls. By contrast, the number or irregularly shaped bodies was increased in AD. In AD, there may be a preferential decline in the large diameter fibres which may mediate the M-cell pathway. Hence, the decline in the incidence of CA in AD may be associated with a reduction in these fibres. It is also possible that the irregualrly shaped bodies are a degeneration product of the CA.

Comparison of the anticatabolic effects of leucine and Ca-β-hydroxy-β-methylbutyrate in experimental models of cancer cachexia

Objective: Loss of skeletal muscle is the most debilitating feature of cancer cachexia, and there are few treatments available. The aim of this study was to compare the anticatabolic efficacy of L-leucine and the leucine metabolite β-hydroxy-β-methylbutyrate (Ca-HMB) on muscle protein metabolism, both invitro and invivo. Methods: Studies were conducted in mice bearing the cachexia-inducing murine adenocarcinoma 16 tumor, and in murine C2 C12 myotubes exposed to proteolysis-inducing factor, lipopolysaccharide, and angiotensin II. Results: Both leucine and HMB were found to attenuate the increase in protein degradation and the decrease in protein synthesis in murine myotubes induced by proteolysis-inducing factor, lipopolysaccharide, and angiotensin II. However, HMB was more potent than leucine, because HMB at 50 μM produced essentially the same effect as leucine at 1 mM. Both leucine and HMB reduced the activity of the ubiquitin-proteasome pathway as measured by the functional (chymotrypsin-like) enzyme activity of the proteasome in muscle lysates, as well as Western blot quantitation of protein levels of the structural/enzymatic proteasome subunits (20 S and 19 S) and the ubiquitin ligases (MuRF1 and MAFbx). Invivo studies in mice bearing the murine adenocarcinoma 16 tumor showed a low dose of Ca-HMB (0.25 g/kg) tobe 60% more effective than leucine (1 g/kg) in attenuating loss of body weight over a 4-d period. Conclusion: These results favor the clinical feasibility of using Ca-HMB over high doses of leucine for the treatment of cancer cachexia. © 2014 Elsevier Inc.

Measurement results of d18O, Mg/Ca, and Ti/Ca of sediment cores GeoB10042-1 and GeoB10043-3

The advection of relatively fresh Java Sea water through the Sunda Strait is presently responsible for the low-salinity "tongue" in the eastern tropical Indian Ocean with salinities as low as 32 per mil. The evolution of the hydrologic conditions in the eastern tropical Indian Ocean since the last glacial period, when the Sunda shelf was exposed and any advection via the Sunda Strait was cutoff, and the degree to which these conditions were affected by the Sunda Strait opening are not known. Here we have analyzed two sediment cores (GeoB 10042-1 and GeoB 10043-3) collected from the eastern tropical Indian Ocean off the Sunda Strait that cover the past ~40,000?years. We investigate the magnitude of terrigenous supply, sea surface temperature (SST), and seawater d18O (d18Osw) changes related to the sea level-driven opening of the Sunda Strait. Our new spliced records off the Sunda Strait show that during the last glacial, average SST was cooler and d18Osw was higher than elsewhere in the eastern tropical Indian Ocean. Seawater d18O decreased ~0.5 per mil after the opening of the Sunda Strait at ~10 kyr B.P. accompanied by an SST increase of 1.7°C. We suggest that fresher sea surface conditions have persisted ever since due to a continuous transport of low-salinity Java Sea water into the eastern tropical Indian Ocean via the Sunda Strait that additionally increased marine productivity through the concomitant increase in terrigenous supply.

Die deutschen prosabearbeitungen der legende vom hl. Ulrich,

Inaug.-diss.-Munich.

Batsʻatrutʻiwn chʻapʻutsʻ ew kshṛotsʻ nakhneatsʻ : aṛajnordutʻeamb Epipʻanu, Khorenatsʻwoy ew Shirakatsʻwoy /

Haṛajabanutʻiwn -- Epiphaniou Peri metrōn kai stathmōn = Epipʻanu Haghags chʻaputsʻ ew kshṛotsʻ -- Anania Shirakunoy hamaroghi Haghags kshṛotsʻn ew chʻapʻutsʻ -- Movsisi Khorenatsʻwoy Haghags asparisakan chʻapʻu -- Haghags ěntʻatsʻitsʻ aregakan ew hamaroy chʻapʻutsʻ ěst krkin ōrinakatsʻ Shirakatsʻwoyn -- Batsʻatrutʻiwn chʻapʻuts ew kshṛotsʻ nakhneatsʻ -- Ard i chʻapʻkʻ ew kshiṛkʻ Gaghghiatsʻwotsʻ -- Aṛandzin dasakargutʻiwn kshṛotsʻ ew chʻapʻutsʻ handerdz tachkakan baṛiwkʻ.

Sancti Iuliani Toletanae scolis episcopi opera.

Mode of access: Internet.

Biblīograficheskīĭ ukazatelʹ knig i stateĭ o slovi︠a︡nskikh pervouchiteli︠a︡kh sv. Kirilli︠e︡ i Mefodīi︠e︡ /

At head of title: Izdanīe redakt︠s︡īi zhurnala "Biblīograf."

聖アウグスティヌス懺悔録

Mode of access: Internet.

Sint-Nikolaas en het Sint-Nikolaas-feest.

Mode of access: Internet.

Die Anfänge der christlichen Kirche und ihrer Verfassung. ein geschichtlicher Versuch /

Errata: p. 786.

Vita di Niccolò Bonafede, vescovo di Chiusi, e officiale nella corte romana dai tempi di Alessandro VI ai tempi di Clemente VII.

Mode of access: Internet.

Sacra Moraviae historia. Sive, Vita SS. Cyrilli & Methvdii ... Ex diversis historicorvm tvm impressorvm, tum scriptorum codicibus, ex continuata majorum traditione, & publicis fide dignis instrumentis, atque Romanorum Pontificum bullis, acerbo fudore collecta ...

"Diversa memorabillum monumenta" (p. [583]-628) has special t.p.