Sistemas microemulsionados como carreador lipídico para fármacos insolúveis

Several pharmaceutical products have been developed in recent years aiming to enhance the treatment of diseases by increasing the effectiveness of drugs. Many of these new products are based on new drug delivery systems. Among these, microemulsions, which were first studied in 1943 by Hoar and Schulman, is of great interest. Microemulsion can be defined as a thermodynamically stable, isotropic, translucent and transparent system of two immiscible liquids stabilized by a surfactant film located in the oil / water interface. The aim os this work was the incorporation of Amphotericin B and Simvasatin to a microemulsion system and analyzes its physicochemical properties and their therapeutical activity when incorporated into this system. Some very promising results were achieved as the reduction of the toxicity and maintenance of the efficacy of the Amphotericin B incorpored into a microemulsion, which was demonstrated in the in vitro pharmacotoxicological study. As for the incorporation of Simvastatin in microemulsion, it was observed a significant improvement in the potential antiinflammatory and anti-infective properties when the system was use to treat infected wounds (simvastatin pleiotropic effects). Therefore, it can be concluded that the incorporation of these drugs into microemulsion system reveal the potential of microemulsions as a promising and novel dosage form, qualifying them for future trials in order to make them available in the pharmaceutical market

Algoritmo evolutivo paralelo para o problema de atribuição de localidades a anéis em redes sonet/sdh

The telecommunications play a fundamental role in the contemporary society, having as one of its main roles to give people the possibility to connect them and integrate them into society in which they operate and, therewith, accelerate development through knowledge. But as new technologies are introduced on the market, increases the demand for new products and services that depend on the infrastructure offered, making the problems of planning of telecommunication networks become increasingly large and complex. Many of these problems, however, can be formulated as combinatorial optimization models, and the use of heuristic algorithms can help solve these issues in the planning phase. This paper proposes the development of a Parallel Evolutionary Algorithm to be applied to telecommunications problem known in the literature as SONET Ring Assignment Problem SRAP. This problem is the class NP-hard and arises during the physical planning of a telecommunication network and consists of determining the connections between locations (customers), satisfying a series of constrains of the lowest possible cost. Experimental results illustrate the effectiveness of the Evolutionary Algorithm parallel, over other methods, to obtain solutions that are either optimal or very close to it

Aproveitamento de resíduo de caulim em cerâmica branca

The world market of Kaolin has been growing as new investments for better quality of materials have been applied. This market produces amounts of dross that are put in the environment in a wrong way, causing damages to it. Trying to reduce these damages, researches have been done in an attempt to use kaolin dross in ceramic. The disposal of kaolin dross in the environment by the industries of the states of Rio Grande do Norte and Paraiba have great impact in society. Usually this dross is disposed clandestinely in places like roads, river banks and lands of small cities. The present work shows the characteristics of the kaolin produced by the mining company in Junco do Seridó, Paraiba state, western Seridó, 300 km from Natal, in the border of both states. After that, researches were done to study its physical and the chemistry characteristics, trying to see if it can be used in white ceramic. The samples got were bolted in fabric of 325# . The technological characteristics tried to use it as a product in white ceramic. For that, it was made a haracterization of the subject matter through enlargement analyses, ATG and ATD, elaborating three formulations that were burned in four different temperatures, 1175, 1200, 1250 and 1300 degrees centigrade up to 30 minutes. After the burning, the subjects were submitted to water absorbing tests, linear retreating, apparent porosity, apparent specific mass, resistance to flexibility and MEV. For one of the mixtures it was obtained demanded properties for a semi porous material

Efeito da pressurização com CO2 sobre o pH da água

Durante a fase de desenvolvimento de novos produtos fitossanitários é comumente utilizado o pulverizador a pressão constante, pressurizado com CO2. O gás carbônico pode provocar a acidificação da água e afetar o comportamento do composto que está sendo avaliado. No presente trabalho, amostras de água de 30 diferentes fontes foram pressurizadas com CO2 durante cinco minutos, até 275 kPa (40 lbf/pol.2), e o pH foi medido na água que saiu do bico e na água no inteior do tanque do pulverizador. Os resultados mostraram redução nos valores do pH em toda as amostras . Os valores do pH elevaram-se ligeiramente após a saída da água pelo bico do pulverizador. A redução, em alguns casos, foi marcante, atingindo 4,91 unidades de pH no caso mais drástico. Esses dados levam a recomendar cautela na interpretação dos resultados obtidos com o uso dos pulverizadores pressurizados com o gás carbônico.

Protocolo para ensaios físico-químicos de estabilidade de fitocosméticos

The growing demand for stable, safe and effective cosmetics has required increasingly complex studies by the scientific community and the use of more efficient techniques to determine the stability of these products. The use of active principles from the Brazilian flora has led to the development of numerous products, in the most varied pharmaceutical forms, making it, even more difficult to standardize experimental protocols to certify the stability of cosmetic preparations. While in Brazil there is no one protocol that standardizes the tests that should be carried out to determine product stability, several studies have been conducted in academic laboratories to determine the stability of specific raw materials. The rheological properties of topical use products have to be taken into account in their manufacture, storage and application. The determination of the rheological behavior of a formulation helps in evaluating the physicochemical nature of the vehicle, allowing early signs of physical instability to be detected and thus enabling quality control of the constituents, test formulations and final products. Thermal analysis has also been used to assist in the study of cosmetic stability and differential scanning calorimetry to guide the development of new products. Other tools, such as fluorimetry and laser granulometry can be used to help the study and development of both emulsified and non-emulsified systems. The aim of the present study is to develop a protocol for the investigation of the physical and chemical stability of phytocosmetics - systems containing active compounds extracted from the Brazilian biodiversity.

Estudo comparativo de diferentes cogumelos comestíveis comercializados no Brasil: ação contra radicais livres, espécies reativas e atividade antibacteriana

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Otimização para a obtençao de extrato aquoso de tremoço branco (Lupinus albus L.) adicionado de suco de pitanga

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Realidade virtual aplicada à ergonomia por meio do design participativo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O design na indústria moveleira brasileira e seus aspectos sustentáveis: estudo de caso no pólo moveleiro de Arapongas-Pr

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise territorial dos serviços no Brasil: polarização com frágil dispersão

Incluye Bibliografía

Envolvimento dos usuários no processo de inovação por meio da web 2.0: um estudo de caso na indústria automobilística

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Logística reversa das embalagens de bebidas pós consumo: os sistemas de depósito e a viabilidade de sua implantação no Brasil

Pós-graduação em Engenharia de Produção - FEB

Avaliação do nível de maturidade de empresas automotivas

Pós-graduação em Engenharia Mecânica - FEG

Avaliação crítica da pesquisa clínica no Brasil

Pós-graduação em Patologia - FMB

A intervenção do design nas superfícies projetadas: processos multifacetados e estudos de caso

Pós-graduação em Design - FAAC