Alienated Selfhood and Heroism: A Poststructuralist Reading of John le Carré’s Spy Fiction Novels

John le Carré’s novels “The Spy Who Came in From the Cold” (1963), “Tinker, Tailor, Soldier, Spy” (1974), and “The Tailor of Panama” (1997), focus on how the main characters reflect the somber reality of working in the British intelligence service. Through a broad post-structuralist analysis, I will identify the dichotomies - good/evil in “The Spy Who Came in From the Cold,” past/future in “Tinker, Tailor, Soldier, Spy,” and institution/individual in “The Tailor of Panama” - that frame the role of the protagonists. Each character is defined by his ambiguity and swinging moral compass, transforming him into a hybrid creation of morality and adaptability during transitional time periods in history, mainly during the Cold War. Le Carré’s novels reject the notion of spies standing above a group being celebrated. Instead, he portrays spies as characters who trade off individualism and social belonging for a false sense of heroism, loneliness, and even death.

CHARACTERIZATION AND THERMAL-HYDRAULIC MODELING OF ENGINEERED BARRIERS FOR A CANADIAN DEEP GEOLOGICAL REPOSITORY FOR USED NUCLEAR FUEL

Within Canada there are more than 2.5 million bundles of spent nuclear fuel with another approximately 2 million bundles to be generated in the future. Canada, and every country around the world that has taken a decision on management of spent nuclear fuel, has decided on long-term containment and isolation of the fuel within a deep geological repository. At depth, a deep geological repository consists of a network of placement rooms where the bundles will be located within a multi-layered system that incorporates engineered and natural barriers. The barriers will be placed in a complex thermal-hydraulic-mechanical-chemical-biological (THMCB) environment. A large database of material properties for all components in the repository are required to construct representative models. Within the repository, the sealing materials will experience elevated temperatures due to the thermal gradient produced by radioactive decay heat from the waste inside the container. Furthermore, high porewater pressure due to the depth of repository along with possibility of elevated salinity of groundwater would cause the bentonite-based materials to be under transient hydraulic conditions. Therefore it is crucial to characterize the sealing materials over a wide range of thermal-hydraulic conditions. A comprehensive experimental program has been conducted to measure properties (mainly focused on thermal properties) of all sealing materials involved in Mark II concept at plausible thermal-hydraulic conditions. The thermal response of Canada’s concept for a deep geological repository has been modelled using experimentally measured thermal properties. Plausible scenarios are defined and the effects of these scenarios are examined on the container surface temperature as well as the surrounding geosphere to assess whether they meet design criteria for the cases studied. The thermal response shows that if all the materials even being at dried condition, repository still performs acceptably as long as sealing materials remain in contact.

Good practices in the Enred@te Pilot Project: a digital social network for older adults and Spanish Red Cross volunteers

The Enred@te initiative, created by Red Cross, the Vodafone Foundation and the TECSOS Foundation, emerged as an evolution of a previous project that developed and piloted a video-communication solution with older adults, using a system installed in their own televisions. Following the success of this first initiative, it was decided to advance toward a more flexible, robust, easy-to-use and high-quality solution, producing a social network accessible through tablets. Older adults can use the network to video-communicate with other older adults and stay informed on various topics of interest. Additionally, a new innovation incorporates the participation of virtual volunteers, a part of the network that promotes its use in an inclusive and participative manner. This solution was also piloted in 2014 with positive results and work to turn it into a service that can reach older adults through the Red Cross is currently on-going.

Famílias Unipessoais Idosas: um estudo das redes sociais pessoais de idosos que vivem sós

Objetivos: O presente estudo tem como objetivo analisar as características estruturais, funcionais e relacionais-contextuais das redes sociais pessoais de famílias unipessoais idosas. Metodologia: Utilizámos para recolha de dados um questionário para caracterizar sociodemograficamente a amostra, o Instrumento de Análise da Rede Social Pessoal (versão para idosos) (IARSP-Idosos) (Guadalupe, 2010; Guadalupe e Vicente 2012) e a escala de solidão UCLA (Neto, 1989). Participantes: A amostra é constituída por 567 indivíduos com média de idades de 75,53 anos, maioritariamente do sexo feminino (63,0%; n = 357). Predominam os sujeitos casados (53,7%; n = 304), com filhos (87,8%; n = 498) e em situação de coabitação (n = 450; 79,4%). Contudo, 20,6% (n = 117) vivem sós, constituindo as famílias unipessoais. Resultados: As redes sociais dos idosos têm em média 7,99 elementos, predominantemente familiares (M = 76,89%). Os participantes percecionam um nível elevado de apoio por parte das suas redes. São redes coesas, pouco dispersas e os contactos entre os elementos são frequentes. As mulheres, os indivíduos solteiros, viúvos ou divorciados e os idosos sem filhos têm uma maior probabilidade de viverem sós (p < 0,05) e estes apresentam uma maior probabilidade de necessitar de apoio social formal (p < 0,05). As famílias unipessoais, quando comparadas com os que não vivem sós, apresentam um maior número de campos relacionais e maior proporção de relações de amizade e de vizinhança (p < 0,05). Têm menor perceção de apoio material e instrumental, informativo, companhia social, acesso a novos vínculos e reciprocidade de apoio (p < 0,05). Além disso, referem menor frequência de contactos e uma maior dispersão geográfica (p < 0,05). Nas famílias unipessoais, observou-se a existência de correlações negativas significativas (p < 0,05) entre a percepção de solidão e o tamanho da rede, a proporção das relações familiares na rede, o apoio emocional e informativo e a reciprocidade de apoio. CONCLUSÃO: Os idosos com famílias unipessoais percecionam menor apoio por parte das suas redes, tendo uma maior propensão à solidão. É fundamental, ao longo do ciclo vital, promover a quantidade e qualidade dos vínculos, no sentido de manter a efetividade do suporte das redes mesmo quando se vive só. / Objectives: The present study aims to analyze the structural, functional and relational-contextual characteristics of older single-person households. Methodology: We used as instruments a questionnaire to evaluate sociodemographic data, the Instrumento de Análise da Rede Social Pessoal (version for elderly people: IARSP-Idosos) (Guadalupe, 2010; Guadalupe e Vicente 2012) and the UCLA Loneliness Scale (Neto, 1989). Participants: The sample consists of 567 individuals with an average age of 75.53 years, mostly females (63.0%; n = 357). There is a predominance of married individuals (53.7%; n = 304) with children (87.8%; n = 498). Older people live mainly in cohabitation (n = 450; 79.4%), however 20.6% oh them live alone, constituting one-person households. Results: The elderly personal social networks have 8 elements, on average, with a predominance of family relationships (M = 76.89%). The participants perceived a high level of support from their networks. In general the networks are cohesive, with low dispersion and have frequent contacts. The women, single, widowed or divorced and childless elderly are more likely to live alone (p < 0.05) and to need social services support (p < 0.05). The single-person households, compared with those who do not live alone, have a greater number of relational fields and a higher proportion of friendships and neighborhood relations (p < 0.05). They have a lower perception of material and informative support, social company and acess to new ties and reciprocal support (p < 0.05). They also refer lowest frequency of contacts and a wider geographical dispersion (p < 0.05). In single-person households there was a negative significant correlation between the perception of loneliness and the social network size, the proportion of family relationships in the network, emotional and informational support and reciprocal support. Conclusions: The elderly single-person households perceived less support from their networks and a greater propensity to loneliness. It is critical to promot the quality of ties, rather then their quantity, throughout the life cycle, in order to maintain the network effectiveness even when the person lives alone.

Optimization of aqueous extraction conditions for the recovery of phenolic compounds and antioxidants from lemon pomace

The aim of this study was to optimize the aqueous extraction conditions for the recovery of phenolic compounds and antioxidant capacity of lemon pomace using response surface methodology. An experiment based on Box–Behnken design was conducted to analyse the effects of temperature, time and sample-to-water ratio on the extraction of total phenolic compounds, total flavonoids, proanthocyanidins and antioxidant capacity. Sample-to-solvent ratio had a negative effect on all the dependent variables, while extraction temperature and time had a positive effect only on TPC yields and ABTS antioxidant capacity. The optimal extraction conditions were 95 oC, 15 min, and a sample-to-solvent ratio of 1:100 g/ml. Under these conditions, the aqueous extracts had the same content of TPC and TF as well as antioxidant capacity in comparison with those of methanol extracts obtained by sonication. Therefore these conditions could be applied for further extraction and isolation of phenolic compounds from lemon pomace.

Sistematics, population genetics, propagation and conservation of Picconia azorica (Tutin) Knobl. (Oleaceae)

Tese de Doutoramento, Biologia (Ecologia Vegetal), 24 de Junho de 2013, Universidade dos Açores.

Molecular and biochemical mechanisms involved in the toxicity of a marine cyanobacteria compound on cancer cell lines

In recent years marine biotechnology has revealed a crucial role in the future of bioindustry. Among the many marine resources, cyanobacteria have shown great potential in the production of bioactive compounds with diverse applicability. The pharmacological potential of these organisms has been one of the most explored areas in particular its antibacterial, antifungal and anticancer potential. This work was based on the assessment of potential anticancer compound E13010 F 5.4 isolated from marine cyanobacteria strain Synechocystis salina LEGE 06099. Thus the aim of this work was to explore molecular and biochemical mechanisms underlying the bioactivity detected in human cancer cells, specifically in lines RKO colon carcinoma and HT-29. The isolation of the compound was performed from biomass obtained by large-scale culture. To obtain the compound fractionation was carried and confirmation and isolation performed by Nuclear Magnetic Resonance (NMR), Thin Layer Chromatography (TLC) and High-Performance Liquid Chromatography (HPLC). Cell viability assays were performed based on reduction of 3- (4,5-dimetiltiaziol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) to assess the cytotoxic potential of the compound. From the battery of cell lines RKO (colon carcinoma), HT-29 (colorectal adenocarcinoma), MG-63 (osteosarcoma) and T47D (breast carcinoma) the cell lines RKO and HT-29 were selected for elucidation of mechanisms of cytotoxicity. For the elucidation of the mechanisms involved in cytotoxicity the cell lines RKO and HT29 were exposed to the compound. A genomic approach based in the mRNA expression of genes involved in apoptosis and cell cycle by Real-Time PCR and a proteomic approach based on the separation of proteins by two-dimensional electrophoresis (2DGE) was performed. For mRNA expression were selected the genes RPL8, HPRT1, VDAC, SHMT2, CCNE, CCNB1, P21CIP, BCL-2 and BAD and for proteomics isoelectric focussing between 3 – 10 and molecular weight of 19 – 117 kDa separated by polyacrylamide gels (2DGE). The MTT results confirmed the reduction of the cell viability. The RT-PCR results for the expression of genes studied were not yet fully elucidative. For the cell line RKO there was a significant reduction in the expression of the gene P21CIP, and a tendency for reduction in the BAD gene expression and for increased expression of gene CCNB1, pointing to an effort for cell proliferation. In HT-29 cell line, there was a tendency for increase in the expression of P21CIP and BAD, which may explain the reduction in cell viability. The 2DGE results indicate proteomic patterns with differentially altered spots in the treated and control cells with both qualitative and quantitative differences, and differences in response between the RKO and HT-29 cell lines.

O género e a carreira académica: Uma análise das barreiras organizacionais

A literatura mostra que as mulheres que prosseguem uma carreira académica detêm, comparativamente aos homens, níveis inferiores no que toca à participação em determinadas áreas disciplinares, posição organizacional, produtividade científica e reconhecimento. Este artigo, que resulta de um estudo qualitativo realizado numa universidade portuguesa, centra-se nas barreiras de natureza organizacional que dificultam a progressão das mulheres na carreira académica. Os resultados obtidos demonstram que a dificuldade em aceder às redes informais de relacionamento, o isolamento social e a desvalorização e secundarização da actividade docente são algumas das barreiras mais notadas pelas mulheres para a progressão na carreira académica.

ANALYSIS OF MACROINVERTEBRATE COMMUNITIES IN SEASONAL WETLANDS THROUGH TIME, ACROSS SPACE, AND USING SPECIES TRAITS

Restoration of natural wetlands may be informed by macroinvertebrate community composition. Macroinvertebrate communities of wetlands are influenced by environmental characteristics such as vegetation, soil, hydrology, land use, and isolation. This dissertation explores multiple approaches to the assessment of wetland macroinvertebrate community composition, and demonstrates how these approaches can provide complementary insights into the community ecology of aquatic macroinvertebrates. Specifically, this work focuses on macroinvertebrates of Delmarva Bays, isolated seasonal wetlands found on Maryland’s eastern shore. A comparison of macroinvertebrate community change over a nine years in a restored wetland complex indicated that the macroinvertebrate community of a rehabilitated wetlands more rapidly approximated the community of a reference site than did a newly created wetland. The recovery of a natural macroinvertebrate community in the rehabilitated wetland indicated that wetland rehabilitation should be prioritized over wetland creation and long-term monitoring may be needed to evaluate restoration success. This study also indicated that characteristics of wetland vegetation reflected community composition. The connection between wetland vegetation and macroinvertebrate community composition led to a regional assessment of predaceous diving beetle (Coleoptera: Dytiscidae) community composition in 20 seasonal wetlands, half with and half without sphagnum moss (Sphagnum spp.). Species-level identifications indicated that wetlands with sphagnum support unique and diverse assemblages of beetles. These patterns suggest that sphagnum wetlands provide habitat that supports biodiversity on the Delmarva Peninsula. To compare traits of co-occurring beetles, mandible morphology and temporal and spatial variation were measured between three species of predaceous diving beetles. Based on mandible architecture, all species may consume similarly sized prey, but prey characteristics likely differ in terms of piercing force required for successful capture and consumption. Therefore, different assemblages of aquatic beetles may have different effects on macroinvertebrate community structure. Integrating community-level and species-level data strengthens the association between individual organisms and their ecological role. Effective restoration of imperiled wetlands benefits from this integration, as it informs the management practices that both preserve biodiversity and promote ecosystem services.

Relatório de estágio: Percepções dos idosos face à sua qualidade de vida na Freguesia de Santo Amaro

O planeamento em saúde serve como suporte para as mudanças que se pretendem implementar em qualquer contexto ao nível da saúde, oferecendo o acesso a cuidados de qualidade, aprimorando a eficácia e a eficiência de uma forma contínua a idosos de diferentes realidades. Este projecto realizou-se numa comunidade da Freguesia de Santo Amaro, Concelho de Sousel. O estudo efectivado a esta comunidade sobre “Quais as percepções dos idosos face à sua qualidade de vida”, surgiu com o objectivo de perceber o que era para eles a qualidade de vida. Foi aplicado um inquérito por questionário, a uma amostra de 144 indivíduos, com 65 ou mais anos. Através dos resultados obtidos e das áreas cuja intervenção nos pareceu mais propícias, projectámos um série de actividades que considerámos importantes implementar, de forma a dar o nosso contributo para qualidade de vida desta comunidade. As temáticas consideradas prioritárias, e nas quais pudemos intervir, estão relacionadas com a promoção de estilos de vida saudáveis, assim alguns temas abordados estão relacionados com a Diabetes, HTA, prática de exercícios físico e o combate à solidão. Como profissionais de saúde a trabalhar nas comunidades, temos a percepção de que mudar comportamentos é muito difícil, no entanto, consideramos que ao capacitar o idoso com conhecimentos acerca de promoção de estilos de vida saudáveis, estamos a possibilitar que compare o que faz como os novos conhecimentos, para que possa decidir o que fazer pela sua saúde

Credit application systems for investments in agriculture and livestock in rural areas in Latin America

La falta de recursos para mejorar los insumos y herramientas es causa fundamental de la falta de seguridad alimentaria, según las familias y organizaciones entrevistadas en las Comunidades Marginadas y Aisladas (CMA) en América Latina. Las familias que viven en este tipo de comunidades acceden a los insumos adecuados bien a través de la donación, o a través del crédito. La condición de marginación y aislamiento invita a optar por el crédito, al volverse imprescindible el contar con intervenciones sostenibles por la poca atención que este tipo de comunidades recibe de las autoridades públicas y la cooperación al desarrollo. De entre las metodologías para acceder a los créditos en las CMA destacan las líneas de crédito, los Programas de Grupos Solidarios (PGSs), o las Estructuras Financieras Locales (EFLs) o bancos comunales. Tras el análisis realizado en este artículo, se concluye que las EFLs o bancos comunales son la metodología capaz de arrojar mejores resultados.

Étude des liens entre l’isolement, la psychopathie et l’hostilité avec le risque de récidive chez les délinquants sexuels

La présente recherche vise à cerner les liens entre l’isolement et les traits psychopathiques avec le risque de récidive chez les délinquants sexuels. La littérature scientifique montre que le manque d’intimité, le sentiment de solitude et la psychopathie sont des caractéristiques très présentes chez les délinquants sexuels. Le manque d’intimité et la solitude émotionnelle peuvent être dus à une peur du rejet en lien avec un attachement fragile. D’un autre côté, l’isolement social peut être lié à des déficits relationnels causés par la présence de traits psychopathiques. De plus, le manque d’intimité, la solitude émotionnelle et les traits psychopathiques engendrent de l’hostilité et ont chacun un impact sur la récidive. La présente étude a alors pour objectif de voir les liens entre le manque d’intimité, le sentiment de solitude, les traits psychopathiques et l’hostilité avec le risque de récidive sexuelle et violente tel qu’évalué par la Statique-99. Les résultats font ressortir qu’il n’y a pas de relation entre l’isolement et les traits psychopathiques mais que l’isolement et les traits psychopathiques sont liés à l’hostilité. Les agresseurs sexuels d’adultes sont plus psychopathiques que les agresseurs sexuels d’enfants qui éprouvent plus de solitude émotionnelle. Les traits psychopathiques sont liés à la dimension antisociale et la solitude émotionnelle à la dimension sexuelle de la Statique-99. La solitude émotionnelle et les traits psychopathiques ont une relation distincte avec le risque de récidive chez les agresseurs sexuels.

Étude des liens entre l’isolement, la psychopathie et l’hostilité avec le risque de récidive chez les délinquants sexuels

La présente recherche vise à cerner les liens entre l’isolement et les traits psychopathiques avec le risque de récidive chez les délinquants sexuels. La littérature scientifique montre que le manque d’intimité, le sentiment de solitude et la psychopathie sont des caractéristiques très présentes chez les délinquants sexuels. Le manque d’intimité et la solitude émotionnelle peuvent être dus à une peur du rejet en lien avec un attachement fragile. D’un autre côté, l’isolement social peut être lié à des déficits relationnels causés par la présence de traits psychopathiques. De plus, le manque d’intimité, la solitude émotionnelle et les traits psychopathiques engendrent de l’hostilité et ont chacun un impact sur la récidive. La présente étude a alors pour objectif de voir les liens entre le manque d’intimité, le sentiment de solitude, les traits psychopathiques et l’hostilité avec le risque de récidive sexuelle et violente tel qu’évalué par la Statique-99. Les résultats font ressortir qu’il n’y a pas de relation entre l’isolement et les traits psychopathiques mais que l’isolement et les traits psychopathiques sont liés à l’hostilité. Les agresseurs sexuels d’adultes sont plus psychopathiques que les agresseurs sexuels d’enfants qui éprouvent plus de solitude émotionnelle. Les traits psychopathiques sont liés à la dimension antisociale et la solitude émotionnelle à la dimension sexuelle de la Statique-99. La solitude émotionnelle et les traits psychopathiques ont une relation distincte avec le risque de récidive chez les agresseurs sexuels.

Aspects Related to Venous Ulcer Healing and its Influence on Quality of Life

Nowadays, the varicose ulcers (VUs) are one of the most worrying leg ulcers and are an important problem in global public health, with high costs related to the treatment and its complications. Moreover, the quality of life (QOL) of the patient could be affected by pain, sleep disorders, functional impairment, depression and isolation. The VUs patient care is complex and it is necessary to know the aspects that contribute to the healing process for developing effective strategies. The members of the multidisciplinary health team should identify sociodemographic, clinical and care aspects that interfere in tissue repair and therefore impacting the QOL. Self-efficacy, adherence to treatment and self-esteem are other important aspects also related to healing and QOL, with implications for health care and the multidisciplinary team. To sum up, the use of multidisciplinary protocols allows the systematization of care for people with VUs in order to standardize therapeutic interventions with the aim to decrease the healing process time and, as a consequence, to improve the QOL.

Emotional aspects

Through adolescence, young people are at an exciting point of their maturation. On the whole they are thoughtful, caring and responsible people. In many ways they are just beginning to make valuable contributions to the society they will soon be steering. They are critical and reflective, and they are passionate and energetic. We have discovered in earlier chapters the types of physical and cognitive changes and developments that confront adolescents. In this chapter we will explore emotional and moral development and allied issues of resilience and vulnerability. The emotional dimension of adolescence can tie in with several other issues that extend from aloneness, loneliness and alienation. We will introduce key theory and theorists in the field of emotional and moral development (such as Kohlberg). Some adolescents have a traumatic time (as do people of all ages and phases of life) and this book wouldn’t be whole without a brief discussion of the types of issues that emerge as young people in the throes of developing their moral and emotional perspective of the world are dealt life challenges.