946 resultados para Insuficiência cardíaca Teses
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Ps-graduao em Fisiopatologia em Clnica Mdica - FMB
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Ps-graduao em Bases Gerais da Cirurgia - FMB
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B type natriuretic peptide (BNP) and its precursor, the inactive form of NT-pro-BNP, are currently the most studied laboratory parameters in the heart disease spectrum. The assessment of their blood concentrations provides invaluable information on the likelihood, severity and prognosis of the disease. The present review aims to describe the biological determinants, the factors that influence these peptide concentrations, the suggested cutoff values for the diagnosis of heart failure and the use of this biomarker in the assessment of cardiac function.
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A insuficiência cardíaca (IC) est associada a miopatia dos msculos esquelticos dos membros, com perda da massa muscular, diminuio na proporo das fibras do tipo I (contrao lenta) e aumento na proporo das fibras do tipo II (contrao rpida). provvel que alteraes na expresso de fatores de transcrio pertencentes famlia basic helix-loop-helix (bHLH), da qual fazem parte a MyoD, Miogenina, Myf5 e o MRF-4, conhecidos como fatores de regulao miognica (MRFs), sejam responsveis pelas mudanas nos tipos de fibras. Enquanto que a Miogenina expressa em nveis superiores aos da MyoD em msculos lentos, o oposto verdadeiro para msculos rpidos. Similarmente, a MyoD est associada com a expresso das isoformas de miosina de cadeia pesada rpidas dos tipos IIX e IIB. Estudos in vitro, demonstraram que o TNF- inibe a expresso de MyoD e miogenina diminuindo a atividade de genes msculo especficos. A ao do TNF- diminuindo a expresso da MyoD mostra-se mais acentuada quando em associao com o IFN-, no entanto, h poucas informaes na literatura a respeito do papel desta associao na expresso dos fatores de regulao miognica, in vitro. Avaliar a expresso dos fatores de regulao miognica, MyoD, miogenina, Myf5, e MRF-4 em cultura de mioblastos C2C12 submetidos ao TNF-/IFN-. Nossos resultados mostraram um aumentou na expresso dos gene MyoD, Myf5 e miogenina sob tratamento com IFN- quando comparado aos grupos controle e TNF-/IFN-. A expresso gnica do MRF-4 na cultura de clulas no foi detectada em nenhum dos grupos analisados. O GAPDH foi utilizado para normalizar os valores de expresso dos outros genes analisados. O presente estudo demonstrou que o IFN- exgeno administrado culturas de mioblastos... (Resumo completo, clicar acesso eletrnico abaixo)
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Infective endocarditis is a process in which an infection attacks the heart endothelial surface, and is commonly caused by bacterial colonization, which is called bacterial endocarditis. It is a condition rarely found in dogs and cats, and is more prevalent in male dogs of large size. It mainly affects the left side of the heart, affecting the mitral and aortic valves with greater frequency. The circulation of the bacterium in the bloodstream is what gives rise endocarditis, and is caused by any non-aseptic process that serves as a gateway for bacterium in the body, as from a skin lesion, even as an invasive procedure, such as, catheterization and surgery. The ante-mortem diagnosis is difficult because the clinical signs of endocarditis are varied and common to other diseases, summing up the signs of infection (fever, lethargy, weight loss), and presence of heart murmur and may show signs of congestive heart failure. Thus, the diagnosis is most often through autopsy. To arrive at a diagnosis should be used, besides the history and physical examination, some laboratory tests, especially blood cultures and echocardiography. Treatment is accomplished through the use of antibiotics for long period of time, it is very important to follow the results of susceptibility after its outcome is revealed. The prognosis for bacterial endocarditis ranges from guarded to poor, and can be assessed mainly by the echocardiography. There are few studies in veterinary about the bacterial endocarditis, and the majority is case reports
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Ps-graduao em Medicina Veterinria - FCAV
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)