992 resultados para Illinois. General Assembly. Commission to Visit and Examine State Institutions


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Cover title.

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Mode of access: Internet.

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STUDY OBJECTIVES: Besides their well-established role in circadian rhythms, our findings that the forebrain expression of the clock-genes Per2 and Dbp increases and decreases, respectively, in relation to time spent awake suggest they also play a role in the homeostatic aspect of sleep regulation. Here, we determined whether time of day modulates the effects of elevated sleep pressure on clock-gene expression. Time of day effects were assessed also for recognized electrophysiological (EEG delta power) and molecular (Homer1a) markers of sleep homeostasis. DESIGN: EEG and qPCR data were obtained for baseline and recovery from 6-h sleep deprivation starting at ZT0, -6, -12, or -18. SETTING: Mouse sleep laboratory. PARTICIPANTS: Male mice. INTERVENTIONS: Sleep deprivation. RESULTS: The sleep-deprivation induced changes in Per2 and Dbp expression importantly varied with time of day, such that Per2 could even decrease during sleep deprivations occurring at the decreasing phase in baseline. Dbp showed similar, albeit opposite dynamics. These unexpected results could be reliably predicted assuming that these transcripts behave according to a driven damped harmonic oscillator. As expected, the sleep-wake distribution accounted for a large degree of the changes in EEG delta power and Homer1a. Nevertheless, the sleep deprivation-induced increase in delta power varied also with time of day with higher than expected levels when recovery sleep started at dark onset. CONCLUSIONS: Per2 and delta power are widely used as exclusive state variables of the circadian and homeostatic process, respectively. Our findings demonstrate a considerable cross-talk between these two processes. As Per2 in the brain responds to both sleep loss and time of day, this molecule is well positioned to keep track of and to anticipate homeostatic sleep need. CITATION: Curie T; Mongrain V; Dorsaz S; Mang GM; Emmenegger Y; Franken P. Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation. SLEEP 2013;36(3):311-323.

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1895/96 not published; 1896/97 issued as S. doc. 137, 54th Cong., 2d sess., serial no. 3470; 1896/97-1900/1901 issued as U. S. Office of Experiment Stations, Bulletin no. 50, 61, 83, 93; 1914/15-1916/17 published as pt. I of Report on experiment stations and extension work in the United States; 1953/54-1963/64 issued as U. S. Cooperative State Research Service. CSRS-23, no. 1 [etc.]; 1964/65- as U. S. Cooperative State Research Service. CSRS-15, no no. 1 [etc.]

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On June 29, 1992, the Illinois General Assembly enacted Public Act 87-858 which placed an impending ban on the landfill disposal of "white goods" and required the Illinois Environmental Protection Agency and the Illinois Department of Energy and Natural Resources to establish a Task Force to develop and propose desired statutory, regulatory, and programmatic changes necessary to effectively implement the provisions of the legislation.

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Mode of access: Internet.

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Mode of access: Internet.

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Chairman: Representative Aaron Jaffe.