Retard de llenguatge i adquisició de la morfologia. 'Retardo de lenguaje y adquisición de la morfología'.

Buscar elementos para caracterizar el retardo del lenguaje como trastorno específico del desarrollo, tanto el aspecto de diagnóstico como el de evolución y pronóstico. 2 niños con retardo simple del lenguaje y 2 con retardo severo del lenguaje o disfasia. En la parte teórica expone las aportaciones de diferentes autores sobre la adquisición del lenguaje. Hace una revisión de los trastornos del desarrollo del lenguaje. Da una definición operativa de nociones como retardo simple del lenguaje, retardo severo del lenguaje, disfasia, audiomadurez. En el estudio empírico, realiza un estudio longitudinal sobre la adquisición del artículo, el plural del nombre y el tiempo del verbo. Elabora una evaluación psicológica de los mismos sujetos en la adolescencia. Compara los resultados obtenidos con otros niños con adquisición del lenguaje normal. Observación. Magnetófono. Pruebas ad-hoc. Test de inteligencia Wais. Estudio longitudinal. Investigación comparada. El orden de adquisición de las nociones estudiadas no difiere en los dos grupos. Las nociones morfológicas aparecen en los niños con retraso simple y retraso severo con un MLU superior al que presentan los niños normales en el momento de su adquisición. En la adolescencia los sujetos presentan un nivel intelectual dentro de la normalidad. Todos han conseguido el graduado escolar, excepto uno con retardo severo. Todos, excepto uno con retardo ligero, necesitan refuerzo escolar a lo largo de toda la escolaridad. Todos presentan una adecuada adaptación personal y social.

Very short delays prior to escape from potential predators may function efficiently as adaptive risk-assessment periods

Periods between predator detection and an escape response (escape delays) by prey upon attack by a predator often arise because animals trade-off the benefits such a delay gives for assessing risk accurately with the costs of not escaping as quickly as possible. We tested whether freezing behaviour (complete immobility in a previously foraging bird) observed in chaffinches before escaping from an approaching potential threat functions as a period of risk-assessment, and whether information on predator identity is gained even when time available is very short. We flew either a model of a sparrowhawk (predator) or a woodpigeon (no threat) at single chaffinches. Escape delays were significantly shorter with the hawk, except when a model first appeared close to the chaffinch. Chaffinches were significantly more vigilant when they resumed feeding after exposure to the sparrowhawk compared to the woodpigeon showing that they were able to distinguish between threats, and this applied even when time available for assessment was short (an average of 0.29 s). Our results show freezing in chaffinches functions as an effective economic risk assessment period, and that threat information is gained even when very short periods of time are available during an attack.

Milling performance of north European hull-less barleys and characterization of resultant millstreams

Four hull-less barley samples were milled on a Buhler MLU 202 laboratory mill and individual and combined milling fractions were characterized. The best milling performance was obtained when the samples were conditioned to 14.3% moisture. Yields were 37-48% for straight-run flour, 47-56% for shorts, and 5-8% for bran. The beta-glucan contents of the straight-run white flours were 1.6-2.1%, of which approximate to49% was water-extractable. The arabinoxylan contents were 1.2-1.5%, of which approximate to17% was water-extractable. Shorts and bran fractions contained more beta-glucan (4.2-5.8% and 3.0-4.7%, respectively) and arabinoxylan (6.1-7.7% and 8.1-11.8%, respectively) than the white flours. For those fractions, beta-glucan extractability was high (58.5 and 52.3%, respectively), whereas arabinoxylan extractability was very low (approximate to6.5 and 2.0%, respectively). The straight-run white flours had low alpha-amylase, beta-glucanase, and endoxylanase activities. The highest alpha-amylase activity was found in the shorts fractions and the highest beta-glucanase and endoxylanase activities were generally found in the bran fractions. Endoxylanase inhibitor activities were low in the white flours and highest in the shorts fractions. High flavanoid, tocopherol, and tocotrienol contents were found in bran and shorts fractions.

Zinc chelatase in human lymphocytes: detection of the enzymatic defect in erythropoietic protoporphyria

We describe a fluorometric assay for heme synthetase, the enzyme that is genetically deficient in erythropoietic protoporphyria. The method, which can readily detect activity in 1 microliter of packed human lymphocytes, is based on the formation of zinc protoheme from protoporphyrin IX. That zinc chelatase and ferrochelatase activities reside in the same enzyme was shown by the competitive action of ferrous ions and the inhibitory effects of N-methyl protoporphyrin (a specific inhibitor of heme synthetase) on zinc chelatase. The Km for zinc was 11 micrograms and that for protoporphyrin IX was 6 microM. The Ki fro ferrous ions was 14 microM. Zinc chelatase was reduced to 15.3% of the mean control activity in lymphocytes obtained from patients with protoporphyria, thus confirming the defect of heme biosynthesis in this disorder. The assay should prove to be useful for determining heme synthetase in tissues with low specific activity and to investigate further the enzymatic defect in protoporphyria.

Genetic heterogeneity in erythropoietic protoporphyria: a study of the enzymatic defect in nine affected families

Erythropoietic protoporphyria (EPP) is associated with a deficiency of protohaem ferrolyase. We have used a novel assay for this enzyme based on its ability to utilize zinc as a substrate to investigate the inheritance of EPP in nine affected families. Zinc chelatase activity was markedly reduced in peripheral blood mononuclear cells from 14 EPP patients (mean, 3.3 nmol Zn protohaem/h/mg protein; range, 0.3-8.0) when compared with 41 controls (16.8 +/- 3.6) p less than 0.01. In three families with parent-to-child transmission of disease, the asymptomatic parent had an enzymatic activity within the normal range. In three pedigrees where the parents were asymptomatic, enzymatic activities were below the 95% confidence limits in both. Zinc chelatase activity was below the mean control value in 17 of the 18 parents in nine affected pedigrees, and six of seven asymptomatic offspring of patients with protoporphyria. The findings suggest that EPP is not transmitted as a simple dominant trait and that inheritance of more than one gene may be required for disease expression.

Bargaining over strategies of non-cooperative games

We propose a bargaining process supergame over the strategies to play in a non-cooperative game. The agreement reached by players at the end of the bargaining process is the strategy profile that they will play in the original non-cooperative game. We analyze the subgame perfect equilibria of this supergame, and its implications on the original game. We discuss existence, uniqueness, and efficiency of the agreement reachable through this bargaining process. We illustrate the consequences of applying such a process to several common two-player non-cooperative games: the Prisoner’s Dilemma, the Hawk-Dove Game, the Trust Game, and the Ultimatum Game. In each of them, the proposed bargaining process gives rise to Pareto-efficient agreements that are typically different from the Nash equilibrium of the original games.

Cultura escrita em contextos indígenas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Principais queixas vocais de pacientes idosos pós-tratamento para hanseníase

A hanseníase é uma doença infecto-contagiosa, cujo comprometimento vocal manifesta-se desde rouquidão à dificuldade respiratória. OBJETIVO: Comparar as principais queixas vocais entre pacientes idosos pós-tratamento para hanseníase e um grupo controle. FORMA DE ESTUDO: Descritivo prospectivo. MATERIAL E MÉTODO: Foram incluídos 50 pacientes com idade superior a 60 anos; 32 haviam sido tratados para hanseníase e os demais constituíram o grupo-controle. Houve aplicação de questionário próprio, sendo analisados os sintomas vocais apresentados pelos dois grupos,assim como sexo, faixa etária, hábitos de vida e comorbidades. RESULTADOS: Dentro do grupo pós-tratamento, os sintomas mais frequentes foram pigarro (34,4%) e rouquidão (28,1%), enquanto que no grupo controle os sintomas mais prevalentes foram pigarro (77,8%) e sensação de corpo estranho (55,6%). CONCLUSÃO: Os sintomas vocais mais prevalentes em pacientes pós-tratamento para hanseníase são o pigarro e a rouquidão e sua evolução é influenciada pelos hábitos de vida e por doenças associadas.

Avaliação clínica, videolaringoscópica e vocal perceptivo-auditiva e acústica de professores disfônicos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A educação no contexto diacrônico de antigos núcleos coloniais

This paper provides an overview of the reality of Colonial Corps created in the early twentieth century, in São Paulo, based on a cut of the genesis of the municipality of Peixoto Hawk when he was one of the centers for the accommodation of European immigrants; well as in parallel to the phase coronelismo intensified in the area. From this historical assumption, following a brief contemporary approach, already in the XXI century, in order to provoke a debate that can aggregate relevant contribution to the strategic purposes of the locality, including inserting the new reality imposed by the deployment of the Aerospace Hub in the town, represented by installation of Empresa Brasileira de Aeronautica S / A - Embraer. It takes into account, thus the set of their social and cultural phenomena occurred and developed over time (diachronic); based on an analysis for educational planning, particularly in developing and implementing public policies and projects to new propositions for improvement Local education at different levels.

Limites e contribuições do uso da EME para pesquisas de cunho qualitativo na aquisição do PB

The main objective of this paper is to answer the following question: how can we draw a parallel, during the analysis of the data, between children who are at different moments in the language acquisition process or who belong to different populations (children that are monolingual, bilingual, with language disorders, etc.)? In order to answer this question, we are discussing the advantages and limitations of adopting a measure like MLU, from English Mean Length of Utterance, or EME as it was named in Brazil, proposed by Roger Brown (1973). We intend to verify the effective contribution of these measures to the studies in the area and propose an adaptation in the studies that use a qualitative approach. Firstly, we recall the study of the criteria proposed by Brown (1973), Scliar-Cabral (1976), Parker & Brorson (2005), Parisse & Le Normand (2006), and Araújo (2007), and by scholars of Brazilian Portuguese morphology, like Câmara Jr (2009), Monteiro (2002), and Kehdi (1990), among others. Secondly, from a dialogic-discursive point of view (BAKHTIN, 2006; BAKHTIN/ VOLOSHINOV, 1992, 1981), we provide as an example the research on the plural in the language acquisition process (HILÁRIO, 2010, 2011b, 2012). The reflections made indicate that EME may be a useful measure for the researches on language acquisition. Nevertheless, adaptations should be done and its inherent problems should be taken into account, especially if other factors are considered – like the age, the number of types/occurrences, the maximum limit of items per utterance etc. – although it is not the only parameter of analysis. Considering that EME may vary according to the conditions of production and may not reflect the qualitative changes in the children’s discourse, other factors should be analyzed, like the context of the discourse, the participants involved etc.

Infecção por strigea falconis em buteo magnirostris no Brasil

Background: Buteo magnirostris, popularly known as roadside hawk belongs to the family Accipitridae, Ciconiiformes. The specimen is common throughout Brazil inhabiting open areas, tolerating disturbed areas very well, but avoiding dense forests. The trematodes are common parasites in the intestines of birds of prey, with scant notice of pathogenic infections. However, severe infections of trematodes Strigeidae family have been previously reported as a cause of anemia, diarrhea, enteritis, weight loss and death. This paper aims to report the occurrence of infection in S. Falconis in B. magnirostris diagnosed by post mortem examination. Case: The specimen of B. magnirostris, male, young was sent for necropsy at the Laboratory of Veterinary Pathology, Federal Rural University of Semi-Arid (UFERSA), Mossoró-RN, Brazil. With a history of apathy, anorexia, diarrhea and death in one course of 24 h. The free bird life and even puppy had been captured for training and practice of falconry shortly before the clinical manifestation of infection (time of captivity uninformed). On physical examination ruffled feathers, cachexia and pallor of skeletal muscle was observed. At necropsy there was severe enteritis with petechiae and accumulation of liquid contents into the duodenum. Fifty-two trematodes were found set in duodenal mucosa. The other organs and structures showed no changes. Fragments of all organs were harvested, fixed in 10% formalin buffered, routinely processed for histopathology and stained with hematoxylin and eosin (HE). Parasites were carefully collected, washed in saline, fixed, processed and identified according to the morphology and taxonomy. Histologically, the lesions were restricted to the duodenum and were characterized by melting, severe atrophy and necrosis of the epithelial cells of the intestinal villi; inflammatory infiltrate (consisting of lymphocytes, plasma cells and eosinophils) in the lamina propria, in addition to trematodes infiltrated the mucosa and lamina propria. These were 60-80 mm in diameter, consisted of parenchymal body enclosed by the integument. In some cross sections of the parasite was possible to observe the presence of cecum, testis and uterus, with some variations between sections; there were also yellowish eggs and coated with a delicate membrane. The trematodes contain approximately 1 mm in length and used as morphology and taxonomy has been identified as S. Falconis. Discussion: S. Falconis is a trematode intestinal parasite of birds of prey, with reports of its occurrence in Europe, North America and Central. In neotropical regions is described the occurrence of the subspecies S. Falconis brasiliana. Although the absence of clinical signs is a common pattern, parasitism by trematodes may become evident, common to captivity stress conditions, and thus infections, even for low pathogenic parasites can cause diarrhea, anorexia, weight loss and death, as reported in this paper. A factor that possibly contributed to the scant notice is its small size, which makes the observation of this parasite in analysis of necropsy in non-pathological conditions and also not familiar with the technical laboratories in the morphological shape of the eggs, which creates difficulty in finding the parasite in parasitological analysis in captive animals. Despite being considered poorly pathogenic trematodes, epidemiologically, the presence of the parasite should be considered a health risk to free-living predators, newly captive in parks, zoos, veterinary hospitals, triage center for wildlife and creators, as they may express pathogenicity in immunosuppressed animals. This work contributes to recording the presence S. falconis parasitizing the duodenal mucosa of B. magnirostris in Brazil.