Letter to William Dickson from his niece Jane Hamilton

Letter to William Dickson from his niece Jane Hamilton. Jane thanks her uncle for his kind letter and the 50 pounds that he has sent her. The letter concerns family matters such as her nephew sailing for Calcutta and she assumes that Helen has heard about the death of her grandmother (3 ¼ pages, handwritten), Jan. 2, 1845.

Indenture between the Honourable William Dickson of Dumphries, trustee and executor for the late Honourable Robert Hamilton Dickson to Samuel Street of Stamford

Indenture between the Honourable William Dickson of Dumphries, trustee and executor for the late Honourable Robert Hamilton Dickson to Samuel Street of Stamford for 50 acres in the Township of Gainsboro consisting of part of no. 27 in the 2nd Concession – instrument no. 599, Dec. 30, 1841.

El lenguaje vectorial en geometría : los pioneros William Rowan Hamilton y Herman Günther Grassmann.

Resumen del autor. Este artículo pertenece a un número en homenaje a Gonzalo Sánchez Vázquez

Active site mutant transgene confers tolerance to human β-glucuronidase without affecting the phenotype of MPS VII mice

Mucopolysaccharidosis type VII (MPS VII; Sly syndrome) is an autosomal recessive lysosomal storage disorder due to an inherited deficiency of β-glucuronidase. A naturally occurring mouse model for this disease was discovered at The Jackson Laboratory and shown to be due to homozygosity for a 1-bp deletion in exon 10 of the gus gene. The murine model MPS VII (gusmps/mps) has been very well characterized and used extensively to evaluate experimental strategies for lysosomal storage diseases, including bone marrow transplantation, enzyme replacement therapy, and gene therapy. To enhance the value of this model for enzyme and gene therapy, we produced a transgenic mouse expressing the human β-glucuronidase cDNA with an amino acid substitution at the active site nucleophile (E540A) and bred it onto the MPS VII (gusmps/mps) background. We demonstrate here that the mutant mice bearing the active site mutant human transgene retain the clinical, morphological, biochemical, and histopathological characteristics of the original MPS VII (gusmps/mps) mouse. However, they are now tolerant to immune challenge with human β-glucuronidase. This “tolerant MPS VII mouse model” should be useful for preclinical trials evaluating the effectiveness of enzyme and/or gene therapy with the human gene products likely to be administered to human patients with MPS VII.

Register of the Inferior Court, 1759-1763

Contains the Inferior Court's register of debtor's cases heard for the Mayor's Court for the following counties: Orange County, Suffolk County, Westchester County, Ulster County, Duchess County, and Queens County, in New York state. The register, kept by William Wickham, cites parties to the action, sentencing, court costs, and has a name index at the end.