Limitations of the isolated GP-STN network

An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.

The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides

The drug efflux pump P-glycoprotein (P-gp) (ABCB1) confers multidrug resistance, a major cause of failure in the chemotherapy of tumours, exacerbated by a shortage of potent and selective inhibitors. A high throughput assay using purified P-gp to screen and characterise potential inhibitors would greatly accelerate their development. However, long-term stability of purified reconstituted ABCB1 can only be reliably achieved with storage at -80 °C. For example, at 20 °C, the activity of ABCB1 was abrogated with a half-life of <1 day. The aim of this investigation was to stabilise purified, reconstituted ABCB1 to enable storage at higher temperatures and thereby enable design of a high throughput assay system. The ABCB1 purification procedure was optimised to allow successful freeze drying by substitution of glycerol with the disaccharides trehalose or maltose. Addition of disaccharides resulted in ATPase activity being retained immediately following lyophilisation with no significant difference between the two disaccharides. However, during storage trehalose preserved ATPase activity for several months regardless of the temperature (e.g. 60% retention at 150 days), whereas ATPase activity in maltose purified P-gp was affected by both storage time and temperature. The data provide an effective mechanism for the production of resilient purified, reconstituted ABCB1.

A data structure for improved gp analysis via efficient computation and visualisation of population measures

Population measures for genetic programs are defined and analysed in an attempt to better understand the behaviour of genetic programming. Some measures are simple, but do not provide sufficient insight. The more meaningful ones are complex and take extra computation time. Here we present a unified view on the computation of population measures through an information hypertree (iTree). The iTree allows for a unified and efficient calculation of population measures via a basic tree traversal. © Springer-Verlag 2004.

Using DEA to estimate potential savings at GP units at medical specialty level

The aim of this paper is to identify benchmark cost-efficient General Practitioner (GP) units at delivering health care in the Geriatric and General Medicine (GMG) specialty and estimate potential cost savings. The use of a single medical specialty makes it possible to reflect more accurately the medical condition of the List population of the Practice so as to contextualize its expenditure on care for patients. We use Data Envelopment Analysis (DEA) to estimate the potential for cost savings at GP units and to decompose these savings into those attributable to the reduction of resource use, to altering the mix of resources used and to those attributable to securing better resource 'prices'. The results reveal a considerable potential for savings of varying composition across GP units. © 2013 Elsevier Ltd.

Hiánygazdaság - többletgazdaság. Tanulmány a piac elméletéről - I. rész = Shortage economy surplus economy. A study on market theory I

A főáramlat közgazdászai elismerik, hogy a szocialista rendszert a krónikus hiány jellemezte, de úgy vélik, hogy a kapitalista rendszerben - kisebb vagy nagyobb ingadozások közepette - piaci egyensúly uralkodik. Ezzel szemben a tanulmány két piaci állapotot állít egymással szembe. Az egyikben dominálnak a túlkeresleti jelenségek, bár előfordulnak túlkínálati jelenségek is, ezt nevezi a szerző hiánygazdaságnak. A másikban dominálnak a túlkínálati jelenségek, bár előfordulnak túlkeresleti jelenségek is, amit a szerző többletgazdaságnak nevez. A hiánygazdaságot magyarázó tényezőket a szerző korábbi munkái írták le. A jelen tanulmány I. része azokat a mechanizmusokat mutatja be, amelyek a kapitalizmus keretei között létrehozzák a többletgazdaságot: a korlátozott verseny, a schumpeteri "teremtő rombolás", a vállalat törekvése biztonsági tartalékok kiépítésére és a növekvő skálahozadék. Foglalkozik azokkal a jelenségekkel, amelyek fékezik a kereslet és az árak alkalmazkodását. Külön fejezet tárgyalja a többlet mérésének (és ezzel szoros összefüggésben a fogalmak szigorú definícióinak) nehézségeit. ______ Mainstream economists recognize that the socialist system was marked by chronic shortage, but they consider that the capitalist system exhibits market equilibrium, give or take some greater or lesser fluctuations. This study, however, contrasts two market states. One is dominated by phenomena of excess demand, though instances of excess supply appear as well; this the author calls a shortage economy. The other is dominated by phenomena of excess supply, though instances of excess demand appear as well; this the author terms a surplus economy. The author has described in earlier works the factors explaining the shortage economy. Part I of the study presents the mechanisms generating a surplus economy under capitalism: imperfect competition, Schumpeterian "creative destruction" , the efforts of firms to build up safety reserves, and increasing economies of scale. It also covers phenomena that curb accommodation of demand and prices. Discussed in a separate chapter are the difficulties of measuring surplus (and closely tied with this, of strictly defining the concepts).

Hiánygazdaság − többletgazdaság. Tanulmány a piac elméletéről – II. rész = Shortage economy - surplus economy. A study on market theory II

A főáramlat közgazdászai elismerik, hogy a szocialista rendszert a krónikus hiány jellemezte, de úgy vélik, hogy a kapitalista rendszerben - kisebb vagy nagyobb ingadozások közepette - piaci egyensúly uralkodik. Ezzel szemben a tanulmány két piaci állapotot állít egymással szembe. Az egyikben dominálnak a túlkeresleti jelenségek, bár előfordulnak túlkínálati jelenségek is, ezt nevezi a szerző hiánygazdaságnak. A másikban dominálnak a túlkínálati jelenségek, bár előfordulnak túlkeresleti jelenségek is, amit a szerző többletgazdaságnak nevez. A tanulmány II. része összefoglalja a tanulmány fő állításait. Ezek szerint a szocialista rendszer veleszületett immanens tulajdonsága a hiánygazdaság, míg a kapitalista rendszer veleszületett immanens tulajdonsága a többletgazdaság létrehozása és állandó reprodukciója. Állami beavatkozások erősíthetik vagy gyengíthetik ezeket a genetikus tulajdonságokat, de nem szüntethetik meg. A tanulmány áttekinti a többletgazdaság kedvező és kedvezőtlen hatásait. A kedvező hatások között különleges nyomatékkal emeli ki, hogy a többlet (elsősorban többletkapacitások) nélkül nem alakulhat ki a termelők, illetve az eladók rivalizálása, ami az innovációs folyamat legfontosabb hajtóereje. A többletgazdaság általános esetének vizsgálata után különböző speciális esetekkel foglalkozik a tanulmány: a gazdaság konjunkturális hullámzásával, a hadigazdasággal, a modern kapitalizmusban mutatkozó történelmi léptékű változásokkal, valamint a szocialista rendszeren belül megjelent piacorientált reformokkal és a posztszocialista átmenettel. ____ Mainstream economists recognize that the socialist system was marked by chronic shortage, but they consider that the capitalist system exhibits market equilibrium, give or take some greater or lesser fluctuations. This study, however, contrasts two market states. One is dominated by phenomena of excess demand, though instances of excess supply appear as well; this the author calls a shortage economy. The other is dominated by phenomena of excess supply, though instances of excess demand appear as well; this the author terms a surplus economy. Part II of the study starts by summing up its main propositions. Just as the shortage economy is an intrinsic, immanent trait of the socialist system, so the creation and continual reproduction of the surplus economy is an intrinsic, immanent trait of the capitalist system. Such genetic traits may be strengthened or weakened by state intervention, but not eliminated by it. The study reviews the favourable and detrimental effects of the surplus economy. Of the favourable effects, it is emphasized that without surplus there cannot develop among producers or sellers the rivalry that provides the main impetus for the innovation process. Having examined the general case of the surplus economy, the study turns to various special cases: to the trade-cycle fluctuations of the economy, the war economy, the historic changes appearing in modern capitalism, the market-oriented reforms that appear within the socialist system, and the post-socialist transition.

A hiány újratermelése (The reproduction of shortage)

Sporadic lack of consumer articles, the housing shortage, disturbances of material supply, and shortages of investment goods and of labour may be traced back to a common main cause. Shortage is constantly reproduced by specific features of the economic mechanism. The first part of the article consists of micro-analysis, mainly of the productive enterprise. Efforts to increase production may run up against ceilings of three kinds: constraints on physical resources, constraints on demand, and the budget constraint on enterprises. It is an important feature of a system which of these constraints takes effect. Resource-constrained systems can be distinguished from demand-constrained ones here. In the former, production is limited by production bottlenecks, in the latter by buyer demand. The socialist economy in its "classical" form belongs to the former type. It is related to whether the budget constraint on the enterprise is "hard" or "soft". If hard, enterprise spending is limited by its financial scope, if soft (its losses offset almost automatically) its demand becomes almost insatiable. The second part performs a macro-analysis, showing the mechanism of "suction" with the aid of a hydraulic analogy. The enterprise sector "pumps away" reserves and surpluses of the system, mainly due to the "investment hunger" that appears in the wake of expansionist efforts. Finally the article discusses briefly the interrelations between shortage and inflation.