No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats

Background: Exacerbated oxidative stress is thought to be a mediator of arterial hypertension. It has been postulated that creatine (Cr) could act as an antioxidant agent preventing increased oxidative stress. The aim of this study was to investigate the effects of nine weeks of Cr or placebo supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats (SHR). Findings: Lipid hydroperoxidation, one important oxidative stress marker, remained unchanged in the coronary artery (Cr: 12.6 +/- 1.5 vs. Pl: 12.2 +/- 1.7 nmol.mg(-1); p = 0.87), heart (Cr: 11.5 +/- 1.8 vs. Pl: 14.6 +/- 1.1 nmol.mg(-1); p = 0.15), plasma (Cr: 67.7 +/- 9.1 vs. Pl: 56.0 +/- 3.2 nmol.mg(-1); p = 0.19), plantaris (Cr: 10.0 +/- 0.8 vs. Pl: 9.0 +/- 0.8 nmol.mg(-1); p = 0.40), and EDL muscle (Cr: 14.9 +/- 1.4 vs. Pl: 17.2 +/- 1.5 nmol.mg(-1); p = 0.30). Additionally, Cr supplementation affected neither arterial blood pressure nor heart structure in SHR (p > 0.05). Conclusions: Using a well-known experimental model of systemic arterial hypertension, this study did not confirm the possible therapeutic effects of Cr supplementation on oxidative stress and cardiovascular dysfunction associated with arterial hypertension.

Searching for chronic hepatitis B patients in a low prevalence area – role of racial origin

Abstract Background Clinical studies for testing new drugs against hepatitis B ought to be carried out in low prevalence areas despite difficulties on patient recruitment. In such areas, relatives of chronic hepatitis B patients are considered to be at risk of acquiring the hepatitis B virus (HBV). The aim of this study was to evaluate the prevalence of HBV markers (anti-HBc, HBsAg and anti-HBs) in familial members of chronic hepatitis B (CHB) patients according to their origin (Asian or Western) in a low prevalence area, the city of São Paulo, Brazil. Methods Twenty three Asian CHB probands and their 313 relatives plus 31 CHB probands of Western origin and their 211 relatives were screened for HBV serological markers; the study was carried out in the outpatient clinic of the University of São Paulo School of Medicine. Results Mother to child transmission was greater in the Asian group whereas sexual transmission was more frequent in the Western group (p < 0.0001). Anti-HBc was positive in 90% and 57% of the Asian and Western parents (p = 0.0432) and in 97% and 33% of the Asian and Western brothers (p = 0.0001), respectively. HBsAg was more frequent among the Asian (66%) than the Western (15%) mothers (p = 0.0260) as well as among the Asian (81%) than the Western (19%) brothers (p = 0.0001). We could detect 110 new HBsAg-positive subjects related to the 54 index patients, being the majority (81%) of Asian origin. Conclusion In low prevalence area of hepatitis B, family members and household contacts of chronic HBV carriers are at high risk for acquiring hepatitis B.

Geodynamic events reconstructed in the Betic, Maghrebian, and Apennine chains (central-western Tethys)

A synthetic study has been made to identify main tectono-sedimentary and geodynamic events in central-western Tethys. For this, an interdisciplinary analysis has been performed on successions belonging to tectonic units derived from Betic-Maghrebian-southern Apennine “Flysch basin” domain. The stratigraphic records of the internal, external, and mixed successions deposited in lateral basins of different chains show very similar characters, especially regarding: (a) lithostratigraphy and ages; (b) kind and provenance of supplies (immature and supermature petrofacies from internal and external margins, respectively); (c) presence of “mixed successions” (composed of alternating internal and external petrofacies) attesting to clear palaeogeographic relationships between opposite depositional systems; and (d) timing of the deformation. In addition, specific lithofacies reveal correspondence with similar sedimentary events, such as: (1) very thick silicoclastic supply concentrated in restricted time ranges indicating the main deformational phases in the margin/basin systems; (2) levels rich in black-shales, glauconian, siliceous-producers, and volcaniclastic intercalations, widespread in the studied successions and linked to particular events at the Tethyan scale (anoxic periods, starvation-upwelling, acid-intermediate penecontemporaneous volcanic activity, respectively). Tectonic influence has also been recorded by means of unconformities and tectofacies (such as turbidites, slumps, or olisthostromes, etc.), being correlated with the main deformational phases. Similar stratigraphic and tectonic events have also been found in the Calvana unit of Val Marecchia nappe (Ligurides, northern Apennine). Correlations of stratigraphic and tectonic events support the proposal of an evolutionary geodynamic model involving the presence of a “Mesomediterranean microplate” in intermediate position during Africa-Europe convergence. The closure of central-western Tethys occasioned the Betic-Maghrebian-southern Apennine oceanic branch deformation and the birth of perimediterranean chains during middle-late Miocene.

Bulletin du Muséum national d'histoire naturelle.

t.5 1899

Engineering news.

Mode of access: Internet.

Extension of the Appalachian Regional Commission and the title V regional commissions [microform] : hearings before the Subcommittee on Regional and Community Development of the Committee on Environment and Public Works, United States Senate, Ninety-sixth Congress, first session, on S. 834 ... S. 835 ....

Reuse of record except for individual research requires license from Congressional Information Service, Inc.

Ioannis Alberti Fabricii ... Bibliotheca graeca : sive, Notitia scriptorvm vetervm graecorvm qvorvmcvmqve monvmenta integra avt fragmenta edita exstant tvm plerorvmqve e mss. ac deperditis ab avctore tertivm recognita et plvrimus locis avcta.

Title of v. 12: ... Volvmen dvocedimvm in qvo continentur Leonis Allatii Diatriba de Georgiis et eorvm scriptis atqve libri VI capita qvatvor priora qvibus enarrantvr collectiones canonvm veteris ecclesiae et conciliorvm tam vniversalivm qvam particvlarivm, nec non de epistolis ac decretis pontificvm rom. notitia traditvr. Accedit Synodicvm vetvs, pridem in lvcem datvm a B.D. Ioanne Pappo.

L'Europe et la re̲volution franc̲aise /

1. ptie.] Les moeurs politiques et les traditions. 1885.--2. ptie. La chute de la royaute̲. 1887.--3. ptie. La guerre aux rois. 1792-1793. 1891.--4. ptie. Les limites naturelles, 1794-1795. 1892.--5. ptie. Bonaparte et le Directoire, 1795-1799. [3. e̲d.] 1903.--6. ptie. La tre̲ve--Lune̲ville et Amiens, 1800-1805. 3. e̲d. 1903.--7. ptie. Le blocus continental--le grand empire, 1806-1812. 2. e̲d. 1904.--8. ptie. La coalition, les traite̲s de 1815, 1812-1815. 2. e̲d. 1904.--[9]. Table alphabe̲tique.

Engineering news-record.

Mode of access: Internet.

Indochinese refugees : hearings before the Subcommittee on Asian and Pacific Affairs of the Committee on Foreign Affairs, House of Representatives, Ninety-sixth Congress, first session.

Hearings held Apr. 5-June 13, 1979.

日蓮上人一代圖會

Mode of access: Internet.

日本百将伝一夕話

Mode of access: Internet.

Tableau général de l'empire othoman, : divisé en deux parties, dont l'une comprend la législation mahométane; l'autre, l'histoire de l'empire othoman. /

Comprises only the "Législation mahométane." The history is still unpublished. cf. J. M. Quérard. La France littéraire.

The idler.

Weekly essays first published in the Universal chronicle, or Weekly gazette, Apr. 15, 1758 to Apr. 5, 1760. Of the 103 numbers twelve were contributed by friends; of these no. 33, 93 and 96 by Thomas Wharton; no. 67 by Bennet Langton; no. 76, 79 and 82 by Reynolds.

"Clear-cutting" practices on national timberlands. Hearings, Ninety-second Congress, first session ...

Errata slip inserted.