The life and times of Sir George Grey, K.C.B.,

Mode of access: Internet.

Philosophical miscellanies : translated from the French of Cousin, Jouffroy, and B. Constant. With introductory and critical notices. By George Ripley ...

Mode of access: Internet.

Correspondence of Lieut-General the Hon, Sir George Cathcart, K. C. B.,

Mode of access: Internet.

Remarks concerning the recent visit of Leiutenant General George Digby Barker, C. B., and the diary of Leiutenant John Barker of the Fourth (King's own) regiment during the siege of Boston /

"Reprinted from the Publications of the Colonial society of Massachusetts, vol. v".

Essays and reviews of George Eliot not hitherto reprinted; together with an introductory essay on the genius of George Eliot by Mrs. S. B. Herrick.

Mode of access: Internet.

The life and letters of George William Frederick, fourth earl of Clarendon, K. G., G. C. B.

Mode of access: Internet.

Engine 5, July 1911 (see neg 278b in box 2): crew left to right: Enos DeYoung, engineer; Niel McClein, conductor; Neil B. McLean, brakeman; Ike Shaefer, fireman; George Albertson, brakeman

from left: 1 - Wm. Tate, conductor, on pilot [others unidentified]

Memoir of Sir George Grey, bart., G.C.B.,

Mode of access: Internet.

The life of Sir George Pomeroy--Colley, K. C. S. I., C. B., C. M. G., 1835-1881;

Mode of access: Internet.

Susan B. Anthony statue placed in front of George M. Cohan statue for NOW conference

General note: Title and date provided by Bettye Lane.

S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice.

Purpose To study the protective effects and underlying molecular mechanisms of SAMC on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in the mouse model. Methods Mice were intraperitoneally injected with CCl4 (50 μl/kg; single dose) to induce acute hepatotoxicity with or without a 2-h pre-treatment of SAMC intraperitoneal injection (200 mg/kg; single dose). After 8 h, the blood serum and liver samples of mice were collected and subjected to measurements of histological and molecular parameters of hepatotoxicity. Results SAMC reduced CCl4-triggered cellular necrosis and inflammation in the liver under histological analysis. Since co-treatment of SAMC and CCl4 enhanced the expressions of antioxidant enzymes, reduced the nitric oxide (NO)-dependent oxidative stress, and inhibited lipid peroxidation induced by CCl4. SAMC played an essential antioxidative role during CCl4-induced hepatotoxicity. Administration of SAMC also ameliorated hepatic inflammation induced by CCl4 via inhibiting the activity of NF-κB subunits p50 and p65, thus reducing the expressions of pro-inflammatory cytokines, mediators, and chemokines, as well as promoting pro-regenerative factors at both transcriptional and translational levels. Conclusions Our results indicate that SAMC mitigates cellular damage, oxidative stress, and inflammation in CCl4-induced acute hepatotoxicity mouse model through regulation of NF-κB. Garlic or garlic derivatives may therefore be a potential food supplement in the prevention of liver damage.

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1–3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region4, 5, 6, 7, 8, 9, 10, 11. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods—recursive partitioning and regression...