Treatment Effects Produced by Fränkel Appliance in Patients with Class II, Division 1 Malocclusion

The purpose of this investigation was to evaluate the dentoalveolar and skeletal cephalometric changes produced by the Fränkel appliance in individuals with a Class II, division 1 malocclusion. Lateral cephalograms of 44 patients of both sexes were divided in two groups of 22 each. The control group was comprised of untreated Class II children with an initial mean age of eight years and seven months who were followed without treatment for a period of 13 months. The Fränkel group had an initial mean age of nine years and was treated for a mean period of 17 months. Lateral cephalometric headfilms of each patient were obtained at the beginning and end of treatment. The Fränkel appliance produced no significant changes in maxillary growth during the evaluation period, while a statistically significant increase in mandibular length was observed. The maxillomandibular relationship improved mostly because of an increase in mandibular length. In addition, there were no statistically significant differences in the craniofacial growth direction between the Fränkel and the control group, both showing a slight downward rotation of the palatal plane. The Fränkel appliance produced a labial tipping of the lower incisors and a lingual inclination of the upper incisors as well as a significant increase in mandibular posterior dentoalveolar height. It was concluded that the main effects of the Fränkel appliance during this time period were mostly dentoalveolar with a smaller but significant skeletal mandibular effect.

Effects of nitric oxide and arginine vasopressin on water intake induced by central angiotensin II. Part 1

We determined the effects of AT 1 and AT 2 (selective no peptides antagonists angiotensin receptors), arginine vasopressin V 1 receptor antagonist as well as L-arginine, a nitric oxide donor and N W-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, injected into supraoptic nucleus (SON) on water and sodium intake induced by the injection of angiotensin II (ANGII). Male Holtzman rats weighing 200-250 g with canulae implanted into the SON were used. The drugs were injected in 0.5 μL over 30-60 sec. The water intake after injection of saline SAL+SAL 0.15 M NaCl was 0.40±0.1 mL 2 h -1; SAL+ANGII increase water intake. Losartan decreased the water intake induced by ANGII. PD123319 injected prior to produce no change in water intake induced by ANGII. AVPA prior to ANGII reduced the water intake with a less intensity than losartan. L-arginine prior to ANGII decreases the water intake at a same intensity than losartan. L-NAME prior to ANGII potentiated the dipsogenic effect of ANGII. Losartan injected simultaneously with L-arginine prior to ANGII blocked the dipsogenic effect of ANGII. These results confirm the importance of SON in the control of water intake and strongly suggest that AT 1, V 1 receptors interact with nitrergic pathways within the SON influencing the dipsogenic effect of ANGII.

Características morfológicas dentoesqueléticas das más oclusões de classe I, classe II e classe II subdivisão

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Método não radiográfico para o diagnóstico do padrão esquelético classe II hiperdivergente

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação das alterações induzidas pelo aparelho de Herbst no tratamento da má oclusão de classe II de Angle em telerradiografia cefalométrica em norma de 45°

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Enxerto de osso autógeno e barreira de sulfato de cálcio no tratamento de defeitos de furca classe II. Estudo histológico e histométrico em cães

Pós-graduação em Odontologia - FOA

Análise comparativa da infiltração marginal em restaurações de classe II em resina composta com diferentes técnicas de inserção

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação das alterações dentoalveolares e esqueléticas induzidas pelo Ertty System® no tratamento da má oclusão de classe II subdivisão

Pós-graduação em Ciências Odontológicas - FOAR

A discrepância de tamanho dentário, de Bolton, na oclusão normal e nos diferentes tipos de más oclusões, de Angle, bem como sua relação com a forma de arco e o posicionamento dentário

Pós-graduação em Odontologia - FOAR

Efeitos dentoesqueléticos do tratamento da classe II utilizando o aparelho de Herbst associados à mecânica Straight-wire

This study compared the effect of the treatment protocol for correcting Class Il malocclusion using the Herbst appliance followed by full fixed Straigh-wire mechanics, in two populations, one Brazilian and one of North American origin As a untreated control sample the data from the University of Michigan Elementary and Secondary School Growth Study (UMGS) was used. Our sample was composed of 12 males and 12 females, with initial mean age of 12 years 7 months and final mean ages of 15 years and 3 months. The Michigan patients comprised 21 females and 7 males, with an initial mean age of 11 years and 9 months and final mean age of 14 years and 4 months. The control sample was paired in number, sex and age to the treated Michigan sample. ln both treated groups, lateral cephalometric radiographs were obtained before the Herbst appliance was cemented and at the end of the fixed appliance phase, The first comparison involved the Brazil group and the untreated controls, which demonstrated that the association of the Herbst appliance followed by fixed Straight-wire appliances provoked positive effects on the dentofacial complex, improving pre-existing maxillo-mandibular relationships, besides increasing dentoalveolar compensations which contributed to correct the malocclusion. The second comparison, involved the Brazl1ian and North-American patients treated with the same protocol. Although the pre-treatment comparison showed that the two groups were not similar in all aspects, they presented almost identical therapeutic modifications, which indicate that the effect of' treatment was very similar. These results point out that, in Class ll treatment, the combination of Herbst/Straight-wire mechanics produce consistent and systematic effects, correcting or minimizing possible skeletal imbalances

Angiotensin II AT(1) receptor mutants expressed in CHO cells caused morphological change and inhibition of cell growth

To assess the importance of the leucine residues in positions 262 and 265 of the angiotensin AT, receptor for signaling pathways and receptor expression and regulation, we compared the properties of CHO cells transfected with the wild type or the L262D or L265D receptor point mutants. It was found that the two mutants significantly increased the basal intracellular cyclic AMP (cAMP) formation in an agonist-independent mode. The morphology transformation of CHO cells was correlated with the increased cAMP formation, since forskolin, a direct activator of adenylate cyclase mimicked this effect on WT-expressing CHO cells. DNA synthesis was found to be inhibited in these cell lines, indicating that cAMP may also have determined the inhibitory effect on cell growth, in addition to the cell transformation from a tumorigenic to a non-tumorigenic phenotype. However a role for an increased Ca2(+) influx induced by the mutants in non-stimulated cells cannot be ruled out since this ion also was shown to cause transformed cells to regain the morphology and growth regulation. (c) 2005 Elsevier B.V. All rights reserved.

Interação entre a Angiotensina II, Angiotensina-(1-7) e ECA2 em mulheres

A hipertensão arterial sistêmica é uma doença crônica degenerativa de etiologia multifatorial e poligênica, caracterizada pela presença de níveis tensionais elevados, sendo considerada um dos mais importantes fatores de risco para o desenvolvimento das doenças cardiovasculares. Estudos demonstram que cerca de um bilhão de indivíduos apresentam HAS em todo mundo, sendo esta patologia responsável por 7,1 milhões de morte a cada ano. Diversos fatores estão associados ao aumento da incidência da hipertensão arterial, como obesidade, dislipidemias, dieta rica em sal, alterações nos níveis hormonais e sedentarismo. Após o período da menopausa, observa-se significativa elevação nos valores de pressão arterial dessa população, sendo estes similares ou até maiores aos dos homens para esse mesmo período. O sistema renina-angiotensina (SRAA) desempenha importante papel no controle dos sistemas cardiovascular e renal e a angiotensina II é um potente vasoconstritor desse sistema, formado a partir da ação da Enzima Conversora de Angiotensina (ECA). Por outro lado, a recente descoberta da Enzima Conversora de Angiotensina 2 (ECA2), um homólogo da ECA, mudou todo o conceito do SRAA. A ECA 2 é responsável pela formação do peptídeo angiotensina- (1-7) a partir da clivagem do último aminoácido (fenilalanina) da angiotensina II. Recentes evidências têm demonstrado efeitos benéficos da angiotensina-(1-7) para as doenças cardiovasculares através da vasodilatação, efeito anti-arritmogênico, melhora na função contrátil pós-isquemia e inibição da proliferação celular do músculo liso vascular, sendo esses efeitos antagônicos àqueles observados pela angiotensina II. Dessa forma, o objetivo desse estudo foi analisar a atividade da ECA2, concentrações plasmáticas...(Resumo completo, clicar acesso eletrônico abaixo)

Avaliação das alterações dentárias e esqueléticas induzidas pelo uso do aparelho de Herbst no tratamento da classe II na dentadura mista: Revisão sistemática

Objective: evaluate the immediate dental and skeletal changes induced by the Herbst appliance on early treatment of Angle´s Class II malocclusion. Material and Method: several electronic databases such as Scopus, Pub Med, Medline, Cochrane Library, Lilacs and Scielo were searched. The abstracts that fullfilled the selection criteria were selected and those that did not provide enough information about these criteria were selected but the final decision of including them or not on the research, was taken after the complete reading of the article. The selection criteria were: clinical studies with Class II individuals, both male and female, with initial age of 7 to 10 years, treated with the Herbst appliance that analysed the dental and/or skeletal changes evaluated on lateral cephalometric radiographs; researches where the treatment performed did not involve extractions or surgical interventions; studies that included patients without syndromes or health concerns and articles published in English or Portuguese. Results and Conclusions: five articles were selected. The articles showed that significant changes happened in the mandibular sagittal lenght, on facial convexity angle, on maxillo-mandibular relationship, on retroclination of the upper incisors and on distal movement of the upper molars, on proclination of the lower incisors and on extrusion of the lower molars. The appliance exerted a limited effect on the anterior relocation of the maxillary complex and on facial heights. However, more studies about the performance of the Herbst appliance on early treatment of Class II are needed.