951 resultados para Chao, Eduardo
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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The reconstruction of bilateral osteoradionecrosis (ORN) of mandibular defects using a single free bone flap is rarely performed because extensively radiated neck tissue with severe fibrosis is usually unsuitable for vascularized reconstruction. Thirty-one patients with nasopharyngeal carcinoma (NPC) underwent bilateral reconstruction of advanced ORN in the mandible using a single fibular osteocutaneous flap. Clinical factors associated with the operation were assessed, including classification of mandible defects, types of recipient vessels, perioperative complications, and postoperative outcomes. All of the fibular osteocutaneous flaps survived completely, with the exception of 1 inner skin paddle that presented partial necrosis in a reconstruction of through-and-through defects. All patients experienced an improvement in cosmetic results 6 months after the reconstruction, whereas 23 patients experienced improved mouth opening compared to the preoperative condition. Advanced bilateral ORN in patients with NPC could be synchronously reconstructed with a single fibular osteocutaneous flap. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.
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1. Introduction. Eduardo Coutinho represents the development and innovation of the Brazilian documentary. His career is still marked by a novel technique of interviews with participants also mix documentary with other communication techniques, especially fiction and journalism. This article provides a recovery path Coutinho and his major works. 2. Method. A literature review and analysis of filmic discourse is applied to understand the history and languages adopted by Coutinho during his career as a documentary. 3. Who was. Before acting as a documentary, Coutinho has studied law but always acted in theater and visual arts. This discussion presents Coutinho before documentaries. 4. Frames by Eduardo Coutinho. The main works of the documentary are presented, as well as its important features that transform the filmography of director in one of the most important in Brazil. 5. Conclusions. We conclude that Eduardo Coutinho has left a gap in the Brazilian documentary, since his death in 2014. However, their contributions are transformed the genre, as the results presented in the article.
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Eduardo Zamacois (Pinar del Río, 1873- Buenos Aires, 1971) was a main actor of the spanish’s literature and edition movement from the first third of the 20th century. He was the founder of magazines that had a big impact like “Germinal”, introductive of the sicalipsis (“La Vida Galante”) or so innovative that deserved an special chapter in the history of literature (“El Cuento Semanal” e “Los Contemporáneos”). With this work, it is intended to recreate the most significant stages from his autobiography adventure including the new information that offers his non before published letters exchange with his last sentimental partner. As a writer, his work was very popular in his homeland, translated to the world and reissued in Ibero-America. His literature work is based in three different phases. He began with the use of gallant literature (with books like La enferma, Punto negro) and took an adventure with the pays of mystery and irony (El otro, El misterio de un hombre pequñito, La opinion ajena) to finally focused in a narrative style of a realistic kind, that includes social critique (Las raíces). His last published novel in Spain is a portrait of Madrid during its long siege by the nationalist troops (El asedio de Madrid), a profound tribute to the people’s heroism and a declaration of love to the capital, that was his place of residence for a long time. While his exile, that took him to Cuba, New York and Buenos Aires, he worked in the radio, the dubbing industry and in finishing his most detailed bibliography, Un hombre que se va, a valuable document of that time.
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In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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Fil: Castellino, Marta Elena. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras
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Fil: Loyola, María Enriqueta. Universidad Nacional de Cuyo. Facultad de Artes y Diseño
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Fil: Rosas, Sergio Eduardo. Universidad Nacional de Cuyo. Facultad de Artes y Diseño
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Fil: González, Eduardo. Universidad Nacional de Cuyo. Facultad de Artes y Diseño
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Fil: Mastrangelo, Fabiana.
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Fil: González Moretti, Leticia. Universidad Nacional de Cuyo. Facultad de Artes y Diseño
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Fil: Rotella, María Inés. Universidad Nacional de Cuyo. Facultad de Artes y Diseño