ATTITUDES AND PRACTICES OF GENETIC COUNSELORS IN PROVIDING PREDICTIVE TESTING TO MINORS AT RISK FOR LI-FRAUMENI SYNDROME

Li- Fraumeni Syndrome (LFS) is a rare autosomal dominant hereditary cancer syndrome caused by mutations in the TP53 gene that predisposes individuals to a wide variety of cancers, including breast cancer, soft tissue sarcomas, osteosarcomas, brain tumors, and adrenocortical carcinomas. Individuals found to carry germline mutations in TP53 have a 90% lifetime cancer risk, with a 20% chance to develop cancer under the age of 20. Despite the significant risk of childhood cancer, predictive testing for unaffected minors at risk for LFS historically has not been recommended, largely due to the lack of available and effective screening for the types of cancers involved. A recently developed screening protocol suggests an advantage to identifying and screening children at risk for LFS and we therefore hypothesized that this alongside with the availability of new screening modalities may substantiate a shift in recommendations for predictive genetic testing in minors at risk for LFS. We aimed to describe current screening recommendations that genetic counselors provide to this population as well as explore factors that may have influenced genetic counselors attitude and practice in regards to this issue. An online survey was emailed to members of the National Society of Genetic Counselors (NSGC) and the Canadian Association of Genetic Counsellors (CAGC). Of an estimated 1000 eligible participants, 172 completed surveys that were analyzed. Genetic counselors in this study were more likely to support predictive genetic testing for this population as the minor aged (p

Review and analysis of State legislation and reimbursement practices of physician's assistants and nurse practitioners : final report /

Mode of access: Internet.

Review and analysis of State legislation and reimbursement practices of physician's assistants and nurse practitioners : annotated bibliography /

Mode of access: Internet.

Report to the F.T.C. on the use of automatic fuel adjustment clauses and the fuel procurement practices of investor-owned electric utilities.

Primary authors: Michele F. Crown, L. Jorn Dakin, and Douglas W. Webbink.

Principles and practices of network radio broadcasting;

Mode of access: Internet.

Select British eloquence : embracing the best speeches entire, of the most eminent orators of Great Britain for the last two centuries, with sketches of their lives, an estimate of their genius, and notes, critical and explanatory /

Mode of access: Internet.

The advertising handbook; a reference work covering the principles and practices of advertising,

Mode of access: Internet.

The Best short stories of ... and the yearbook of the American short story.

Published: New York : Dodd, Mead, 1926-1932.

The scarcity of grain considered: or, A statement of the impolicy of the late and present price of grain, the consequences resulting from it, and means suggested for its prevention in future: in which the practices of farmers, millers, and bakers, are alluded to, and the insufficiency of the present corn laws fully demonstrated.

Mode of access: Internet.

The best moving pictures of 1922-23, also Who's who in the movies and the Yearbook of the American screen.

Mode of access: Internet.

Credit practices of retailers and financers of furniture and home appliances in two northwest cities.

Bibliography: p. 85-86.

Annual privacy and security audit report on the procedures, policies, and practices of the Department of Law Enforcement for maintaining criminal history record information for the period ending ... /

Description based on: June 30, 1979.

Experiences and practices of placement offices of institutions of higher learning in Illinois with regard to job placement of members of minority groups.

Mode of access: Internet.

Report concerning the billing practices of public utilities providing gas service to consumers in Illinois /

Pursuant to HR 102, this report contains information pertaining to the guidelines that govern the practice of using estimates in issuing utility bills, the methodologies used by utilities in estimating usage, and standards for accuracy of metering devices.