Wipe sampling procedure coupled to LC-MS/MS analysis for the simultaneous determination of 10 cytotoxic drugs on different surfaces.

A simple wipe sampling procedure was developed for the surface contamination determination of ten cytotoxic drugs: cytarabine, gemcitabine, methotrexate, etoposide phosphate, cyclophosphamide, ifosfamide, irinotecan, doxorubicin, epirubicin and vincristine. Wiping was performed using Whatman filter paper on different surfaces such as stainless steel, polypropylene, polystyrol, glass, latex gloves, computer mouse and coated paperboard. Wiping and desorption procedures were investigated: The same solution containing 20% acetonitrile and 0.1% formic acid in water gave the best results. After ultrasonic desorption and then centrifugation, samples were analysed by a validated liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in selected reaction monitoring mode. The whole analytical strategy from wipe sampling to LC-MS/MS analysis was evaluated to determine quantitative performance. The lowest limit of quantification of 10 ng per wiping sample (i.e. 0.1 ng cm(-2)) was determined for the ten investigated cytotoxic drugs. Relative standard deviation for intermediate precision was always inferior to 20%. As recovery was dependent on the tested surface for each drug, a correction factor was determined and applied for real samples. The method was then successfully applied at the cytotoxic production unit of the Geneva University Hospitals pharmacy.

Irregular to regular sampling, denoising and deconvolution

We propose a restoration algorithm for band limited images that considers irregular(perturbed) sampling, denoising, and deconvolution. We explore the application of a family ofregularizers that allow to control the spectral behavior of the solution combined with the irregular toregular sampling algorithms proposed by H.G. Feichtinger, K. Gr¨ochenig, M. Rauth and T. Strohmer.Moreover, the constraints given by the image acquisition model are incorporated as a set of localconstraints. And the analysis of such constraints leads to an early stopping rule meant to improvethe speed of the algorithm. Finally we present experiments focused on the restoration of satellite images, where the micro-vibrations are responsible of the type of distortions we are considering here. We will compare results of the proposed method with previous methods and show an extension tozoom.

Jugement... de la capitainerie royale de Senart qui condamne le nommé Rognon, berger à Gravois, en 50 livres d'amende, pour avoir porté et tiré plusieurs fois nuitamment un fusil dont il a été trouvé muni. Ordonne que la veuve Langlois, fermière audit Gravois, sera solidairement tenue de ladite amende

[Acte. 1781-10-12. Montgeron]

Audit report on America's Agricultural Industrial Heritage Landscape Inc., D/B/A Silos and Smokestacks National Heritage Area, Independent Auditor's Reports, Financial Statements and Supplementary Information, Schedule of Findings and Questioned Costs, December 31, 2004 & 2005

Other Audit Reports - 28E Organizations

Audit report on the City of LeClaire, Iowa for the year ending June 30, 2006

Audit report on the City of LeClaire, Iowa for the year ending June 30, 2006.

Audit of the Wayne-Ringgold-Decatur County Solid Waste Management Commission as of and for the year ended June 30, 2006

Audit of the Wayne-Ringgold-Decatur County Solid Waste Management Commission as of and for the year ended June 30, 2006.

Audit Report on Indian Hills Community College in Ottumwa, Iowa for the year ended June 30, 2006

Audit report on Indian Hills Community College in Ottumwa, Iowa for the year ended June 30, 2006.

Audit report on the Great River Regional Waste Authority for the years ended June 30, 2005 and 2006

Audit report on the Great River Regional Waste Authority for the years ended June 30, 2005 and 2006.

Audit report on the City of Gilbertville, Iowa for the year ended June 30, 2006.

Audit report on the City of Gilbertville, Iowa for the year ended June 30, 2006.

Audit report on the City of Nevada, Iowa for the year ended June 30, 2006.

Audit report on the City of Nevada, Iowa for the year ended June 30, 2006.

Audit report on the City of Atlantic, Iowa for the year ending June 30, 2006

Audit report on the City of Atlantic, Iowa for the year ending June 30, 2006.

Audit report on Kirkwood Community College in Cedar Rapids, Iowa for the year ending June 30, 2006

Audit report on Kirkwood Community College in Cedar Rapids, Iowa for the year ending June 30, 2006.

Audit report on Jasper County, Iowa for the year ended June 30, 2007

Audit report on Jasper County, Iowa for the year ended June 30, 2007

Audit report on the Heart of Iowa Regional Transit Agency, Des Moines, for the year ended June 30, 2006

Audit report on the Heart of Iowa Regional Transit Agency, Des Moines, for the year ended June 30, 2006.