Impact of weight loss on survival after chemoradiation for locally advanced head and neck cancer: secondary results of a randomized phase III trial (SAKK 10/94).

BACKGROUND To analyze the impact of weight loss before and during chemoradiation on survival outcomes in patients with locally advanced head and neck cancer. METHODS From 07/1994-07/2000 a total of 224 patients with squamous cell carcinoma of the head and neck were randomized to either hyperfractionated radiation therapy alone or the same radiation therapy combined with two cycles of concomitant cisplatin. The primary endpoint was time to any treatment failure (TTF); secondary endpoints were locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and overall survival (OS). Patient weight was measured 6 months before treatment, at treatment start and treatment end. RESULTS The proportion of patients with >5% weight loss was 32% before, and 51% during treatment, and the proportion of patients with >10% weight loss was 12% before, and 17% during treatment. After a median follow-up of 9.5 years (range, 0.1 - 15.4 years) weight loss before treatment was associated with decreased TTF, LRRFS, DMFS, cancer specific survival and OS in a multivariable analysis. However, weight loss during treatment was not associated with survival outcomes. CONCLUSIONS Weight loss before and during chemoradiation was commonly observed. Weight loss before but not during treatment was associated with worse survival.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 94 - Aufzählung zwischenzeitlicher Aktivitäten anlässlich einer längeren Schreibpause

u.a.: Lubber; Dumas;

Ms. Praed. 94 (Ausst. 72) - Summarius in quartum Sententiarum Petri Lombardi

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ausst. 94 - Maria mit der Einhornjagd

Das Blatt stammt aus der Inkunabel Inc. oct. 320 (Ohly/Sack 3003)

Ms.Ff.F.Stoltze 3. 94 - Brief von E. Gottlieb an Friedrich Stoltze

"Zum Himmel sei dein Angesicht gekehrt", "Euch neid' ich nicht, ihr armen Thoren", Frankfurter Latern, Übersetzung von Gedichten in das Elsässische, "Hast du die dreißig Gulde krieht", "Der Dambor un die Bäckermahd"

Der Winter 94/95 in San Remo

Paul Bräuer

Ms. lat. oct. 94 - Psalterium

Vorbesitzer: LOP; Maria Frankhe; Hans Adam von Reisach; Maria von Wobeser (geb. Scherbius)

Über die Organisation der Kaiserlichen Schutztruppe in Deutsch-Ostafrika und die kriegerischen Operationen daselbst während der Jahre 1893/94 : Vortrag

von von Schele

Durch Afrika von Ost nach West : Resultate und Begebenheiten einer Reise von der Deutsch-Ostafrikanischen Küste bis zur Kongomündung in den Jahren 1893/94

von G. A. von Götzen

Adamaua : Bericht über die Expedition des Deutschen Kamerun-Komitees in den Jahren 1893/94

von Siegfried Passarge

Festspiel-Ouverture : für großes Orchester ; op. 94 ; aufgeführt bei Eröffnung des neuen Opernhauses in Frankfurt a/m.

componirt von Georg Goltermann

Die Geschichte Josefs : eine Übersetzung und kritische Behandlung des Midrasch Bereschith rabba : Par. 84, 5 - 22 und Par. 86, 1 - 94,3

Giessen, Univ., Diss., 1897

Stable isotope analysis and temperature reconstruction data from DSDP Hole 94-609B and ODP Hole 162-984B

The Greenland ice sheet is accepted as a key factor controlling the Quaternary glacial scenario. However, the origin and mechanisms of major Arctic glaciation starting at 3.15 Ma and culminating at 2.74 Ma are still controversial. For this phase of intense cooling Ravelo et al. proposed a complex gradual forcing mechanism. In contrast, our new submillennial-scale paleoceanographic records from the Pliocene North Atlantic suggest a far more precise timing and forcing for the initiation of northern hemisphere glaciation (NHG), since it was linked to a 2-3 °C surface water warming during warm stages from 2.95 to 2.82 Ma. These records support previous models, claiming that the final closure of the Panama Isthmus (3.0- ~2.5 Ma induced an increased poleward salt and heat transport. Associated strengthening of North Atlantic Thermohaline Circulation and in turn, an intensified moisture supply to northern high latitudes resulted in the build-up of NHG, finally culminating in the great, irreversible climate crash at marine isotope stage G6 (2.74 Ma). In summary, there was a two-step threshold mechanism that marked the onset of NHG with glacial-to-interglacial cycles quasi-persistent until today.