Retrospective study of salinomycin toxicosis in 66 cats

We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10 cases, motor nerve conductance velocity was mildly decreased in 8/12 cats, and sensory nerve conductance velocity and repetitive nerve stimulation were normal in all examined cases. In five cases the peripheral neuropathy was confirmed by pathohistology. Fluid therapy and supportive care were used as therapy and 52 cats recovered completely. The probability for complete remission was significantly different between mildly and severely affected cases. It seems that the severity of clinical signs and prognosis correlate well with the amount of toxin ingested. We conclude that early recognition and decontamination combined with supportive care results in complete recovery.

[Munchausen syndrome in a 66-year-old patient]

The study of a 66 year old woman's medical chart revealed many discordant elements, leading to the diagnosis of Munchausen's syndrome. The patient had been treated over a period of 20 years at the Medical polyclinic for a variety of symptoms concerning virtually all organs. Her son's chart similarly contains discordant elements, rising the suspicion of a Munchausen Syndrome "by proxy". With this case report, historical aspects and the therapeutic challenge of this syndrome are outlined.

Fluctuation analysis of lung function as a predictor of long-term response to beta2-agonists

The response to beta(2)-agonists differs between asthmatics and has been linked to subsequent adverse events, even death. Possible determinants include beta(2)-adrenoceptor genotype at position 16, lung function and airway hyperresponsiveness. Fluctuation analysis provides a simple parameter alpha measuring the complex correlation properties of day-to-day peak expiratory flow. The present study investigated whether alpha predicts clinical response to beta(2)-agonist treatment, taking into account other conventional predictors. Analysis was performed on previously published twice-daily peak expiratory flow measurements in 66 asthmatic adults over three 6-month randomised order treatment periods: placebo, salbutamol and salmeterol. Multiple linear regression was used to determine the association between alpha during the placebo period and response to treatment (change in the number of days with symptoms), taking into account other predictors namely beta(2)-adrenoceptor genotype, lung function and its variability, and airway hyperresponsiveness. The current authors found that alpha measured during the placebo period considerably improved the prediction of response to salmeterol treatment, taking into account genotype, lung function or its variability, or airway hyperresponsiveness. The present study provides further evidence that response to beta(2)-agonists is related to the time correlation properties of lung function in asthma. The current authors conclude that fluctuation analysis of lung function offers a novel predictor to identify patients who may respond well or poorly to treatment.

Tabellen enthaltend die Zeitangaben für den Beginn der Nacht und des Tages für die Breitengrade + 66 bis -38'' : zum Gebrauch f. d. jüd. Ritus

berechnet u. zsgest. von B. Cohn

Ms. hebr. oct. 66 - Bet ha-beḥirah

Vorbesitzer: Abraham Merzbacher

Ms. Barth. 66 - Homiliar (Sommerteil)

Vorbesitzer: St. Peter Urach; Bartholomaeusstift Frankfurt am Main;

In Börnes Aufsatz: "Juden in Frankfurt a. M." : (Börnes Schriften VI, S. 66 - 70)

L. G.

Evidence for Emergency Vaccination Having Played a Crucial Role to Control the 1965/66 Foot-and-Mouth Disease Outbreak in Switzerland.

Foot-and-mouth disease (FMD) is a highly contagious disease that caused several large outbreaks in Europe in the last century. The last important outbreak in Switzerland took place in 1965/66 and affected more than 900 premises and more than 50,000 animals were slaughtered. Large-scale emergency vaccination of the cattle and pig population has been applied to control the epidemic. In recent years, many studies have used infectious disease models to assess the impact of different disease control measures, including models developed for diseases exotic for the specific region of interest. Often, the absence of real outbreak data makes a validation of such models impossible. This study aimed to evaluate whether a spatial, stochastic simulation model (the Davis Animal Disease Simulation model) can predict the course of a Swiss FMD epidemic based on the available historic input data on population structure, contact rates, epidemiology of the virus, and quality of the vaccine. In addition, the potential outcome of the 1965/66 FMD epidemic without application of vaccination was investigated. Comparing the model outcomes to reality, only the largest 10% of the simulated outbreaks approximated the number of animals being culled. However, the simulation model highly overestimated the number of culled premises. While the outbreak duration could not be well reproduced by the model compared to the 1965/66 epidemic, it was able to accurately estimate the size of the area infected. Without application of vaccination, the model predicted a much higher mean number of culled animals than with vaccination, demonstrating that vaccination was likely crucial in disease control for the Swiss FMD outbreak in 1965/66. The study demonstrated the feasibility to analyze historical outbreak data with modern analytical tools. However, it also confirmed that predicted epidemics from a most carefully parameterized model cannot integrate all eventualities of a real epidemic. Therefore, decision makers need to be aware that infectious disease models are useful tools to support the decision-making process but their results are not equal valuable as real observations and should always be interpreted with caution.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 486 - Zwischenurteil des Instruktionssenats des Königlichen Kammergerichts Berlin zur Schadenersatzklage Caroline Marquet

2 Seiten

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 66 - Darstellung von J. Goullet (geb. Kraus) der schlechten Lebensumstände von Johanna Schopenhauer

u.a.: Hervorhebung der Freundschaft mit Johanna Schopenhauer; Ausflug nach Karlsbad; Vorlesung in Dresden; Bankrott des Bankhauses Muhl in Danzig; Mutter-Sohn-Beziehung; Adele Schopenhauer; Johann Wolfgang von Goethe;

Na 1 Nachlass Max Horkheimer, 26 - Korrespondenzen mit Betty Drury und Fritz Karsen (p. I 13, 280-486)

3 Brief zwischen Gretel Karplus und Max Horkheimer, 10.06.1939, 1939; 8 Briefe zwiachen Liselotte Karplus und Max Horkheimer, 1936-1938; 80 Briefe uns Beilagen sowie Briefwechsel zwischen Betty Drury, Fritz Karsen und Max Horkheimer, 1934-1948; 7 Briefe zwischen Betty Drury und Max Horkheimer, 1938; 4 Briefe zwischen Stephen Duggan vom Institute of International Education, New York, Fritz Karsen und Max Horkheimer, 30.12.1937, 14.02.1938, 24.05.1938; Institute of International Education, New York; 8 Briefe zwischen Oswald Schlockow und Max Horkheimer, 1935-1937; 1 Brief von Max Horkheimer an Katz,... 1940; 2 Briefe zwischen Simon Katzenstein und Max Horkheimer, 04.10.1936, 20.10.1936; 5 Briefe zwischen Thekla Kauffmann 10.12.1938-1939; 4 Briefe und 1 Beilage zwischen Fritz Kaufmann und Max Horkheimer, 1936-1937; 9 Briefe zwischen Rudolf Kayser und Max Horkheimer, 1937-1939; 2 Briefe zwischen Joseph Keil und Max Horkheimer, 21.01.1949, 26.01.1949; 2 Briefe zwischen Werner Kelm und Max Horkheimer, 18.06.1948, 20.06.1948; 1 Brief von Adolf Keller vom World Council of Churches New York an Max Horkheimer; 2 Briefe zwischen Hans Kelsen und Max Horkheimer, 29.02.1936, 26.05.1936; 3 Briefe zwischen Hermann Kesten und Max Horkheimer, 31.01.1947, 1947;

Na 1 Nachlass Max Horkheimer, 66 - Korrespondenzen u.a. mit Ermin Cahn und Max Cahn (p. II 4, 256 - 433)

3 Briefe zwischen Charlotte Bühler und Max Horkheimer, 1946 sowie 4 Papers von Charlotte Bühler zum Antisemitismus; 55 Briefe zwischen Ermin Cahn, Max Cahn und Max Horkheimer, 1941-1949; 1 Brief und Beilage von Max Horkheimer an Max L. Cahn, 1948; 6 Briefe zwischen der Society for the Protection of Science and Learning und Max Horkheimer, 1944-1948; 16 Briefe zwischen Hadley Cantril und Max Horkheimer, 1948-1949 sowie 2 Manuskripte von Hadley Cantril : The Development od a Scientific Morality; Trends of Opinion During World War II; 12 Briefe und Beilage zwischen Charles Carlé und Max Horkheimer, 1942-1943;

Na 1 Nachlass Max Horkheimer, 260 - Korrespondenzen u.a. mit dem Direktor der Stadt- und Unibibliothek Frankfurt am Main Professor Clemens Köttelwesch (p. V 66, 138-320)

2 Briefe zwischen F. Champion Ward und Max Horkheimer, 1967; 1 Brief von Max Horkheimer an John Slawson, 1962; 21 Briefe zwischen dem Direktor der Stadt- und Unibibliothek Frankfurt am Main Professor Clemens Köttelwesch und Max Horkheimer, 1956-; 1 Brief an Hertha Dembitzer, 1974; 1 Brief von Hertha Dembitzer, 1974; Schenkungsbrief 1956; Hertha Dembitzer: 2 Briefe zwischen Hertha Dembitzer und Clemens Köttelwesch, 1974;

Ms. Praed. 66 - Scriptum super quartum Sententiarum

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Fragm. lat. VII 90 - De bello Iudaico (L. VII c. 61 - 66)

Trägerband: Q 16/109; Vorbesitzer: Philippus Jacobus Otto