973 resultados para 44-392A


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A novel erythromycin ribosome methylase gene, erm(44), that confers resistance to macrolide, lincosamide, and streptogramin B (MLSB) antibiotics was identified by whole-genome sequencing of the chromosome of Staphylococcus xylosus isolated from bovine mastitis milk. The erm(44) gene is preceded by a regulatory sequence that encodes two leader peptides responsible for the inducible expression of the methylase gene, as demonstrated by cloning in Staphylococcus aureus. The erm(44) gene is located on a 53-kb putative prophage designated ΦJW4341-pro. The 56 predicted open reading frames of ΦJW4341-pro are structurally organized into the five functional modules found in members of the family Siphoviridae. ΦJW4341-pro is site-specifically integrated into the S. xylosus chromosome, where it is flanked by two perfect 19-bp direct repeats, and exhibits the ability to circularize. The presence of erm(44) in three additional S. xylosus strains suggests that this putative prophage has the potential to disseminate MLSB resistance.

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composée par M. Henkel

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komponiert von L. Lewandowski

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Vorbesitzer: Friedrich Martorf; Philipp Schurg; Johannes Latomus; Bartholomaeusstift Frankfurt am Main

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Welsch (Projektbearbeiter): Zusammenstellung der am 11. Juli 1848 in der Preußischen Nationalversammlung gestellten Anträge und Interpellationen (von insgesamt 23 Abgeordneten)

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Vorbesitzer: Aaron Ben-Moses Fuld;