Docencia pr��ctica en los laboratorios de las ingenier��as de inform��tica apoyada en herramientas CASE.

Aceptado para su publicaci��n en las actas del Segundo Taller de trabajo en Ingenier��a del Software basada en componentes distribuidos ISCDIS��01. En colaboraci��n con VI Jornadas de Ingenier��a de Software y Bases de Datos (Almagro, Ciudad Real - 2 de noviembre de 2001)

C - H ��� 0 and N - H ��� 0 hydrogen bonds in liquid amides investigated by monte carlo simulation

Monte Carlo simulations of liquid formamide, N-methylformamide (MF), and N, N-dimethytformamide (DMF) have been performed in the isothermal and isobaric ensemble at 298 K and 1 atm, aiming to investigate the C-H ��� O and N-H ��� O hydrogen bonds. The interaction energy was calculated using the classical 6-12 Lennard-Jones pairwise potential plus a Coulomb term on a rigid six-site molecular model with the potential parameters being optimized in this work. Theoretical values obtained for heat of vaporization and liquid densities are in good agreement with the experimental data. The radial distribution function [RDF, g(r)] obtained compare well with R-X diffraction data available. The RDF and molecular mechanics (MM2) minimization show that the C-H ��� O interaction has a significant role in the structure of the three liquids. These results are supported by ab initio calculations. This interaction is particularly important in the structure of MF. The intensity of the N - H ��� O hydrogen bond is greater in the MF than formamide. This could explain some anomalous properties verified in MF. �� 1997 John Wiley & Sons, Inc.

Nuclear photoproduction of pseudoscalar mesons at forward angles up to 6.0 GeV

The nuclear incoherent �� 0 photoproduction cross section from 12C is evaluated at forward angles in the 4.0 to 6.0 GeV energy range using the multicollisional intranuclear cascade model MCMC. The model incorporates some improvements in comparison with previous versions associated with the momentum distribution (MD) for light nuclei - extracted from the available (e,e ���p) data - as well as the evaluation of the shadowing effects during the photo-nucleus interaction. The final results of the single and double differential cross sections at forward angles are very sensitive to the MD parameterizations due to the Pauli principle, which largely suppresses the cross sections for low momentum transfer. The attenuation of the nuclear cross section due to pion - nucleus final state interactions is approximately 40% (without nuclear shadowing), which is in nice agreement with the predictions from the Glauber model. The single and double �� 0 differential cross sections are presented for possible applications for the interpretation of the inelastic background in the PrimEx experiment at the Jefferson Laboratory. �� 2007 American Institute of Physics.

Screening the Structural Space of Bicyclo-DNA: Synthesis and Properties of Bicyclo-DNA Functionalized at C(6���)

The synthesis of a novel bicyclo-thymidine nucleoside bearing an ester functionality at C(6') (bc(alpha-alk)-nucleosides) is reported. This nucleoside was incorporated into oligodeoxynucleotides via solid phase phosphoramidite chemistry, and the ester moiety was post-synthetically converted to an amide or a carboxy group, or was left unchanged. Thermal melting data (T-m) with complementary DNA and RNA were collected and compared to natural DNA and to bc- and bc(ox)-DNA. It was found that single incorporations of bc(alpha-alk)-nucleosides in DNA duplexes were destabilizing by 0.5 to 2.5 degrees C/mod, whereas two consecutive bc(alpha-alk)-residues were less destabilizing, and in some cases even stabilizing by 0.5 degrees C/mod. In duplexes with complementary RNA, isolated bc(alpha-alk)-residues destabilized the duplex by -1.0 to -4.0 degrees C/mod, depending on the chemical nature of the substituent, whereas two consecutive modifications were only destabilizing by 0.3-1.0 degrees C/mod. The pairing selectivity was similar to that of unmodified or bc-DNA.

Specifications for bituminous surface dense-graded aggregate type, subclass C-6 (Machine mix) : effective September 1, 1937.

At head of title: ... U.S. Bureau of Public Roads' class C.

Desenvolvimento e avalia����o da acur��cia do sistema de filtra����o (BacFil 6.0) na detec����o de bacilos ��lcool-��cido resistentes em amostras de lavado broncoalveolar de pacientes com suspeita de tuberculose

A baciloscopia �� o principal m��todo diagn��stico da tuberculose (TB) em raz��o do seu baixo custo, rapidez e facilidade de execu����o. Por��m sua sensibilidade �� baixa, principalmente nas formas paucibacilares da doen��a. Nesse sentido, novas metodologias que resultem no aumento da sensibilidade da baciloscopia tornam-se absolutamente necess��rias. Neste estudo, nos propusemos a aprimorar e padronizar o sistema de filtra����o BacFil e avaliar sua performance e acur��cia em amostras paucibacilares (lavado broncoalveolar). Para alcan��ar esses objetivos desenvolvemos o estudo em duas fases. Na primeira fase, foram realizados ensaios para definir: 1) utiliza����o de membranas brancas para visualiza����o de BAAR corados por Auramina-O; 2) aumento do volume de NALC, utiliza����o de p��rolas de vidro no processo de digest��o das amostras e mudan��a no sistema do suporte do pr��-filtro; 3) meios de fixa����o da membrana de filtra����o na l��mina de microscopia; 4) limite de detec����o da t��cnica; 5) aumento do volume de NaOCl e a influ��ncia desse aumento na visualiza����o de BAAR na membrana. Verificou-se que: a membrana de policarbonato branca tem a mesma efici��ncia da membrana de policarbonato preta na visualiza����o de BAAR fluorescentes; o m��todo modificado utilizando maior concentra����o de NALC, p��rolas de vidro e sistema de pr��-filtro baseado em orif��cios obteve 98% de passagem das amostras pelo sistema; a melhor forma de fixa����o da membrana na l��mina foi obtida por interm��dio da utiliza����o de fita dupla face; o limite de detec����o da t��cnica de filtra����o utilizando o sistema BacFil vers��o 6.0 foi de 2 a 9 BAAR por mililitro de suspens��o bacteriana com D.O de 0,250 �� 0,01 a 625nm; o aumento da concentra����o de NaOCl para 10% ajuda na passagem de um maior volume de amostra pelo sistema, por��m ocasiona a diminui����o da quantidade BAAR na membrana de filtra����o ap��s o per��odo necess��rio para todo o processo. Na segunda fase foi avaliado acur��cia da t��cnica padronizada em 101 amostras de lavado broncoalveolar (LBA) de pacientes com suspeita de TB provenientes do Hospital Universit��rio Cassiano Ant��nio de Moraes. Observou-se que a sensibilidade da t��cnica de filtra����o (BacFil vers��o 6.0) foi de 76% e especificidade de 95%. A sensibilidade obtida foi significativamente maior do que a observada na baciloscopia ap��s centrifuga����o que foi de 59% (p = 0,001). No entanto, constatou-se uma diminui����o de especificidade na t��cnica de filtra����o (95%) em rela����o a t��cnica de 8 centrifuga����o (99%). Conclu��mos que as modifica����es realizadas nos sistema de filtra����o permitiu sanar os problemas t��cnicos apresentados nas vers��es anteriores e aumentar a sensibilidade da baciloscopia de amostras paucibacilares (lavado broncoalveolar) para o diagn��stico da TB pulmonar.

Dermite de Contacto �� Mitomicina C. 6 Casos

A Mitomicina C est�� entre uma variedade de agentes quimioterap��uticos intravesicais actualmente dispon��veis para o tratamento do carcinoma superficial da bexiga. Cerca de9% destes doentes desenvolve reac����es adversas cut��neas, geralmente dermites de contacto, localizadas nas m��os, p��s, genitais, ou erup����es mais disseminadas. Descrevem-se 6 casos de dermite de contacto al��rgica �� Mitomicina C, observados entre Junho/2004 e Mar��o/2005,emcinco doentes do sexo masculino e umdo sexo feminino, com uma idade m��dia de 70 anos.

Creaci�� d'un Sistema d'Informaci�� Geogr��fic per a la consulta i gesti�� de la base de v��rtexs geod��sics de Catalunya amb Geomedia PRO 6.0��

L'objectiu ��s realitzar una explicaci�� dels passos i les tasques realitzades per a la construcci�� d'un Sistema d'Informaci�� Geogr��fica (SIG) que permeti la gesti�� de v��rtex geod��sics de Catalunya i la implementaci�� de l'algorisme de Delaunay sobre un conjunt de v��rtex seleccionats.

Iowa Bridge Backwater Software User Manual, Version 2.0, TR-564, 2010

This manual describes how to use the Iowa Bridge Backwater software. It also documents the methods and equations used for the calculations. The main body describes how to use the software and the appendices cover technical aspects. The Bridge Backwater software performs 5 main tasks: Design Discharge Estimation; Stream Rating Curves; Floodway Encroachment; Bridge Backwater; and Bridge Scour. The intent of this program is to provide a simplified method for analysis of bridge backwater for rural structures located in areas with low flood damage potential. The software is written in Microsoft Visual Basic 6.0. It will run under Windows 95 or newer versions (i.e. Windows 98, NT, 2000, XP and later).

S��ntese de beta-N-acetilglicosamin��deos de arila modificados em C-6 como potenciais agentes antimicrobianos

We report herein the synthesis of aryl beta-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents. It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of N-acetylglucosamine in fungi and bacteria. None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), at the concentration of 1 mg/mL in agar diffusion assay.