La clef des grands mystères : suivant Hénoch, Abraham, Hermés Trismégiste, et Salomon /

Mode of access: Internet.

Recueil sur l'Alchimie ; traités de Nicolas FLAMEL, de BERNARD LE TREVISAN, de ZACAIRE, etc.

Contient : « La table d'émeraude, de Hermès trismégiste, père des philosophes », en 13 chapitres ; « La Tourbe des philosophes, ou l'assemblée des disciples de Pitagore, appelée le Code de vérité » ; « Le livre de Nicolas FLAMEL, contenent l'esplication des figures hiéroglifiques qu'il a fait mettre au cimetière des SS. Innocens, à Paris » ; « Le livre de la philosophie naturelle des métaux, de messire BERNARD, comte de la Marche trévisanne » [BERNARD LE TREVISAN] ; autre exemplaire, ms. français 14797, page 70 ; « Opuscule de la philosophie naturelle des métaux, composé par D. ZACHAIRE, gentilhomme de Guyenne » ; même traité que celui qui est contenu dans le ms. français 1089, fol. 2-43, sous le nom de « D. ZECAIRE, philosophe guienoys » ; imprimé en 1574, etc., sous le nom de D. ZACAIRE ; « Traicté du Ciel terrestre, de VENCESLAS LAVINIUS, de Moravie : Il y a un seul esprit corporel que la nature ... » ; « Philalèthe, ou l'entrée ouverte du palais fermé du Roy. Praeface. Je suis un philosophe, qui ne me nommeray point... », en 35 chapitres, suivi (fol. 103 v° ) de « Remarques sur la traduction de Philalèthe » ; cf. mss. français 19955, fol. 1, et 19981, fol. 1 ; « Vente et distribution de remèdes spécifiques à diverses maladies que l'on dit estre incurables », prospectus du « sieur Demours, apoticaire, artiste et botaniste, établi depuis trente ans dans la ville de Marseille » [probablement le possesseur du volume ; son nom se lit dans la marge inférieure des feuillets 9, 16 et 81], s. l. n. d. [après 1715], petit in-4° de 8 pages, imprimé ; « Table ou liste des termes de l'art et des anciens mots qui se trouvent dans les traités de ce volume : Acier des philosophes-vulgaire » ; deux exemplaires, dont le second est incomplet

L'Hermès, journal du magnétisme animale.

Edited by Madame H. Touchard.

A mega-analysis of genome-wide association studies for major depressive disorder

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of recent European ancestry (9240 MDD cases and 9519 controls). In the MDD replication phase, we evaluated 554 SNPs in independent samples (6783 MDD cases and 50 695 controls). We also conducted a cross-disorder meta-analysis using 819 autosomal SNPs with P<0.0001 for either MDD or the Psychiatric GWAS Consortium bipolar disorder (BIP) mega-analysis (9238 MDD cases/8039 controls and 6998 BIP cases/7775 controls). No SNPs achieved genome-wide significance in the MDD discovery phase, the MDD replication phase or in pre-planned secondary analyses (by sex, recurrent MDD, recurrent early-onset MDD, age of onset, pre-pubertal onset MDD or typical-like MDD from a latent class analyses of the MDD criteria). In the MDD-bipolar cross-disorder analysis, 15 SNPs exceeded genome-wide significance (P<5 x 10(-8)), and all were in a 248 kb interval of high LD on 3p21.1 (chr3:52 425 083-53 822 102, minimum P=5.9 x 10(-9) at rs2535629). Although this is the largest genome-wide analysis of MDD yet conducted, its high prevalence means that the sample is still underpowered to detect genetic effects typical for complex traits. Therefore, we were unable to identify robust and replicable findings. We discuss what this means for genetic research for MDD. The 3p21.1 MDD-BIP finding should be interpreted with caution as the most significant SNP did not replicate in MDD samples, and genotyping in independent samples will be needed to resolve its status.

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 +/- 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 +/- 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 +/- 0.06 s.e.), and ADHD and major depressive disorder (0.32 +/- 0.07 s.e.), low between schizophrenia and ASD (0.16 +/- 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Susceptibility variants for male-pattern baldness on chromosome 20p11

We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.

“The new Cagliostro”: Onofroff, Rubén Darío and his story "La esfinge"

The article retraces the career of the famous hypnotist Onofroff and particularly his visit to Buenos Aires, where his activity, in 1895, provoked many discussions and some public embarrassment. In this context Darío, using a pseudonym, published his crónica “La esfinge”. We reproduce “La esfinge”, transcribing the original text of La Nación, with annotations identifying the literary and theosophical sources Darío used when he wrote it.

A genome-wide association study of anorexia nervosa

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(^-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

Cerebrospinal fluid amyloid-beta 1-42 (Aβ1-42) and phosphorylated Tau at position 181 (pTau181) are biomarkers of Alzheimer's disease (AD). We performed an analysis and meta-analysis of genome-wide association study data on Aβ1-42 and pTau181 in AD dementia patients followed by independent replication. An association was found between Aβ1-42 level and a single-nucleotide polymorphism in SUCLG2 (rs62256378) (P = 2.5×10(-12)). An interaction between APOE genotype and rs62256378 was detected (P = 9.5 × 10(-5)), with the strongest effect being observed in APOE-ε4 noncarriers. Clinically, rs62256378 was associated with rate of cognitive decline in AD dementia patients (P = 3.1 × 10(-3)). Functional microglia experiments showed that SUCLG2 was involved in clearance of Aβ1-42.

Mélanges alchimiques.

Contient : « Le chemin aisée (sic) applani pour aller droit à la sacrée citadelle d'Hermès » ; « La Voye unique de la vérité pour faire la médecine des anciens sages » ; « Lettre de Jean Pontanus » ; « Pratique de Jacques Tesson » ; « Manière de faire mon or potable... » ; « Pilules de Jésus-Christ contre la peste ; « Traité d'un ancien manuscrit allemand de Roger Bacon à Guillaume, son frère » ; « Traduction d'un ms. latin, qui a été communiqué à M. de Moloux, du menstrue universel, etc. » ; « Oeuvre de Jean Saunier. » — Etc

Alternatives d'ajuda a alumnes amb dificultats escolars a l'Escola Laietana. 'Alternativas de ayuda para alumnos con dificultades escolares en la Escuela Laietana'.

Describir la historia de la institución Escola Laietana en 7 épocas (de 1963 a 1982). Describir la integración en la escuela de alumnos con dificultades de aprendizaje. Presentar las actividades que se llevan a cabo en el Aula de Integración. La Escola Laietana de Barcelona. Detallar las actividades mediante una descripción subjetiva, de los contenidos tratados en el Aula de Integración: 1) Observación del alumno; 2) Problemas detectados; 3) Horarios; 4) Planteamiento general de estructuras lógico matemáticas, lenguaje y psicomotricidad; 5) Objetivos generales de la intervención en el aula de Integración. Documentos de la institución escolar desde 1963. Se valora positivamente la dinámica del centro, ya que el trabajo en equipo, las discusiones de casos individuales han enriquecido la experiencia educativa de todo el equipo docente. Concluye que el Aula de Integración es necesaria para enriquecer el trabajo en equipo en el centro en cuestión, porque se ha planteado como un reto colectivo para todo el profesorado.