San Juan de Ulúa, ou relation de l'espédition francaise au Mwxique sous les ordes de M. Le Contre Amiral Baudi par M. M. P. Blanchard et A. Dauzats.

UANL

Memorias para la historia de la Guerra de Tejas

UANL

Apuntes para la historia antigua de Coahuila y Texas

UANL

El universo pintorésco, historia de Méjico, Tejas y Guatemala del Sr. Lecainte,

UANL

Recuerdos de la invasión norteamericana 1846-1848

UANL

Verdadera idea de la primera C+E107ampaña de Tejas y sucesos ocurridos después de la acción de San Jacinto

UANL

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.

Induction of the C/EBP homologous protein (CHOP) is considered a key event for endoplasmic reticulum (ER) stress-mediated apoptosis. Type 1 diabetes (T1D) is characterized by an autoimmune destruction of the pancreatic β-cells. Pro-inflammatory cytokines are early mediators of β-cell death in T1D. Cytokines induce ER stress and CHOP overexpression in β-cells, but the role for CHOP overexpression in cytokine-induced β-cell apoptosis remains controversial. We presently observed that CHOP knockdown (KD) prevents cytokine-mediated degradation of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1), thereby decreasing the cleavage of executioner caspases 9 and 3, and apoptosis. Nuclear factor-κB (NF-κB) is a crucial transcription factor regulating β-cell apoptosis and inflammation. CHOP KD resulted in reduced cytokine-induced NF-κB activity and expression of key NF-κB target genes involved in apoptosis and inflammation, including iNOS, FAS, IRF-7, IL-15, CCL5 and CXCL10. This was due to decreased IκB degradation and p65 translocation to the nucleus. The present data suggest that CHOP has a dual role in promoting β-cell death: (1) CHOP directly contributes to cytokine-induced β-cell apoptosis by promoting cytokine-induced mitochondrial pathways of apoptosis; and (2) by supporting the NF-κB activation and subsequent cytokine/chemokine expression, CHOP may contribute to apoptosis and the chemo attraction of mononuclear cells to the islets during insulitis.

Apuntes de la frontera (1891-1892)

UANL

De Barradas á Baudin; un libro de polémica historial

UANL

Role for flagella but not intimin in the persistent infection of the gastrointestinal tissues of specific-pathogen-free chicks by Shiga toxin-negative Escherichia coli O157:H7

Shiga toxin (Stx)-positive Escherichia coli O157:117 readily colonize and persist in specific-pathogen-free (SPF) chicks, and we have shown that an Stx-negative E. coli O157:117 isolate (NCTC12900) readily colonizes SPF chicks for up to 169 days after oral inoculation at 1 day of age. However, the role of intimin in the persistent colonization of poultry remains unclear. Thus, to investigate the role of intimin and flagella, which is a known factor in the persistence of non-O157 E. coli in poultry, isogenic single- and double-intimin and aflagellar mutants were constructed in E. coli O157:117 isolate NCTC12900. These mutants were used to inoculate (10(5) CFU) 1-day-old SPF chicks. In general, significant attenuation of the aflagellate and intiminaflagellate mutants, but not the intimin mutant, was noted at similar time points between 22 and 92 days after inoculation. The intimin-deficient mutant was still being shed at the end of the experiment, which was 211 days after inoculation, 84 days more than the wild type. Shedding of the aflagellar and intimin-aflagellar mutants ceased 99 and 113 days after inoculation, respectively. Histological analysis of gastrointestinal tissues from inoculated birds gave no evidence for true microcolony formation by NCTC12900 or intimin and aflagellar mutants to epithelial cells. However, NCTC12900 mutant derivatives associated with the mucosa were observed as individual cells and/or as large aggregates. Association with luminal contents was also noted. These data suggest that O157 organisms do not require intimin for the persistent colonization of chickens, whereas flagella do play a role in this process.

Política e poder no Estado do Rio de Janeiro na República Velha

o objetivo do presente artigo é analisar a atuação das diversas frações da classe dominante fluminense no período compreendido entre 1889 e 1930, visando o controle do - ou a participação no - poder estadual, bem Como suas propostas políticas e econômicas de reorganização do Estado, e o conteúdo das relações desses grupos com as demais unidades da federação e com o poder central. "A implantação da República federativa no Brasil coincidiu, no Estado do Rio, com sérias dificuldades econômicas e financeiras que, em fins da década de 1890, chegaram a uma situação-limite, muito embora esse quadro de crise tenha sido entremeado por breves conjunturas de recuperação". A elaboração do artigo tem por base o conjunto de trabalhos produzidos pela equipe do Programa de Pesquisa de História do Estado do Rio de Janeiro, do CPDOC/FGV. A equipe do programa é composta pelos pesquisadores Mônica Komis, Paulo Brandi, Renato Lemos, Sérgio Lamarão, Silvia Pantoja, Vera Teixeira da Silva .

A identidade nacional e a formação do espaço-nação na experiência literária da geografia de Dona Benta, de Monteiro Lobato

Pós-graduação em Educação - IBRC

O papel da educação e do Lyceu dirigido pelo Prof. Salathiel de Almeidana configuração do contexto geopolítico, social e econômico de Muzambinho (MG)

Pós-graduação em Educação Matemática - IGCE

Crise monárquica e as experiências de República no município de Franca (1880-1906)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Um painel com cangalhas e bicicletas: os (des)caminhos da modernidade no alto sertão da Bahia (Caetité, 1910-1930)

Pós-graduação em História - FCHS