Les memoires historiques de la Repub. Sequanoise, et des Princes de la Franche-Comté de Bourgougne : auec un sommaire de l'Histoire des Catholiques Rois de Castille, & Portugal, de la maison desdicts Princes de Bourgougne ... /

CCBE S. XVI, G, 1147

Pierre-Antoine-Dominique Della Maria, Brustbild, Profil

Signatur des Originals: S 36/G02945

Antoine Dominique Sauveur Aubert (born 1817), the Artist's Uncle

Paul Cézanne; 2 ft. 7 3/8 in.x 2 ft. 1 15/64 in.; oil on canvas

Antoine Dominique Sauveur Aubert (born 1817), the Artist's Uncle, as a Monk

Paul Cézanne; 2 ft. 1 5/8 in.x 1 ft. 9 1/2 in.; oil on canvas

Histoire des hommes illustres de lordre de Saint Dominique... /

Mode of access: Internet.

Histoire des hommes illustres de lordre de Saint Dominique... /

Mode of access: Internet.

Histoire des hommes illustres de l'Ordre de Saint Dominique... /

Mode of access: Internet.

Histoire des hommes illustres de l'Ordre de Saint Dominique... /

Mode of access: Internet.

Histoire des hommes illustres de l'Ordre de Saint Dominique... /

Contiene además con port. propia y fecha de 1748: Discours de Notre Très-Saint Pere le Pape Benoit XIV sur la mort précieuse de Pierre Martyr, religieux de l'Ordre de Saint Dominique...

Histoire des hommes illustres de l'Ordre de Saint Dominique ... /

Mode of access: Internet.

Histoire de Portugal : contenant les enterprises, navigations, & gestes memorables des Portugallois, tant en la cõqueste des Indes Orientales par eux descouvertes, qu'és guerres d'Afrique & autres exploits, depuis l'an mil quatre cens nonãte six, jusques à l'an mil cinq cens septante huit, sous Emmanuel premier, Jean troisieme, & Sebastian premier du nom / Pour Antoine Chuppin, ed. ; comprinse en vingt livres, dont les douze premiers sont traduits du latin de Ierosme Osorius, Euesque de Sylues en Algarve, les huit suivans prins de Lopez de Castagnede & d'autres historiensNouvellement mise en françois, par S.G.S. avec un discours du fruit qu'on peut recueillir de la lecture de cette histoire, & ample indice des matieres principales y contenues

Contém os empreendimentos, as navegações e os gestos memoráveis dos portugueses, inclusive em suas colônias.

Clinical staging versus laparotomy and combined modality with MOPP versus ABVD in early-stage hodgkin's disease: the H6 twin randomized trials from the european organization for research and treatment of cancer lymphoma cooperative group

info:eu-repo/semantics/published

Bordetella pertussis from functional genomics to intranasal vaccination.

Whooping cough still represents a major health problem, despite the use of effective vaccines for several decades. Being classically a typical childhood disease, whooping cough in young adults is now more common than it used to be, suggesting that protection after vaccination wanes during adolescence. As an alternative to the current vaccines, we wish to develop live attenuated vaccines to be delivered by the nasal route, such as to mimic the natural route of infection and to induce long lasting immunity. Bordetella pertussis, the etiological agent of whooping cough, produces a number of virulence factors, including toxins. Its recently determined genome sequence makes it now possible to apply functional genomics, such as transcriptomics and systematic knock-out mutagenesis. The expression of most known B. pertussis virulence genes is controlled by the two-component system BvgA/S. DNA microarray analyses have led to the identification of novel genes in the BvgA/S regulon, some of which are activated by BvgA/S and others are repressed by BvgA/S. In addition, some genes appear to be differentially modulated by nicotinic acid and MgSO4, both known to modulate the expression of BvgA/S-regulated genes. Among others, the functional genomics approach has uncovered two strongly BvgA/S-activated genes, named hotA and hotB (for 'homolog of toxin'), the products of which show high sequence similarities to pertussis toxin subunits. The identification of the full array of virulence factors, as well as an integrated understanding of the bacterial physiology should allow us to design attenuated B. pertussis strains useful for intranasal vaccination. A first generation of attenuated strains has already shown full protection in mice after a single intranasal administration. Such strains may also serve as vaccine carriers for heterologous antigens, in order to vaccinate against several different pathogens simultaneously.