Multiobjective linear model for pre-feasibility design of cogeneration systems

This article deals with some methodologies for economic and technical evaluations of cogeneration projects proposed by several authors. A discussion on design philosophy applied to thermal power plants leads to the decision problem of a conflicting, multiobjective formulation that includes the most important parameters. This model is formulated to help decision makers and designers in choosing compromise values for included parameters. (C) 1997 Elsevier B.V. Ltd.

Caribbean enterprise for the production and distribution of printed and audio-visual materials: a pre-feasibility study

Includes bibliography

Pre-Feasibility Study of Hybrid Wind Power-H-2 System Connected to Electrical Grid

The growth of wind power as an electric energy source is profitable from an environmental point of view and improves the energetic independence of countries with little fossil fuel resources. However, the wind resource randomness poses a great challenge in the management of electric grids. This study raises the possibility of using hydrogen as a mean to damp the variability of the wind resource. Thus, it is proposed the use of all the energy produced by a typical wind farm for hydrogen generation, that will in turn be used after for suitable generation of electric energy according to the operation rules in a liberalized electric market.

Estudio de pre-factibilidad para ampliar la planta de lácteos de la Cooperativa Coagroles en Sesquilé, Cundinamarca

El estudio de pre-factibilidad para ampliar la planta de lácteos de la cooperativa Coagroles en el municipio de Sesquilé, ubicado en Cundinamarca, surgió con el fin de aportar a los miembros de la cooperativa desde una punto de vista académico, cómo pueden tener un mejor desempeño en las labores para que el funcionamiento de la Cooperativa sea exitoso. Al notar que los asociados de Coagroles han mostrado el interés por este proyecto, nosotros como estudiantes de Administración de Negocios Internacionales y Administración en Logística y Producción, hemos puesto nuestros conocimientos a una investigación, donde se han analizado tanto fortalezas como debilidades con el fin de encontrar alternativas y opciones para mejorar la situación actual como es la producción y enfriamiento de la leche. Teniendo como objetivo el incremento en los ingresos económicos de la cooperativa Coagroles. Este es un trabajo realizado en alianza con una entidad educativa, en este caso Universidad del Rosario y entidades del Gobierno, donde juntos son los encargados del desarrollo integrar de todo el país. Busca brindar a la ciudadanía oportunidades de mejora y progreso en las actividades económicas que realizan. Actualmente, se vive una situación de complejidad en los mercados, donde cada día son más exigentes, teniendo en cuenta que los pequeños productores deben ir fortaleciéndose para competir con otras entidades no solo a nivel nacional sino próximamente a nivel internacional.

Estudio de pre factibilidad para el montaje de un tanque de enfriamiento de leche en el municipio de Machetá, Cundinamarca

Este proyecto hace parte del Convenio suscrito entre El Colegio Mayor de Nuestra Señora del Rosario y la Gobernación de Cundinamarca, para adelantar el proyecto de “Municipio Saludables como Polo de Desarrollo Local (MSPDL)”, cuyo objetivo general es mejorar la calidad de vida de los habitantes de tres (3) municipios escogidos por la Gobernación de Cundinamarca: Mesitas de El Colegio, ubicado en la Provincia del Tequendama, Sesquilé y Machetá, ubicados en la Provincia de Almeidas. En el desarrollo del proyecto la Facultad de Administración de la Universidad del Rosario encontró en el municipio de Machetà, la Asociación “Vuestra Honrosa Labranza, asociación, formada por miembros de tres (3) veredas en el municipio. En las visitas realizadas al municipio y en las charlas sostenidas con algunos de los socios, manifestaron interés por la implementación del proyecto en su asociación. En reuniones y conversaciones sostenidas con el Secretario de Desarrollo Social de la Gobernación de Cundinamarca, en los que se han presentado varios informes de avance del proyecto Municipio Saludable como Polo de Desarrollo Local (MSPDL), se comentó explícitamente la problemática planteada por la Asociación Vuestra Honrosa Labranza”, con el fin de conseguir una forma para apoyarlos, con el montaje de un tanque de enfriamiento de leche. Para el desarrollo del estudio de Pre factibilidad del montaje de un tanque para el enfriamiento de la leche, se desarrollaran los capítulos de mercado, técnico, administrativo, legal, ambiental y financiero, con el fin de evaluar si esta información es suficiente y decidir si la idea del proyecto es viable o no.

Providing energy efficiency location-based strategies for buildings using linked open data

Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.

Prefactibilidad de producción y comercialización de quesos en Machetá

Con el objetivo de incrementar los ingresos de los pequeños ganaderos de Machetá, se realizó un análisis de prefactibilidad de la venta y comercialización de queso mediante la cooperativa "Vuestra Honrosa Labranza". En un trabajo conjunto con los miembros de la cooperativa se desarrolló un plan de negocio basado en la producción de leche agregada de estos pequeños ganaderos. Este estudio de pre factibilidad surge como respuesta a la problemática que genera el hecho de que en Colombia una gran parte de la población vive con escasos recursos y aparentemente las posibilidades de salir de este estado son pocas, este es el caso de los productores de leche de Machetá, que pese a tener experiencia en esta actividad se han visto en desventaja debido a la falta de capacitación y de oportunidades para obtener un producto final competitivo.

Proyecto de prefactibilidad para un plan de negocios en la diversificación de productos de la panela en una finca productora de caña de azúcar

Estudiar la viabilidad dentro de un alcance de pre-factibilidad la diversificación de productos de origen de la caña de azúcar para el mercado colombiano y posibles mercados de exportación, principalmente hacia países con que se han firmado tratados de libre comercio, a través del desarrollo de un Plan de Negocio, que permita la evaluación de alternativas que facilite la toma de decisiones tanto para los inversionistas actuales respecto al presente y futuro de la explotación agrícola de la finca, en este renglón de tradición en la zona.

Renewable energies potential in Jamaica

Includes bibliography

Intracranial Nimodipine Implant: Feasibility and Implications for the Treatment of Subarachnoid Hemorrhage – A Pre-Clinical Study

Intracranial aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition requiring immediate neurocritical care. A ruptured aneurysm must be isolated from arterial circulation to prevent rebleeding. Open surgical clipping of the neck of the aneurysm or intra-arterial filling of the aneurysm sack with platinum coils are major treatment strategies in an acute phase. About 40% of the patients suffering from aSAH die within a year of the bleeding despite the intensive treatment. After aSAH, the patient may develop a serious complication called vasospasm. Major risk for the vasospasm takes place at days 5–14 after the primary bleeding. In vasospasm, cerebral arteries contract uncontrollably causing brain ischemia that may lead to death. Nimodipine (NDP) is used to treat of vasospasm and it is administrated intravenously or orally every four hours for 21 days. NDP treatment has been scientifically proven to improve patients’ clinical outcome. The therapeutic effect of L-type calcium channel blocker NDP is due to the ability to dilate cerebral arteries. In addition to vasodilatation, recent research has shown the pleiotropic effect of NDP such as inhibition of neuronal apoptosis and inhibition of microthrombi formation. Indeed, NDP inhibits cortical spreading ischemia. Knowledge of the pathophysiology of the vasospasm has evolved in recent years to a complex entity of early brain injury, secondary injuries and cortical spreading ischemia, instead of being pure intracranial vessel spasm. High NDP levels are beneficial since they protect neurons and inhibit the cortical spreading ischemia. One of the drawbacks of the intravenous or oral administration of NPD is systemic hypotension, which is harmful particularly when the brain is injured. Maximizing the beneficial effects and avoiding systemic hypotension of NDP, we developed a sustained release biodegradable NDP implant that was surgically positioned in the basal cistern of animal models (dog and pig). Higher concentrations were achieved locally and lower concentrations systemically. Using this treatment approach in humans, it may be possible to reduce incidence of harmful hypotension and potentiate beneficial effects of NDP on neurons. Intracellular calcium regulation has a pivotal role in brain plasticity. NDP blocks L-type calcium channels in neurons, substantially decreasing intracellular calcium levels. Thus, we were interested in how NDP affects brain plasticity and tested the hypothesis in a mouse model. We found that NDP activates Brain-derived neurotrophic factor (BDNF) receptor TrkB and its downstream signaling in a reminiscent of antidepressant drugs. In contrast to antidepressant drugs, NDP activates Akt, a major survival-promoting factor. Our group’s previous findings demonstrate that long-term antidepressant treatment reactivates developmental-type of plasticity mechanisms in the adult brain, which allows the remodeling of neuronal networks if combined with appropriate rehabilitation. It seems that NDP has antidepressant-like properties and it is able to induce neuronal plasticity. In general, drug induced neuronal plasticity has a huge potential in neurorehabilitation and more studies are warranted.

Proposed feasibility oversight for pre-pack administration in England and Wales: window dressing or effective reform?

The 2014 Graham proposals aimed at reducing recidivism are unlikely to achieve the desired goals. It is argued that due consideration must be had for the future of the rescued entity. Further, both the viability review and the proposed capital structure of the rescued entity must be carefully assessed.

Prevention of hypertension in patients with pre-hypertension: protocol for the PREVER-prevention trial

Background: Blood pressure (BP) within pre-hypertensive levels confers higher cardiovascular risk and is an intermediate stage for full hypertension, which develops in an annual rate of 7 out of 100 individuals with 40 to 50 years of age. Non-drug interventions to prevent hypertension have had low effectiveness. In individuals with previous cardiovascular disease or diabetes, the use of BP-lowering agents reduces the incidence of major cardiovascular events. In the absence of higher baseline risk, the use of BP agents reduces the incidence of hypertension. The PREVER-prevention trial aims to investigate the efficacy, safety and feasibility of a population-based intervention to prevent the incidence of hypertension and the development of target-organ damage. Methods: This is a randomized, double-blind, placebo-controlled clinical trial, with participants aged 30 to 70 years, with pre-hypertension. The trial arms will be chlorthalidone 12.5 mg plus amiloride 2.5 mg or identical placebo. The primary outcomes will be the incidence of hypertension, adverse events and development or worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart failure, evidence of new sub-clinical atherosclerosis, and sudden death. The study will last 18 months. The sample size was calculated on the basis of an incidence of hypertension of 14% in the control group, a size effect of 40%, power of 85% and P alpha of 5%, resulting in 625 participants per group. The project was approved by the Ethics committee of each participating institution. Discussion: The early use of blood pressure-lowering drugs, particularly diuretics, which act on the main mechanism of blood pressure rising with age, may prevent cardiovascular events and the incidence of hypertension in individuals with hypertension. If this intervention shows to be effective and safe in a population-based perspective, it could be the basis for an innovative public health program to prevent hypertension in Brazil.

Feasibility and acceptability of an exergame intervention for schizophrenia

Objectives To evaluate the feasibility and acceptability of an exergame intervention as a tool to promote physical activity in outpatients with schizophrenia. Design Feasibility/Acceptability Study and Quasi-Experimental Trial. Method Sixteen outpatients with schizophrenia received treatment as usual and they all completed an 8-week exergame intervention using Microsoft Kinect® (20 min sessions, biweekly). Participants completed pre and post treatment assessments regarding functional mobility (Timed Up and Go Test), functional fitness performance (Senior Fitness Test), motor neurological soft signs (Brief Motor Scale), hand grip strength (digital dynamometer), static balance (force plate), speed of processing (Trail Making Test), schizophrenia-related symptoms (Positive and Negative Syndrome Scale) and functioning (Personal and Social Performance Scale). The EG group completed an acceptability questionnaire after the intervention. Results Attrition rate was 18.75% and 69.23% of the participants completed the intervention within the proposed schedule. Baseline clinical traits were not related to game performance indicators. Over 90% of the participants rated the intervention as satisfactory and interactive. Most participants (76.9%) agreed that this intervention promotes healthier lifestyles and is an acceptable alternative to perform physical activity. Repeated-measures MANOVA analyses found no significant multivariate effects for combined outcomes. Conclusion This study established the feasibility and acceptability of an exergame intervention for outpatients with schizophrenia. The intervention proved to be an appealing alternative to physical activity. Future trials should include larger sample sizes, explore patients' adherence to home-based exergames and consider greater intervention dosage (length, session duration, and/or frequency) in order to achieve potential effects.