896 resultados para May <Familie : 14.-21. Jh. : Bern>May <Familie : 14.-21. Jh. : Bern>


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Bibliography : p. 144-148.

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The speech is a response by Hon. James H. Hammond as to whether or not the territorial governments established by Congress have the power to define and declare what shall be and what shall not be property within the territorial boundaries. The speech goes on to discuss colonists who went to newly purchased territory and claimed land as their own. He argues whether or not these people have sovereignty of the land over the government.

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Background: Prognosis of prostate cancer (PCa) is based mainly in histological aspects together with PSA serum levels that not always reflect the real aggressive potential of the neoplasia. The micro RNA (miRNA) mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase (MMP) inhibitor RECK. Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line. Materials and methods: To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21. To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction (qRT-PCR). Results: The in vitro assays showed a decrease in expression levels of RECK after transfection with pre-miR-21, and an increase of MMP9 that is regulated by RECK compared to PCa cells treated with anti-miR-21. We defined three profiles to compare the prognostic factors. The first was characterized by miR-21 and RECK underexpression (N = 25) the second was characterized by miR-21 overexpression and RECK underexpression (N = 12), and the third was characterized by miR-21 underexpression and RECK overexpression (N = 16). From men who presented the second profile (miR-21 overexpression and RECK underexpression) 91.7% were staged pT3. For the other two groups 48.0%, and 46.7% of patients were staged pT3 (p = 0.025). Conclusions: Our results demonstrate RECK as a target of miR-21. We believe that miR-21 may be important in PCa progression through its regulation of RECK, a known regulator of tumor cell invasion.

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37 Briefe zwischen Fritz Rabinowitsch, Gregor Rabinowitsch, Fred Roberts und Max Horkheimer, 1936-1943; 14 Briefe und Beilagen zwischen Finley Parker, Benjamin Parker und dem American General Consulat, 1937-1939; 4 Brief zwischen dem National Council of Jewish Women New York und Max Horkheimer, 1937; 31 Briefe und Beilagen zwischen Finley Parker, Benjamin Parker und Max Horkheimer, 1937-1939; 7 Briefe zwischen Franz L. Neumann und Finley Parker, Benjamin Parker, 09.10.1937, 1937; 2 Briefe zwischen dem American Conulat, General und dem National Council of Jewish Women, 27.07.1937, 16.08.1937; 1 Brief von Finley und Benjamin Parker an Gregor Rabinowitsch, 22.10.1937; 3 Briefe von Max Horkheimer an das United States Consulate Berlin, 1937; 1 Brief von Finley und Benjamin Parker an Hans-Heinrich Schulz, 21.09.1937; 1 Brief von Finley und Benjamin Parker an Eberhard Roethe, 21.09.1937; 6 Briefe zwischen Friedrich Pollock und Max Horkheimer, 1937-1943; 2 Briefe zwischen dem Schweizerischer Buchhändlerverein und Max Horkheimer, 31.07.1937, 10.09.1937; 2 Briefe zwischen Robert Hilb und Max Horkheimer, 07.09.1937; 2 Briefe zwischen Franz Neumann und Max Horkheimer, 29.08.1937, 31.08.1937; 11 Briefe zwischen Alexander Farquharson und Max Horkheimer, 1937; 1 Brief von Girsberger an Max Horkheimer, 29.08.1937; 1 Brief von Abner J. Rubien an Max Horkheimer, 29.07.1937; 1 Brief von Brill an Max Horkheimer, 29.07.1937; 2 Briefe zwischen Otto Nathan und Max Horkheimer, 28.07.1937, 25.04.1939; 5 Briefe zwischen dem Germany Emergency Committee London und Max Horkheimer, 1937; 2 Briefe von der National City Bank New York an das American Consul, New York, 1937; 1 Brief von John G. Jenkins an Paul F. Lazarsfeld, 05.04.1937; 3 Briefe zwischen Frank H. Bowles und Max Horkheimer, 23.03.1937, 1937;