El recurso de la paradoja en la Farsalia de Lucano

En el presente trabajo analizaremos algunas paradojas de la Farsalia, que ejemplifican la presencia de esta figura en una amplia diversidad de ámbitos (genérico, lingüístico, político, mítico - religioso y moral) y asimismo muestran su posición nuclear en el funcionamiento de la estructura semántica y formal de la epopeya. Los trabajos de F. Ahl (1976), W. Johnson (1987), A. Perutelli (2000), E. Narducci (2002) y S. Bartsch (1997; 2005) constituyen los principales referentes bibliográficos en su consideración de la importancia del empleo de la paradoja en la Farsalia

¿Fue Ovidio un poeta latino de la Edad de Plata?

Este artículo busca establecer cómo las características más sobresalientes de las Metamorfosis de Ovidio, consideradas por muchos estudiosos como el modelo por excelencia de los poetas latinos del siglo I d.C. no resultan tan influyentes en la praxis poética de los autores neronianos y flavianos. Aun considerando los numerosos paralelismos formales y estilísticos existentes en estos autores, tal como el uso de la paradoja, la sobreexplicitación visual y la acumulación de detalles, resulta claro que el propósito y el uso de los diferentes topoi literarios que estos poetas hacen son completamente distintos. Un análisis de los motivos de la nekya y la tempestad en Ovidio, Lucano, Silio Itálico, Valerio Flaco y Estacio muestra cuánto más a menudo los poetas latinos del siglo I d.C. recurren a la obra de Virgilio que a la de Ovidio

El recurso de la paradoja en la Farsalia de Lucano

En el presente trabajo analizaremos algunas paradojas de la Farsalia, que ejemplifican la presencia de esta figura en una amplia diversidad de ámbitos (genérico, lingüístico, político, mítico - religioso y moral) y asimismo muestran su posición nuclear en el funcionamiento de la estructura semántica y formal de la epopeya. Los trabajos de F. Ahl (1976), W. Johnson (1987), A. Perutelli (2000), E. Narducci (2002) y S. Bartsch (1997; 2005) constituyen los principales referentes bibliográficos en su consideración de la importancia del empleo de la paradoja en la Farsalia

¿Fue Ovidio un poeta latino de la Edad de Plata?

Este artículo busca establecer cómo las características más sobresalientes de las Metamorfosis de Ovidio, consideradas por muchos estudiosos como el modelo por excelencia de los poetas latinos del siglo I d.C. no resultan tan influyentes en la praxis poética de los autores neronianos y flavianos. Aun considerando los numerosos paralelismos formales y estilísticos existentes en estos autores, tal como el uso de la paradoja, la sobreexplicitación visual y la acumulación de detalles, resulta claro que el propósito y el uso de los diferentes topoi literarios que estos poetas hacen son completamente distintos. Un análisis de los motivos de la nekya y la tempestad en Ovidio, Lucano, Silio Itálico, Valerio Flaco y Estacio muestra cuánto más a menudo los poetas latinos del siglo I d.C. recurren a la obra de Virgilio que a la de Ovidio

El recurso de la paradoja en la Farsalia de Lucano

En el presente trabajo analizaremos algunas paradojas de la Farsalia, que ejemplifican la presencia de esta figura en una amplia diversidad de ámbitos (genérico, lingüístico, político, mítico - religioso y moral) y asimismo muestran su posición nuclear en el funcionamiento de la estructura semántica y formal de la epopeya. Los trabajos de F. Ahl (1976), W. Johnson (1987), A. Perutelli (2000), E. Narducci (2002) y S. Bartsch (1997; 2005) constituyen los principales referentes bibliográficos en su consideración de la importancia del empleo de la paradoja en la Farsalia

¿Fue Ovidio un poeta latino de la Edad de Plata?

Este artículo busca establecer cómo las características más sobresalientes de las Metamorfosis de Ovidio, consideradas por muchos estudiosos como el modelo por excelencia de los poetas latinos del siglo I d.C. no resultan tan influyentes en la praxis poética de los autores neronianos y flavianos. Aun considerando los numerosos paralelismos formales y estilísticos existentes en estos autores, tal como el uso de la paradoja, la sobreexplicitación visual y la acumulación de detalles, resulta claro que el propósito y el uso de los diferentes topoi literarios que estos poetas hacen son completamente distintos. Un análisis de los motivos de la nekya y la tempestad en Ovidio, Lucano, Silio Itálico, Valerio Flaco y Estacio muestra cuánto más a menudo los poetas latinos del siglo I d.C. recurren a la obra de Virgilio que a la de Ovidio

Mucopolysaccharidosis Type Ii: Identification Of 30 Novel Mutations Among Latin American Patients.

In this study, 103 unrelated South-American patients with mucopolysaccharidosis type II (MPS II) were investigated aiming at the identification of iduronate-2-sulfatase (IDS) disease causing mutations and the possibility of some insights on the genotype-phenotype correlation The strategy used for genotyping involved the identification of the previously reported inversion/disruption of the IDS gene by PCR and screening for other mutations by PCR/SSCP. The exons with altered mobility on SSCP were sequenced, as well as all the exons of patients with no SSCP alteration. By using this strategy, we were able to find the pathogenic mutation in all patients. Alterations such as inversion/disruption and partial/total deletions of the IDS gene were found in 20/103 (19%) patients. Small insertions/deletions/indels (<22 bp) and point mutations were identified in 83/103 (88%) patients, including 30 novel mutations; except for a higher frequency of small duplications in relation to small deletions, the frequencies of major and minor alterations found in our sample are in accordance with those described in the literature.

Musculoskeletal Evaluation In Severe Haemophilia A Patients From Latin America.

There is a paucity of literature on haemophilia treatment in Latin American countries, a region characterized by rapidly improving systems of care, but with substantial disparities in treatment between countries. The aim of this study was to evaluate the musculoskeletal status of haemophilia patients from Latin America and to examine the relationship between musculoskeletal status and treatment practices across countries. The Committee of Latin America on the Therapeutics of Inhibitor Groups conducted a survey of its member country representatives on key aspects of haemophilia treatment in 10 countries. Musculoskeletal status of patients was obtained during routine comprehensive evaluations between March 2009 and March 2011. Eligible patients had severe haemophilia A (factor VIII <1%) without inhibitors (<0.6 BU mL(-1) ) and were ≥5 years of age. Musculoskeletal status was compared between three groups of countries, based primarily on differences in the availability of long-term prophylaxis. Overall, 143 patients (5-66 years of age) were enrolled from nine countries. In countries where long-term prophylaxis had been available for at least 10 years (Group A), patients aged 5-10 years had significantly better mean World Federation of Hemophilia clinical scores, fewer target joints and fewer affected joints than patients from countries where long-term prophylaxis has been available for about 5 years (Group B) or was not available (Group C). In Latin America, the musculoskeletal status of patients with severe haemophilia without inhibitors has improved significantly in association with the provision of long-term prophylaxis. As more countries in Latin America institute this practice, further improvements are anticipated.

Is Misión Milagro an effective program to prevent blindness in Latin America?

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Rates of antimicrobial resistance in latin america (2004-2007) and in vitro activity of the glycylcycline tigecycline and of other antibiotics

As a part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.), Gram-positive and Gram-negative bacterial isolates were collected from 33 centers in Latin America (centers in Argentina, Brazil, Chile, Colombia, Guatemala, Honduras, Jamaica, Mexico, Panama, Puerto Rico, and Venezuela) from January 2004 to September 2007. Argentina and Mexico were the greatest contributors of isolates to this study. Susceptibilities were determined according to Clinical Laboratory Standards Institute guidelines. Resistance levels were high for most key organisms across Latin America: 48.3% of Staphylococcus aureus isolates were methicillin-resistant while 21.4% of Acinetobacter spp. isolates were imipenem-resistant. Extended-spectrum β-lactamase were reported in 36.7% of Klebsiella pneumoniae and 20.8% of E. coli isolates. Tigecycline was the most active agent against Gram-positive isolates. Tigecycline was also highly active against all Gram-negative organisms, with the exception of Pseuodomonas aeruginosa, against which piperacillin-tazobactam was the most active agent tested (79.3% of isolates susceptible). The in vitro activity of tigecycline against both Gram-positive and Gram-negative isolates indicates that it may be an useful tool for the treatment of nosocomial infections, even those caused by organisms that are resistant to other antibacterial agents.

Clinical outcomes of long-acting injectable risperidone in patients with schizophrenia: six-month follow-up from the Electronic Schizophrenia Treatment Adherence Registry in Latin America

Background: Risperidone long-acting injection (RLAI) has been shown to be efficacious, improve compliance, and increase long-term retention rate on therapy. The aim of this work was to determine the effect of RLAI on clinical outcome and hospitalization rate in patients with schizophrenia or schizoaffective disorder enrolled in the electronic Schizophrenia Treatment Adherence Registry in Latin America. Methods: Data were collected at baseline, retrospectively for the 12 months prior to baseline, and prospectively every three months for 24 months. Hospitalization prior to therapy was assessed by a retrospective chart review. Efficacy and functioning were evaluated using Clinical Global Impression of Illness Severity (CGI-S), Personal and Social Performance (PSP), and Global Assessment of Functioning (GAF) scores. Relapse and treatment were also registered. Results: Patients were recruited in Mexico (n = 53), Brazil (n = 11), and Colombia (n = 15). Sixty-five percent (n = 52) were male, and mean age was 32.9 years. Patients were classified as having schizophrenia (n = 73) or schizoaffective disorder (n = 6). The mean dose of RLAI at six months was 34.1 mg (standard deviation = 10.2 mg). The percentage of hospitalized patients before treatment was 28.2% and 5.1% at six months after initiating RLAI (P < 0.001). Significant changes were registered on CGI-S, GAF, and PSP scores. Conclusions: RLAI was associated with an improvement in clinical symptoms and functioning, and a greater reduction in hospitalization.

Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study

Background Associations between aplastic anemia and numerous drugs, pesticides and chemicals have been reported. However, at least 50% of the etiology of aplastic anemia remains unexplained. Design and Methods This was a case-control, multicenter, multinational study, designed to identify risk factors for agranulocytosis and aplastic anemia. The cases were patients with diagnosis of aplastic anemia confirmed through biopsy or bone marrow aspiration, selected through an active search of clinical laboratories, hematology clinics and medical records. The controls did not have either aplastic anemia or chronic diseases. A total of 224 patients with aplastic anemia were included in the study, each case was paired with four controls, according to sex, age group, and hospital where the case was first seen. Information was collected on demographic data, medical history, laboratory tests, medications, and other potential risk factors prior to diagnosis. Results The incidence of aplastic anemia was 1.6 cases per million per year. Higher rates of benzene exposure (>= 30 exposures per year) were associated with a greater risk of aplastic anemia (odds ratio, OR: 4.2; 95% confidence interval, CI: 1.82-9.82). Individuals exposed to chloramphenicol in the previous year had an adjusted OR for aplastic anemia of 8.7 (CI: 0.87-87.93) and those exposed to azithromycin had an adjusted OR of 11.02 (CI 1.14-108.02). Conclusions The incidence of aplastic anemia in Latin America countries is low. Although the research study centers had a high coverage of health services, the underreporting of cases of aplastic anemia in selected regions can be discussed. Frequent exposure to benzene-based products increases the risk for aplastic anemia. Few associations with specific drugs were found, and it is likely that some of these were due to chance alone.

Latin American Consensus: Children Born Small for Gestational Age

Background: Children born small for gestational age (SGA) experience higher rates of morbidity and mortality than those born appropriate for gestational age. In Latin America, identification and optimal management of children born SGA is a critical issue. Leading experts in pediatric endocrinology throughout Latin America established working groups in order to discuss key challenges regarding the evaluation and management of children born SGA and ultimately develop a consensus statement. Discussion: SGA is defined as a birth weight and/or birth length greater than 2 standard deviations (SD) below the population reference mean for gestational age. SGA refers to body size and implies length-weight reference data in a geographical population whose ethnicity is known and specific to this group. Ideally, each country/region within Latin America should establish its own standards and make relevant updates. SGA children should be evaluated with standardized measures by trained personnel every 3 months during year 1 and every 6 months during year 2. Those without catch-up growth within the first 6 months of life need further evaluation, as do children whose weight is <= -2 SD at age 2 years. Growth hormone treatment can begin in SGA children > 2 years with short stature (< -2.0 SD) and a growth velocity < 25th percentile for their age, and should continue until final height (a growth velocity below 2 cm/year or a bone age of > 14 years for girls and > 16 years for boys) is reached. Blood glucose, thyroid function, HbA1c, and insulin-like growth factor-1 (IGF-1) should be monitored once a year. Monitoring insulin changes from baseline and surrogates of insulin sensitivity is essential. Reduced fetal growth followed by excessive postnatal catch-up in height, and particularly in weight, should be closely monitored. In both sexes, gonadal function should be monitored especially during puberty. Summary: Children born SGA should be carefully followed by a multidisciplinary group that includes perinatologists, pediatricians, nutritionists, and pediatric endocrinologists since 10% to 15% will continue to have weight and height deficiency through development and may benefit from growth hormone treatment. Standards/guidelines should be developed on a country/region basis throughout Latin America.