999 resultados para Københavns universitet. Botanisk have


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no. 104

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no. 101-114

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no. 73-75

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no. 93-100

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Mode of access: Internet.

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Pritzel (2nd ed.)

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With Nov. 1902 are bound: Høffding, H. Om nogle religionsfilosofiske arbejder fra den nyeste tid. 1903; Copenhagen. Universitet. Indbydelsesskrift til Kjøovenhavns universitets aarsfest til erindring om kirkens reformation, nov. 1903. 1903.

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In cancer, a subpopulation of malignant cells expresses markers of normal stem cells. These cells have the potential of initiating tumor growth and therefore also tumor recurrence. Thus, these cells are called cancer stem cells. A myriad of markers have been applied to identify these cells, but no single marker can be found exclusively in cancer stem cells. In many types of cancer, clinical recurrence and tumor progression are the main causes of mortality, despite intense oncological treatment. It has been proposed that the presence of cancer stem cells causes this resistance to therapy. The scope of this thesis is to investigate the role of stem cell markers and genes in the clinical setting. Especially, the aim was to elucidate the clinical significance of stem cell markers as novel prognostic and diagnostic tools in cancer. Tumor biopsy material from central nervous system tumors (oligodendroglioma, astrocytoma and glioblatoma), neural crest derived tumors (pheochromocytomas) and oral carcinoma was screened for stem cell markers. Initially, 15 stem cell markers were screened in a test series of gliomas. The markers applied for expanded tumor analyses (in 305 cases of glioma, 42 cases of pheochromocytoma, and 73 cases of oral carcinoma) were BMI-1, Snail, p16, mdm2, and c-Myc. Data on marker expression was compared with clinical and pathological parameters. In gliomas, BMI-1 expression was found in nearly all tumors analyzed, but the frequency of BMI-1 expressing cells was highly variable, ranging from 1 to 100%. In oligodendroglioma, BMI-1 expression was identified as a prognostic marker independent of tumor grade and clinical parameters. In pheochromocytoma, Snail expression was shown to distinguish between the metastatic and non-metastatic forms of the tumor. Snail expression was seen only in metastatic tumors, whereas non-metastatic tumors did not commonly express Snail. Finally, in oral carcinoma, BMI-1 expression was seen in roughly 80% of tumors, and Snail expression was high or very high in all cases. The lack of BMI-1 expression was associated with early relapse in oral carcinoma.

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Several previous studies indicate that among newly graduated PhDs, women tend to continue with a postdoctoral academic career to a lesser extent than men do. The Central PhD Student Council (CDR) has investigated to what degree this is also the case for Stockholm University. Using various sources, the relative change of the gender balance of PhD students compared to researchers at a postdoctoral level has been assessed at the four faculties of Stockholm University. For the Faculty of Science, the four different sections have been analysed as well. CDR finds that it is first and foremost at this faculty that a clear change in the gender balance between PhD students and postdoctoral researchers is discerned. Even though the variations between the individual departments and sections at the faculty are large, as a whole the relative decrease of the proportion of women is between 11 % and 21 %, depending on what metric is used. The dropoff of female researchers takes place primarily in already male-dominated areas of research. Unlike at the other faculties, we also find that the proportion of female senior lecturers at the Faculty of Science is lower than what could be expected. The proportion of female professors, even among new recruits, is still lower than the population of hypothetical recruits at all faculties – except at the Faculty of Humanities. We do, however, note that the proportion of female professors at the Faculty of Science is currently increasing and approaching that of the population of hypothetical recruits. At the Faculty of Social Sciences we see that, compared to the rest of the faculty, the proportion of women within the educational sciences is considerably higher and when excluding these subjects the trend towards more female professors disappears. CDR concludes that it is important to increase the directed efforts to encourage support to newly graduated female PhDs within male-dominated areas to stay in academia. Furthermore, it is crucial to study the reasons for a larger female drop-off within certain areas of research in the transition from PhD studies to a postdoctoral level. We further consider it important to ensure that women are given the same possibilities as men to qualify themselves scientifically and not be burdened with teaching and administrative duties to a larger extent than men are.