Iis--integrated Interactome System: A Web-based Platform For The Annotation, Analysis And Visualization Of Protein-metabolite-gene-drug Interactions By Integrating A Variety Of Data Sources And Tools.

High-throughput screening of physical, genetic and chemical-genetic interactions brings important perspectives in the Systems Biology field, as the analysis of these interactions provides new insights into protein/gene function, cellular metabolic variations and the validation of therapeutic targets and drug design. However, such analysis depends on a pipeline connecting different tools that can automatically integrate data from diverse sources and result in a more comprehensive dataset that can be properly interpreted. We describe here the Integrated Interactome System (IIS), an integrative platform with a web-based interface for the annotation, analysis and visualization of the interaction profiles of proteins/genes, metabolites and drugs of interest. IIS works in four connected modules: (i) Submission module, which receives raw data derived from Sanger sequencing (e.g. two-hybrid system); (ii) Search module, which enables the user to search for the processed reads to be assembled into contigs/singlets, or for lists of proteins/genes, metabolites and drugs of interest, and add them to the project; (iii) Annotation module, which assigns annotations from several databases for the contigs/singlets or lists of proteins/genes, generating tables with automatic annotation that can be manually curated; and (iv) Interactome module, which maps the contigs/singlets or the uploaded lists to entries in our integrated database, building networks that gather novel identified interactions, protein and metabolite expression/concentration levels, subcellular localization and computed topological metrics, GO biological processes and KEGG pathways enrichment. This module generates a XGMML file that can be imported into Cytoscape or be visualized directly on the web. We have developed IIS by the integration of diverse databases following the need of appropriate tools for a systematic analysis of physical, genetic and chemical-genetic interactions. IIS was validated with yeast two-hybrid, proteomics and metabolomics datasets, but it is also extendable to other datasets. IIS is freely available online at: http://www.lge.ibi.unicamp.br/lnbio/IIS/.

Fratris Nicolai, ordinis Minorum, chronicon de iis omnibus quae circa quaestionem tempore Joannis XXII. ortam de paupertate Christi et Apostolorum ejus, gesta et facta sunt, ab anno scilicet 1321. ad annum 1328.

Colbertinus

1.° Jacobi Alexandri le Taneur disputatio physico-mathematica de aequabili motus acceleratione, et de motu telluris : in qua Galilaei decreta de motu gravium perpendiculariter cadentium confirmantur ; et ostenditur vulgarem seu Ptolemaïcam de motu solis opinionem non minùs esse contrariam sacris litteris, quam Copernicanam de motu terrae : ac proinde nihil certi ex iis, quoad illam quaestionem, posse deduci : ad Petrum Cazraeum, societatis Jesu. — 2.° Ejusdem epistolae duae ad eundem, de descensu gravium. — 3.° Petri Cazraei, societatis Jesu, ad Alexandrum le Taneur epistola, qua sententiam Galilaei de descensu gravium impugnat. — 4.° Lettre de monsieur le Taneur au Pere Mersenne, Minime, sur la chûte des corps. — 5.° Ejusdem ad eundem epistola contra Fabrianam de incremento motus accelerati opinionem.

Melchisedechi Thevenotii

Forense Computacional em servidor IIS 5.0

Nas últimas décadas a utilização de computadores tornou-se parte integrante da vida das pessoas, permitindo o aparecimento de vários tipos de crimes electrónicos. Neste contexto, é importante que as organizações se preparem para investigar casos que envolvem a informática e adoptem procedimentos válidos e confiáveis que permitem recuperar os dados dos computadores envolvidos em actividades ilícitas. A Forense Computacional, são técnicas que permitem-nos recolher, identificar, analisar e apresentar evidências de crimes digitais. Pretende-se com este trabalho, apresentar as principais técnicas de Forense Computacional em servidor IIS 5.0 da Microsoft.

1.° Fratris Bernardi de Virduno, ordinis Minorum, liber super totam astrologiam. — 2.° Liber de compositione et practica instrumenti astronomici, quod dicitur Turketus. — 3.° Tractatus de almanach : authore anonymo. — 4.° Theorica planetarum : authore Gerardo Carmonensi. — 5.° Liber Thebit de motu octavae sphaerae. — 6.° Ejusdem liber de iis quae indigent expositione antequam legatur almagestum Ptolemaei. — 7.° Ejusdem liber de imaginatione sphaerae et circulorum ejus diversorum. — 8.° Ejusdem liber de quantitatibus stellarum et planetarum.

Colbertinus

Niini- Iis- ja Virmavesi

0-meridiaani : Greenwich

De iis quae in religione christiana ignorantur

Arkit: A4 B2.

Moses seu de iis quae in magno illo merito suspiciuntur

Variantti A.

Moses seu de iis quae in magno illo merito suspiciuntur

Variantti C.

Moses seu de iis quae in magno illo merito suspiciuntur

Variantti B. Vallinkosken mukaan luultavasti korrehtuurikappale.

"Theophrastus redivivus, sive historia de iis quae dicuntur de Diis, de mundo, de religione, de anima, etc.".

Note "donné à la Bibliothèque le [...] 1741" de la main de l'abbé Sallier (f. de garde); — provient de la bibliothèque du comte d'Hoym dispersée en vente publique en août 1738 mais ne figure pas dans l'"Etat des livres achetés par M. l'abbé Sallier pour la Bibliotheque du roy à la vente des livres de M. le comte de Hoym en aoust 1738"; cf. latin 17173, f. 167-171; — cote 381

Papiers de Dom Jean MABILLON (1707). II « Index universalis indicans varias quæstiones et materias ac autores qui de iis pertractarunt, » par Mabillon.

Contient : « Indiculus sanctorum monachorum, cum primis et extremis verbis Actorum quæ penes nos habentur, » par Mabillon

Theologia scholastica tractatus omnes in universitatibus provinciae germaniae superioris Societatis Jesu tradi solitos et quaestiones in iis praescriptas complexa

UANL