Commentatio de Golgothae et sanctissimi D.N.J.C. supulcri situ.

"Solemnia natalitia regis augustissimi ac potentissimi Friderici Guilelmi III. die III. Augusti ab alma Academia Borussica Rhenana publice pieque celebranda rectoris ac senatus nomine."

Io. Laur. Moshemii Commentatio de lumine sancti sepulchri. --

Title vignette.

Pilgrimage to the Holy Land Commemorative Medal

Obverse: A 16th century map drawn by a German cartographer Heinrich Bintung, which shows Jerusalem standing in the center of the three continents. Reverse: Inscription.

Letter from Jews of Amsterdam to Jews of Baltimore, regarding Jews of the Holy Land

Digital image

The Holy Grail of Polymer Therapeutics for Cancer Therapy: An Overview on the Pharmacokinetics and Bio Distribution

In recent years, multifaceted clinical benefits of polymeric therapeutics have been reported. Over the past decades, cancer has been one of the leading causes of mortality in the world. Many clinically approved chemotherapeutics encounter potential challenges against deadly cancer. Moreover, safety and efficacy of anticancer agents have been limited by undesirable pharmacokinetics and biodistribution. To address these limitations, various polymer drug conjugates are being studied and developed to improve the antitumor efficacy. Among other therapeutics, polymer therapeutics are well established platforms that circumvent anticancer therapeutics from enzymatic metabolism via direct conjugation to therapeutic molecules. Interestingly, polymer therapeutics meets an unmet need of small molecules. Further clinical study showed that polymer-drug conjugation can achieve desired pharmacokinetics and biodistribution properties of several anticancer drugs. The present retrospective review mainly enlightens the most recent preclinical and clinical studies include safety, stability, pharmacokinetic behavior and distribution of polymer therapeutics.

"Rapid and dramatic changes in vegetation" of a small pond on Holy Island (Northumbria): Chaotic dynamics?

This note describes changes to the relative extent of four structurally dominant submerged macrophytes in a pond on Holy Island National Nature Reserve, Northumbria, between 1991 and 1998. The estimated extent of the four submerged macrophytes and bare substratum between 1991 and 1998 showed dramatic changes with no obvious pattern or periodicity, as well as no identifiable natural or anthropogenic causes. Chaotic variation may be an important character of submerged pond plant populations, so that surveys taken in a single year may give an unreliable picture of plant populations.