The life and letters of Sir George Savile, Bart., first Marquis of Halifax &c.

Works, and Appendix of attributed works: v. 2, p. 269-541.

Some unpublished letters of Gilbert Burnet, the historian /

Forms part of the Royal historical society's Publications, Camden third series, vol.XIII.

Essays political and biographical,

Mode of access: Internet.

Miscellanies /

Mode of access: Internet.

Calendar of the manuscripts of the Marquis of Bath preserved at Longleat, Wiltshire /

Vols. 1 and 3 edited by J. J. Cartwright and J. M. Rigg; v. 2, by Mrs. S. C. Lomas; v. 4, by Marjorie Blatcher; v. 5, by G. Dyfnallt Owen.

Letter to George Rykert (president of the Port Dalhousie and Thorold Railway), engineer from William Danforth, civil engineer

Letter to George Rykert (president of the Port Dalhousie and Thorold Railway), engineer from William Danforth, civil engineer in which he states that the preliminary survey has been made between Port Dalhousie and Centreville at which point it may intersect with the Great Western Railway. The estimate is included (2 pages, handwritten), July 25, 1853.

Indenture of Bargain and Sale (vellum) between Captain George Salmon, formerly of Upper Canada and now of Middlesex, England and Charles Hampden Turner of Surrey, England

Indenture of Bargain and Sale (vellum) between Captain George Salmon, formerly of Upper Canada and now of Middlesex, England and Charles Hampden Turner of Surrey, England for 1,200 acres lying in the Township of Windham in the County of Norfolk in the province of Upper Canada, May 5, 1819.

The demise of Bicycle George : a life of crime

This short piece looks at the life of a murderer, George Blunderfield (alias Arthur Oldring), who was hanged in Melbourne in 1918. Melburnians, or visitors to the city, may have seen his image on the wall at the Old Melbourne Gaol. Blunderfield's life started out normally
enough, and then descended into horrific crime. His story includes bicycle racing, escape from an island prison, and then recruitment for service with the Australian Imperial Forces in wartime Victoria. In the last years of his life, Blunderfield wreaked havoc from the western to the eastern coasts of Australia. This in turn had a dramatic effect on his immediate family, which is also detailed here. This story draws on the archives at PROV as well as on State Records Office of Western Australia material, with help from Ms Jean
Bellamy, a distant relative of George Blunderfield.

George 2nd Earl of Warwick [Material gráfico] : From the original picture in the possession of the Earl Warwick

Resumen: Descripción: retrato de niño de tres cuartos de figura mirando de frente

The Rat Myosin myr 5 Is a GTPase-activating Protein for Rho In Vivo: Essential Role of Arginine 1695

myr 5 is an unconventional myosin (class IX) from rat that contains a Rho-family GTPase-activating protein (GAP) domain. Herein we addressed the specificity of the myr 5 GAP activity, the molecular mechanism by which GAPs activate GTP hydrolysis, the consequences of myr 5 overexpression in living cells, and its subcellular localization. The myr 5 GAP activity exhibits a high specificity for Rho. To achieve similar rates of GTPase activation for RhoA, Cdc42Hs, and Rac1, a 100-fold or 1000-fold higher concentration of recombinant myr 5 GAP domain was needed for Cdc42Hs or Rac1, respectively, as compared with RhoA. Cell lysates from Sf9 insect cells infected with recombinant baculovirus encoding myr 5 exhibited increased GAP activity for RhoA but not for Cdc42Hs or Rac1. Analysis of Rho-family GAP domain sequences for conserved arginine residues that might contribute to accelerate GTP hydrolysis revealed a single conserved arginine residue. Mutation of the corresponding arginine residue in the myr 5 GAP domain to a methionine (M1695) virtually abolished Rho-GAP activity. Expression of myr 5 in Sf9 insect cells induced the formation of numerous long thin processes containing occasional varicosities. Such morphological changes were dependent on the myr 5 Rho-GAP activity, because they were induced by expressing the myr 5 tail or just the myr 5 Rho-GAP domain but not by expressing the myr 5 myosin domain. Expression of myr 5 in mammalian normal rat kidney (NRK) or HtTA-1 HeLa cells induced a loss of actin stress fibers and focal contacts with concomitant morphological changes and rounding up of the cells. Similar morphological changes were observed in HtTA-1 HeLa cells expressing just the myr 5 Rho-GAP domain but not in cells expressing myr 5 M1695. These morphological changes induced by myr 5 were inhibited by coexpression of RhoV14, which is defective in GTP hydrolysis, but not by RhoI117. myr 5 was localized in dynamic regions of the cell periphery, in the perinuclear region in the Golgi area, along stress fibers, and in the cytosol. These results demonstrate that myr 5 has in vitro and in vivo Rho-GAP activity. No evidence for a Rho effector function of the myr 5 myosin domain was obtained.