Submission to the Attorney-General's Department consultation on "Marrakesh Treaty options for implementation" discussion paper

It is extremely important to ensure that people with disabilities can access information and cultural works on an equal basis with others. Access is fundamentally important to enable people with disabilities to fully participate in economic, social, and political life. This is both a pressing moral imperative and a legal requirement in international law. Australia should take clear steps to affirmatively redress the fundamental inequalities of access that people with disabilities face. This requires a fundamental shift in the way that we think about copyright and disability rights: the mechanisms for enabling access should not be a limited exception to normal distribution, but should instead be strong positive rights that are able to be routinely and practically exercised.

Copper Range Railroad General Freight Department Rules and Regulations

http://digitalcommons.mtu.edu/copper_range/1000/thumbnail.jpg

General Reference Department staff manual,

Mode of access: Internet.

Opinions of Attorney General and Department of Labor on Workmen's Compensation Act.

Title from cover.

La Escuela de Bibliotecología de la Provincia de Buenos Aires y la profesionalización del bibliotecario (1948-1950)

El presente trabajo indaga sobre los orígenes de la enseñanza bibliotecológica en la ciudad de La Plata, tomando como eje fundamental la creación de la Escuela de Bibliotecología por parte de la Dirección General de Bibliotecas de la Provincia de Buenos Aires. Se describen las principales características de las instituciones de enseñanza de bibliotecología existentes en la región hasta el año 1950, en función de interpretar cuáles fueron los antecedentes que dieron lugar a la formación de dicha Escuela. Luego se presenta la situación político-social en el contexto del primer gobierno peronista bonaerense. Finalmente, se abordan los contenidos existentes en los planes de estudio de las carreras con el objetivo de delinear el ideal de profesional bibliotecario que se deseaba alcanzar de acuerdo a las políticas culturales del Estado provincial. Se concluye que, a través de esta institución educativa, se intentó formar un profesional bibliotecario con múltiples aptitudes; un agente cultural capaz de guiar a los lectores hacia los libros de edición nacional con un rol docente, en estrecha relación con el maestro y con los alumnos en todos los niveles de formación.

La Escuela de Bibliotecología de la Provincia de Buenos Aires y la profesionalización del bibliotecario (1948-1950)

El presente trabajo indaga sobre los orígenes de la enseñanza bibliotecológica en la ciudad de La Plata, tomando como eje fundamental la creación de la Escuela de Bibliotecología por parte de la Dirección General de Bibliotecas de la Provincia de Buenos Aires. Se describen las principales características de las instituciones de enseñanza de bibliotecología existentes en la región hasta el año 1950, en función de interpretar cuáles fueron los antecedentes que dieron lugar a la formación de dicha Escuela. Luego se presenta la situación político-social en el contexto del primer gobierno peronista bonaerense. Finalmente, se abordan los contenidos existentes en los planes de estudio de las carreras con el objetivo de delinear el ideal de profesional bibliotecario que se deseaba alcanzar de acuerdo a las políticas culturales del Estado provincial. Se concluye que, a través de esta institución educativa, se intentó formar un profesional bibliotecario con múltiples aptitudes; un agente cultural capaz de guiar a los lectores hacia los libros de edición nacional con un rol docente, en estrecha relación con el maestro y con los alumnos en todos los niveles de formación.

La Escuela de Bibliotecología de la Provincia de Buenos Aires y la profesionalización del bibliotecario (1948-1950)

El presente trabajo indaga sobre los orígenes de la enseñanza bibliotecológica en la ciudad de La Plata, tomando como eje fundamental la creación de la Escuela de Bibliotecología por parte de la Dirección General de Bibliotecas de la Provincia de Buenos Aires. Se describen las principales características de las instituciones de enseñanza de bibliotecología existentes en la región hasta el año 1950, en función de interpretar cuáles fueron los antecedentes que dieron lugar a la formación de dicha Escuela. Luego se presenta la situación político-social en el contexto del primer gobierno peronista bonaerense. Finalmente, se abordan los contenidos existentes en los planes de estudio de las carreras con el objetivo de delinear el ideal de profesional bibliotecario que se deseaba alcanzar de acuerdo a las políticas culturales del Estado provincial. Se concluye que, a través de esta institución educativa, se intentó formar un profesional bibliotecario con múltiples aptitudes; un agente cultural capaz de guiar a los lectores hacia los libros de edición nacional con un rol docente, en estrecha relación con el maestro y con los alumnos en todos los niveles de formación.

Report of provost marshal general.

"History of the Provost Marshal General's Department, American Expeditionary Forces (for the report of the commander-in-chief)"--p. ii.

Evaluation of Indigenous justice programs.: final report / Project D, Safe Aboriginal Youth Patrol Programs in New South Wales and Northbridge Policy and Juvenile Aid Group in Western Australia

The Australian Government has provided funding to evaluate the effectiveness of Indigenous law and justice programs across five subject areas to identify the best approaches to tackling crime and justice issues and better inform government funding decisions in the future. This report presents the findings of subject area "D", which examined two different approaches to delivering community and night patrol services for young people: the Safe Aboriginal Youth Patrol programs in New South Wales, and the Northbridge Policy project (the Young People in Northbridge project), in Western Australia. Night patrols can address crime either directly or indirectly, by prevention work or by addressing the social causes of crime through community development.

Microbe-induced Innate Immune Responses in Human Dendritic Cells

Two types of antigen-presenting cells (APCs), macrophages and dendritic cells (DCs), function at the interface of innate and adaptive immunity. Through recognition of conserved microbial patterns, they are able to detect the invading pathogens. This leads to activation of signal transduction pathways that in turn induce gene expression of various molecules required for immune responses and eventually pathogen clearance. Cytokines are among the genes induced upon detection of microbes. They play an important role in regulating host immune responses during microbial infection. Chemotactic cytokines, chemokines, are involved in migratory events of immune cells. Cytokines also promote the differentiation of distinct T cell responses. Because of the multiple roles of cytokines in the immune system, the cytokine network needs to be tightly regulated. In this work, the induction of innate immune responses was studied using human primary macrophages or DCs as cell models. Salmonella enterica serovar Typhimurium served as a model for an intracellular bacterium, whereas Sendai virus was used in virus experiments. The starting point of this study was that DCs of mouse origin had recently been characterized as host cells for Salmonella. However, only little was known about the immune responses initiated in Salmonella-infected human DCs. Thus, cellular responses of macrophages and DCs, in particular the pattern of cytokine production, to Salmonella infection were compared. Salmonella-induced macrophages and DCs were found to produce multiple cytokines including interferon (IFN) -gamma, which is conventionally produced by T and natural killer (NK) cells. Both macrophages and DCs also promoted the intracellular survival of the bacterium. Phenotypic maturation of DCs as characterized by upregulation of costimulatory and human leukocyte antigen (HLA) molecules, and production of CCL19 chemokine, were also detected upon infection with Salmonella. Another focus of this PhD work was to unravel the regulatory events controlling the expression of cytokine genes encoding for CCL19 and type III IFNs, which are central to DC biology. We found that the promoters of CCL19 and type III IFNs contain similar regulatory elements that bind nuclear factor kappaB (NF-kappaB) and interferon regulatory factors (IRFs), which could mediate transcriptional activation of the genes. The regulation of type III IFNs in virus infection resembled that of type I IFNs a cytokine class traditionally regarded as antiviral. The induction of type I and type III IFNs was also observed in response to bacterial infection. Taken together, this work identifies new details about the interaction of Salmonella with its phagocytic host cells of human origin. In addition, studies provide information on the regulatory events controlling the expression of CCL19 and the most recently identified IFN family genes, type III IFN genes.

Microbe-induced activation of inflammatory cytokine response in human cells

Human body is in continuous contact with microbes. Although many microbes are harmless or beneficial for humans, pathogenic microbes possess a threat to wellbeing. Antimicrobial protection is provided by the immune system, which can be functionally divided into two parts, namely innate and adaptive immunity. The key players of the innate immunity are phagocytic white blood cells such as neutrophils, monocytes, macrophages and dendritic cells (DCs), which constantly monitor the blood and peripheral tissues. These cells are armed for rapid activation upon microbial contact since they express a variety of microbe-recognizing receptors. Macrophages and DCs also act as antigen presenting cells (APCs) and play an important role in the development of adaptive immunity. The development of adaptive immunity requires intimate cooperation between APCs and T lymphocytes and results in microbe-specific immune responses. Moreover, adaptive immunity generates immunological memory, which rapidly and efficiently protects the host from reinfection. Properly functioning immune system requires efficient communication between cells. Cytokines are proteins, which mediate intercellular communication together with direct cell-cell contacts. Immune cells produce inflammatory cytokines rapidly following microbial contact. Inflammatory cytokines modulate the development of local immune response by binding to cell surface receptors, which results in the activation of intracellular signalling and modulates target cell gene expression. One class of inflammatory cytokines chemokines has a major role in regulating cellular traffic. Locally produced inflammatory chemokines guide the recruitment of effector cells to the site of inflammation during microbial infection. In this study two key questions were addressed. First, the ability of pathogenic and non-pathogenic Gram-positive bacteria to activate inflammatory cytokine and chemokine production in different human APCs was compared. In these studies macrophages and DCs were stimulated with pathogenic Steptococcus pyogenes or non-pathogenic Lactobacillus rhamnosus. The second aim of this thesis work was to analyze the role of pro-inflammatory cytokines in the regulation of microbe-induced chemokine production. In these studies bacteria-stimulated macrophages and influenza A virus-infected lung epithelial cells were used as model systems. The results of this study show that although macrophages and DCs share several common antimicrobial functions, these cells have significantly distinct responses against pathogenic and non-pathogenic Gram-positive bacteria. Macrophages were activated in a nearly similar fashion by pathogenic S. pyogenes and non-pathogenic L. rhamnosus. Both bacteria induced the production of similar core set of inflammatory chemokines consisting of several CC-class chemokines and CXCL8. These chemokines attract monocytes, neutrophils, dendritic cells and T cells. Thus, the results suggest that bacteria-activated macrophages efficiently recruit other effector cells to the site of inflammation. Moreover, macrophages seem to be activated by all bacteria irrespective of their pathogenicity. DCs, in contrast, were efficiently activated only by pathogenic S. pyogenes, which induced DC maturation and production of several inflammatory cytokines and chemokines. In contrast, L. rhamnosus-stimulated DCs matured only partially and, most importantly, these cells did not produce inflammatory cytokines or chemokines. L. rhamnosus-stimulated DCs had a phenotype of "semi-mature" DCs and this type of DCs have been suggested to enhance tolerogenic adaptive immune responses. Since DCs have an essential role in the development of adaptive immune response the results suggest that, in contrast to macrophages, DCs may be able to discriminate between pathogenic and non-pathogenic bacteria and thus mount appropriate inflammatory or tolerogenic adaptive immune response depending on the microbe in question. The results of this study also show that pro-inflammatory cytokines can contribute to microbe-induced chemokine production at multiple levels. S. pyogenes-induced type I interferon (IFN) was found to enhance the production of certain inflammatory chemokines in macrophages during bacterial stimulation. Thus, bacteria-induced chemokine production is regulated by direct (microbe-induced) and indirect (pro-inflammatory cytokine-induced) mechanisms during inflammation. In epithelial cells IFN- and tumor necrosis factor- (TNF-) were found to enhance the expression of PRRs and components of cellular signal transduction machinery. Pre-treatment of epithelial cells with these cytokines prior to virus infection resulted in markedly enhanced chemokine response compared to untreated cells. In conclusion, the results obtained from this study show that pro-inflammatory cytokines can enhance microbe-induced chemokine production during microbial infection by providing a positive feedback loop. In addition, pro-inflammatory cytokines can render normally low-responding cells to high chemokine producers via enhancement of microbial detection and signal transduction.

Modern computed tomography techniques in stroke management

Technological development of fast multi-sectional, helical computed tomography (CT) scanners has allowed computed tomography perfusion (CTp) and angiography (CTA) in evaluating acute ischemic stroke. This study focuses on new multidetector computed tomography techniques, namely whole-brain and first-pass CT perfusion plus CTA of carotid arteries. Whole-brain CTp data is acquired during slow infusion of contrast material to achieve constant contrast concentration in the cerebral vasculature. From these data quantitative maps are constructed of perfused cerebral blood volume (pCBV). The probability curve of cerebral infarction as a function of normalized pCBV was determined in patients with acute ischemic stroke. Normalized pCBV, expressed as a percentage of contralateral normal brain pCBV, was determined in the infarction core and in regions just inside and outside the boundary between infarcted and noninfarcted brain. Corresponding probabilities of infarction were 0.99, 0.96, and 0.11, R² was 0.73, and differences in perfusion between core and inner and outer bands were highly significant. Thus a probability of infarction curve can help predict the likelihood of infarction as a function of percentage normalized pCBV. First-pass CT perfusion is based on continuous cine imaging over a selected brain area during a bolus injection of contrast. During its first passage, contrast material compartmentalizes in the intravascular space, resulting in transient tissue enhancement. Functional maps such as cerebral blood flow (CBF), and volume (CBV), and mean transit time (MTT) are then constructed. We compared the effects of three different iodine concentrations (300, 350, or 400 mg/mL) on peak enhancement of normal brain tissue and artery and vein, stratified by region-of-interest (ROI) location, in 102 patients within 3 hours of stroke onset. A monotonic increasing peak opacification was evident at all ROI locations, suggesting that CTp evaluation of patients with acute stroke is best performed with the highest available concentration of contrast agent. In another study we investigated whether lesion volumes on CBV, CBF, and MTT maps within 3 hours of stroke onset predict final infarct volume, and whether all these parameters are needed for triage to intravenous recombinant tissue plasminogen activator (IV-rtPA). The effect of IV-rtPA on the affected brain by measuring salvaged tissue volume in patients receiving IV-rtPA and in controls was investigated also. CBV lesion volume did not necessarily represent dead tissue. MTT lesion volume alone can serve to identify the upper size limit of the abnormally perfused brain, and those with IV-rtPA salvaged more brain than did controls. Carotid CTA was compared with carotid DSA in grading of stenosis in patients with stroke symptoms. In CTA, the grade of stenosis was determined by means of axial source and maximum intensity projection (MIP) images as well as a semiautomatic vessel analysis. CTA provides an adequate, less invasive alternative to conventional DSA, although tending to underestimate clinically relevant grades of stenosis.

Características dos serviços de auditoria interna em empresas estatais: o caso das empresas do estado do Ceará

o objetivo desta pesquisa foi analisar, através de um estudo exploratório, o funcionamento dos serviços de Auditoria Interna e conhecer as práticas atualmente empre gadas em três empresas estatais do Estado do Ceará, à luz de urna comparaçao com os fundamentos teóricos sobre Interna. Auditoria "Na revisão da literatura apresenta-se a perspectiva histórica, evidenciando o surgimento e desenvolvime~ to da Auditoria Interna, destacando-se principalmente os aspectos mais relevant"es. A seguir, são apresentadas consideraçoes gerais sobre Auditoria Interna em empresas estatais. A partir dessa revisão foi possível desenvolver um plano de referência para ser utilizado nesta pesquisa. A metodologia adotada neste trabalho foi o es tudo de caso, e as razoes de seu emprego são justificadas além das limitações desse tipo de estudo exploratório. , Entrevistas, utilizando questionários, compos tos em sua maioria de questões abertas, permitiram urna descrição dos serviços de Auditoria Interna desenvolvidos pelas empresas estatais estaduais, bem corno as informações obtidas no Departamento de Auditoria Geral do Estado, além da Comissão de Auditoria Administrativa do Estado do Ceará.Os resultados obtidos possibilitaram uma análise sobre as características dos serviços de Auditoria Interna projetados pelas empresas estatais estaduais, bem como sobre o funcionamento desses serviços e as práticas desenvol vidas pelas empresas pesquisadas. Finalmente, comparando-se os resultados da pesquisa de campo com a literatura existente, pode-se chegar a algumas conclusões importantes, como também formular recomendações para o Governo Estadual e para as empresas pesquisadas, além de algumas sugestões para pesquisas futuras.

Gold Company Claims, Witwatersrand, South Africa, 1895 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Bacon's new map of the Witwatersrand goldfields in the districts of Pretoria and Heidelberg, Transvaal, S. A. R. : shewing the main and other reefs, with the farms, gold mining company's claims and concessions : from information in the Surveyor-General's Department. It was published by G. W. Bacon & Co. in 1895. Scale [ca. 1:88,992].The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM Zone 35S, meters, WGS 1984) projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, roads, railroads, cities and other human settlements, administrative boundaries, farms, homesteads, main reefs, other reefs, probable connections, and mills. Includes also notes and inset: "Enlarged map of the farms Lanlaagte, Turffontein, Dornfontein & Elandsfontein, shewing the boundaries of the principal deep level gold mining coys. on the Witwatersrand goldfields" and a geological profile of the area north of Magaliesberg to the south of Witwatersrange.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Tabulation of war and emergency legislation relating to the Navy. Revision 3, effective as of 31 December 1948.

Mode of access: Internet.