Life and letters of James David Forbes, F.R.S., D.C.L., LL. D., late principal of the United college in the University of St. Andrews ...

"List of Principal Forbes' scientific writings": p. [567]-577.

Travels through the Alps of Savoy and other parts of the Pennine chain : with observations on the phenomena of glaciers /

Includes index.

Kit Carson days (1809-1868)

Includes bibliographical references and index.

The Reformed Presbyterian and covenanter.

Editors: 1863-73, Thomas Sproull (1863-66, with J.M. Willson; 1868-73, with J.W. Sproull); 1874-95, J.W. Sproull and D.B. Willson.

Schreiben des ehrwürdigen Chefs des Kaiserl. Königl. Central-Consistoriums der Israeliten, Herrn David Sinsheim zu Paris, an den Herausgeber dieser Zeitschrift

David Sinsheim

Yokohama-shi & Kanagawa-ken Region, Japan, 1868 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Descriptive map, shewing the Treaty limits round Yokohama : including the Province of Sagami & portions of Kai, Idzu, Musasi & Suraga, compiled and drawn by Lieut. A.G.S. Hawes, 1865-67. It was published by James Wyld in 1868. Scale [ca. 1:57,217]. Covers the Yokohama-shi & Kanagawa-ken region, Japan. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Tokyo Universal Transverse Mercator (UTM) Zone 54N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as cities and towns, roads, railroads and stations, drainage, built-up areas and selected buildings, fortification, district and province boundaries, temples, baths, ruins, battle sites, and more. Relief shown by shading. Includes notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

A system of mechanical philosophy.

Vol. 2 has added t.-p.: The articles Steam and Steam-engines, written for the Encyclopædia britannica by John Robison ... With notes and additions by James Watt ... And a letter on some properties of steam by the late John Southern, esq.

The Spottiswoode miscellany: a collection of original papers and tracts, illustrative chiefly of the civil and ecclesiastical history of Scotland ...

Title of Vol. II reads : Edited by James Maidment.

Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanism

Insulin stimulates glucose transport in adipocytes and muscle cells by triggering redistribution of the GLUT4 glucose transporter from an intracellular perinuclear location to the cell surface. Recent reports have shown that the microtubule-depolymerizing agent nocodazole inhibits insulin-stimulated glucose transport, implicating an important role for microtubules in this process. In the present study we show that 2 mum nocodazole completely depolymerized microtubules in 3T3-L1 adipocytes, as determined morphologically and biochemically, resulting in dispersal of the perinuclear GLUT4 compartment and the Golgi apparatus. However, 2 mum nocodazole did not significantly effect either the kinetics or magnitude of insulin-stimulated glucose transport. Consistent with previous studies, higher concentrations of nocodazole (10-33 mum) significantly inhibited basal and insulin-stimulated glucose uptake in adi. pocytes. This effect was not likely the result of microtubule depolymerization because in the presence of taxol, which blocked nocodazole-induced depolymerization of microtubules as well as the dispersal of the perinuclear GLUT4 compartment, the inhibitory effect of 10-33 muM nocodazole on insulin-stimulated glucose uptake prevailed. Despite the decrease in insulin-stimulated glucose transport with 33 muM nocodazole we did not observe inhibition of insulin-stimulated GLUT4 translocation to the cell surface under these conditions. Consistent with a direct effect of nocodazole on glucose transporter function we observed a rapid inhibitory effect of nocodazole on glucose transport activity when added to either 3T3-L1 adipocytes or to Chinese hamster ovary cells at 4 degreesC. These studies reveal a new and unexpected effect of nocodazole in mammalian cells which appears to occur independently of its microtubule-depolymerizing effects.