From crow-scaring to Westminster : an autobiography /

Mode of access: Internet.

The life of President Edwards:

Microfilm. Ann Arbor, Mich., University Microfilms [n.d.] (American culture series, Reel 491.7)

THE MOLECULAR INTERACTION BETWEEN TYPE II DIABETES AND ALZHEIMER’S DISEASE THROUGH CROSS-SEEDING OF PROTEIN MISFOLDING

With the population of the world aging, the prominence of diseases such as Type II Diabetes (T2D) and Alzheimer’s disease (AD) are on the rise. In addition, patients with T2D have an increased risk of developing AD compared to age-matched individuals, and the number of AD patients with T2D is higher than among aged-matched non-AD patients. AD is a chronic and progressive dementia characterized by amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), neuronal loss, brain inflammation, and cognitive impairment. T2D involves the dysfunctional use of pancreatic insulin by the body resulting in insulin resistance, hyperglycemia, hyperinsulinemia, pancreatic beta cell (β-cell) death, and other complications. T2D and AD are considered protein misfolding disorders (PMDs). PMDs are characterized by the presence of misfolded protein aggregates, such as in T2D pancreas (islet amyloid polypeptide - IAPP) and in AD brain (amyloid– Aβ) of affected individuals. The misfolding and accumulation of these proteins follows a seeding-nucleation model where misfolded soluble oligomers act as nuclei to propagate misfolding by recruiting other native proteins. Cross-seeding occurs when oligomers composed by one protein seed the aggregation of a different protein. Our hypothesis is that the pathological interactions between T2D and AD may in part occur through cross-seeding of protein misfolding. To test this hypothesis, we examined how each respective aggregate (Aβ or IAPP) affects the disparate disease pathology through in vitro and in vivo studies. Assaying Aβ aggregates influence on T2D pathology, IAPP+/+/APPSwe+/- double transgenic (DTg) mice exhibited exacerbated T2D-like pathology as seen in elevated hyperglycemia compared to controls; in addition, IAPP levels in the pancreas are highest compared to controls. Moreover, IAPP+/+/APPSwe+/- animals demonstrate abundant plaque formation and greater plaque density in cortical and hippocampal areas in comparison to controls. Indeed, IAPP+/+/APPSwe+/- exhibit a colocalization of both misfolded proteins in cerebral plaques suggesting IAPP may directly interact with Aβ and aggravate AD pathology. In conclusion, these studies suggest that cross-seeding between IAPP and Aβ may occur, and that these protein aggregates exacerbate and accelerate disease pathology, respectively. Further mechanistic studies are necessary to determine how these two proteins interact and aggravate both pancreatic and brain pathologies.

A practical guide for emigrants to North America, including the United States, Lower and Upper Canada, and Newfoundland; with full information respecting ... matters requisite for the emigrant to become acquainted with before embarking ...

Howes N54.

Enemies of the rose.

"National Rose Society's Handbook on the fungus and insect pests of the rose."

A treatise on the powers and duties of justices of the peace and town officers, in the state of New York, under the revised statutes; with practical forms.

Mode of access: Internet.

A preliminary report on the electrical resistivity survey at Medicine Lake, Montana /

Mode of access: Internet.

Theology : explained and defended, in a series of sermons. With a memoir of the life of the author.

Vol. 2 lacks title-page and all before p. v.

A monography of the Myxogastres.

Bibliography: p. 356-359.

A natural history of uncommon birds, and of some other rare and undescribed animals : quadrupeds, fishes, reptiles, insects, &c. : exhibited in two hundred and ten copper-plates, ... In four parts /

"A Natural history of birds : most of wich have not been figur'd or describ'd ... : containing the figures of sixty birds and two quadrupedes ... / by Geroge Edwards ..."

Gleanings of natural history, exhibiting figures of quadrupedes, birds, plants, etc. Most of which have not, till now, been either figured or described : with descriptions of seventy different subjects, designed, engraved, and coloured after nature, on fifty copper-plate prints /

Mode of access: Internet.

Gleanings of natural history, exhibiting figures of quadrupedes, birds, plants, etc. Most of which have not, till now, been either figured or described : with descriptions of seventy different subjects, designed, engraved, and coloured after nature, on fifty copper-plate prints : part II /

Mode of access: Internet.

Gleanings of natural history, exhibiting figures of quadrupedes, birds, plants, etc. Most of which have not, till now, been either figured or described : with descriptions of seventy different subjects, designed, engraved, and coloured after nature, on fifty copper-plate prints : part III /

Mode of access: Internet.

A natural history of birds : most of which have not been figured or described, and others very little known, from obscure ... : containing the figures of sixty-one birds and two quadrupedes ...: to wich is added, an appendix, by way of illustration : part II /

Forma parte de la obra completa: "A natural history of uncommon birds, and of some other rare and undescribed animals ..."