980 resultados para Duke, Richard
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This article explores the bilingual and bicultural identity of Normandy revealed by Wace's depiction of Duke Richard the Fearless in the Roman de Rou. The anecdotes that open the Troisieme Partie of the Rou are analysed in the light of Scandinavian analogues, in particular the Saga of Grettir. This allows us to discern in Wace's stories a dual tradition, with romance and scandinavian strands that were not always mutually compatible, resulting in narrative tensions that had hitherto remained unexplained. In particular, the fearless duke takes on connotations of mental instability that would only have been recognised by the Normans of Danish origin.
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Although adenovirus can infect a wide range of cell types, lymphocytes are not generally susceptible to adenovirus infection, in part because of the absence of the expression of the cellular receptor for the adenoviral fiber protein. The cellular receptor for adenovirus and coxsackievirus (CAR) recently was cloned and shown to mediate adenoviral entry by interaction with the viral fiber protein. We show that the ectopic expression of CAR in various lymphocyte cell lines, which are almost completely resistant to adenovirus infection, is sufficient to facilitate the efficient transduction of these cells by recombinant adenoviruses. Furthermore, this property of CAR does not require its cytoplasmic domain, consistent with the idea that CAR primarily serves as a high affinity binding site for the adenoviral fiber protein, and that viral entry is mediated by interaction of the viral penton base proteins with cellular integrins. As a demonstration of their functional utility, we used CAR-expressing lymphocytes transduced with an adenovirus expressing Fas ligand to efficiently kill Fas receptor-expressing tumor cells. The ability to efficiently manipulate gene expression in lymphocyte cells by using adenovirus vectors should facilitate the functional characterization of pathways affecting lymphocyte physiology.
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Mode of access: Internet.
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UANL
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Leaf A₂ mis-signed as A₁.
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Mode of access: Internet.
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Titles vary: v. 5 has title, "Civil correspondence and memoranda"; v. 6-15 have title, "Supplementary despatches. Correspondence and memoranda. "
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v.1. 1819-1822.--v.2. 1823-1825.--v.3. 1825-1827.--v.4. 1827-1828.--v.5. 1828-1829.--v.6. 1829-1830.--v.7. 1830-1831.--v.8. 1831-1832.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.