979 resultados para Clarke, Thomas B.
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Presentation copy to Frank Jewett Mather, jr., with collector's autograph.
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Mode of access: Internet.
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Printed copy of an undated abstract of laws and regulations with the admittatur of undergraduate Thomas Bartlett Hall to the Sophomore class on probation signed by President Josiah Quincy on August 27, 1840. The admittatur identifies Hall as a sophomore.
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Four-page handwritten account statement of the estate of Caleb Gannett with the note on the verso: "This account of administration was rendered the Judge, but was declared by him to be incorrect-- Feb 1819."
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Four-page handwritten account statement with the note on the verso: "Thomas B. Gannett's first account as executor to C. Gannett February 1820 copy."
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One-page handwritten accounting document with the note on the verso: "changes of from which items in 1st account of administration are formed." The document is undated.
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Mode of access: Internet.
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"The book-lover's Camden edition."
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Mode of access: Internet.
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First published 1914, under title: The life of Thomas Brackett Reed.
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Includes index.
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The small envelope protein of hepatitis B virus (HBsAg-S) can self-assemble into highly organized virus like particles (VLPs) and induce an effective immune response. In this study, a restriction enzyme site was engineered into the cDNA of HBsAg-S at a position corresponding to the exposed site within the hydrophilic a determinant region (amino acid [aa] 127-128) to create a novel HBsAg vaccine vector allowing surface orientation of the inserted sequence. We inserted sequences of various lengths from hypervariable region 1 (HVR1) of the hepatitis C virus (HCV) E2 protein containing immunodominant epitopes and demonstrated secretion of the recombinant HBsAg VLPs from transfected mammalian cells. A number of different recombinant proteins were synthesized, and HBsAg VLPs containing inserts up to 36 aa were secreted with an efficiency similar to that of wild-type HBsAg. The HVR1 region exposed on the particles retained an antigenic structure similar to that recognized immunologically during natural infection. VLPs containing epitopes from either HCV-1a or -1b strains were produced that induced strain-specific antibody responses in immunized mice. Injection of a combination of these VLPs induced antibodies against both HVR1 epitopes that resulted in higher titers than were achieved by vaccination with the individual VLPs, suggesting a synergistic effect. This may lead to the development of recombinant particles which are able to induce a broad anti-HCV immune response against the HCV quasispecies or other quasispecies-like infectious agents.
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Printed copy of an undated abstract of laws and regulations with the admittatur of undergraduate Thomas B. Hall signed by President Josiah Quincy on August 25, 1840. The admittatur identifies Hall as a freshman.
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Mode of access: Internet.