Procès de Robert III d'Artois, comte de Beaumont.

Registre original. En tête du volume, notes de dom Poirier, concernant ce manuscrit et d'autres exemplaires du procès de Robert d'Artois. — Peintures (f. 2 r et v).

The Journey of Dr. Robert Bongout, and his lady, to Bath. : Performed in the year 177-.

A satire in verse on Dr. Robert Bragge, Cf. BM.

The Reverend Robert Stuart, D. D., 1772-1856, a pioneer in Kentucky Presbyterianism, and his descendants.

Mode of access: Internet.

Memoirs of the Rev. Robert Finley, D. D.,

Mode of access: Internet.

The life of the Rev. Robert Newton, D. D.

Mode of access: Internet.

Mus. Autogr. R. Schumann C001 - Efeublatt vom Grab Robert Schumanns (Ansetzungssachtitel von Bearbeiter/in)

"Ein Blatt von Robert Schumanns Grab gepflückt. Erhalten zu Bonn / 11.3.[18]59 / von Kapellmeister Peters."

Le Marquis de Pomponne, ambassadeur et secrétaire d'état, 1618-1699. Documents

The documents in the "Appendice" include letters between Pomponne and his father, Robert Arnauld d'Andilly.

L'Algérie : des moyens de conserver et d'utiliser cette conquête /

Mode of access: Internet.

Depth of focus and visual acuity with primary and secondary spherical aberration

It is known that the depth of focus (DOF) of the human eye can be affected by the higher order aberrations. We estimated the optimal combinations of primary and secondary Zernike spherical aberration to expand the DOF and evaluated their efficiency in real eyes using an adaptive optics system. The ratio between increased DOF and loss of visual acuity was used as the performance indicator. The results indicate that primary or secondary spherical aberration alone shows similar effectiveness in extending the DOF. However, combinations of primary and secondary spherical aberration with different signs provide better efficiency for expanding the DOF. This finding suggests that the optimal combinations of primary and secondary spherical aberration may be useful in the design of optical presbyopic corrections. © 2011 Elsevier Ltd. All rights reserved.

A typical migraine susceptibility region localizes to chromosome 1q31

Migraine (with and without aura) is a prevalent neurovascular disease that shows strong familial aggregation, although the number of genes involved and the mode of inheritance is not clear. Some insight into the disease has been gained from genetic studies into a rare and very severe migraine subtype known as familial hemiplegic migraine (FHM). In this study, we took a family-based linkage and association approach to investigate the FHM susceptibility region on chromosome 1q31 for involvement in typical migraine susceptibility in affected Australian pedigrees. Initial multipoint ALLEGRO analysis provided strong evidence for linkage of Chrlq31 markers to typical migraine in a large multigenerational pedigree. The 1-LOD* unit support interval for suggestive linkage spanned approximately 18 cM with a maximum allele sharing LOD* score of 3.36 obtained for marker D1S2782 (P=0.00004). Subsequent analysis of an independent sample of 82 affected pedigrees added support to the initial findings with a maximum LOD* of 1.24 (P=0.008). Utilising the independent sample of 82 pedigrees, we also performed a family-based association test. Results of this analysis indicated distortion of allele transmission at marker D1S249 [global chi2 (5) of 15.00, P=0.010] in these pedigrees. These positive linkage and association results will need further confirmation by independent researchers. However, overall they provide good evidence for the existence of a typical migraine locus near these markers on Chrlq3l, and reinforce the idea that an FHM gene in this genomic region may also contribute to susceptibility to the more common forms of migraine.