Vie de Félix Armand, curé de Saint-Martin-Lis, près de Quillan (Aude).

Mode of access: Internet.

Updated list of ant species (Hymenoptera, Formicidae) recorded in Santa Catarina State, southern Brazil, with a discussion of research advances and priorities

Updated list of ant species (Hymenoptera, Formicidae) recorded in Santa Catarina State, southern Brazil, with a discussion of research advances and priorities. A first working list of ant species registered in Santa Catarina State, southern Brazil was published recently. Since then, many studies with ants have been conducted in the state. With data compiled from published studies and collections in various regions of the state, we present here an updated list of 366 species (and 17 subspecies) in 70 ant genera in Santa Catarina, along with their geographical distribution in the seven state mesoregions. Two hundred and seven species are recorded in the Oeste mesoregion, followed by Vale do Itajaí (175), Grande Florianópolis (150), Norte (60), Sul (41), Meio Oeste (23) and Planalto Serrano (12). The increase in the number of records since 1999 results from the use of recently adopted sampling methods and techniques in regions and ecosystems poorly known before, and from the availability of new tools for the identification of ants. Our study highlights the Meio Oeste, Planalto Serrano, Sul and Norte mesoregions, as well as the deciduous forest, mangrove, grassland and coastal sand dune ecosystems as priority study areas in order to attain a more complete knowledge of the ant fauna in Santa Catarina State.

Abulfeda Tabula Syriae cum excerpto geographico ex Ibn ol Wardii Geographia et historia naturali, arabice nunc primum ed., latine vertit notis explanavit Io. Bernhardus Koehler, accessera io. Iacabi Reiskii Animadversiones ad abulfedam et Prodidagmata ad historiam et geographiam orientalem.

MTSD 7.

(Le) parlement de Paris de Philippe-le-Bel à Charles VII (1314-1422); son organisation.

Mode of access: Internet.

Mes voyages avec le docteur Philips dans les républiques de La Plata (Buenos-Ayres, Montevideo, La Banda-Oriental, etc.)

Armand de B * * * pseud. of J. J. E. Roy.

[Illustrations de Discours sur les monuments publics] / J. Molinos, J.G. Legrand, dess. ; Poulleau, grav. ; Armand-Guy-Simon de Coetnempren, Comte de Kersaint, aut. du texte

Comprend : [ Planche 1 ] Pritanée de la 1ère classe. [ Monument public républicain. XVIIIè siècle.] Dessinée par J. Molinos et Le Grand. Gravée par Poulleau. 1791. [ Cote : BNF C 103551. ] ; [ Planche 2. ] Pritanée de 2ème classe. [ Monument public républicain. XVIIIè siècle.] Dessinée par J. Molinos et Le Grand, gravée par Poulleau, 1791. [ Cote : BNF C 103552. ] ; [ Planche 3. ] Printanée de la 3ème classe. [ Monument public républicain. XVIIIè siècle.] Dessinée par J. Molinos et Le Grand, 1791. Gravée par Poulleau. [ Cote : BNF C 103553. ] ; [ Planche 4. ] Projet de pritanée à élever sur les ruines de la Bastille. [ Monument public républicain. XVIIIè siècle.] Dessinée par J. Molinos et Le Grand, 1791. Gravée par Poulleau. [ Cote : BNF C 103554. ] ; [ Planche 5. ] Projet d'une salle pour l'Assemblée Nationale dans les nouvelles constructions destinées à la Madeleine de la Ville l'Evêque. [ Monument public républicain. XVIIIè siècle.] Dessinée par J. Molinos et Le Grand, 1791. [ Cote ; [ Planche 6. ] Elévation du Palais National. [ Monument public républicain. XVIIIè siècle.] Dessinée par Le Grand et J.Molinos, 1791. Gravée par Poulleau. [ Cote : BNF C 103556. ] ; [ Planche 7. ] Plan général du Palais National. [ Monument public républicain. XVIIIè siècle.] Dessinée par Molinos et Le GRand, 1791. Gravée par Poulleau. [ Cote : BNF C 103557. ] ; [ Planche 8. ] Coupe de la longueur du Palais National. [ Monument public républicain. XVIIIè siècle.] Dessinée par Molinos et Le Grand. Gravée par Poulleau. [ Cote : BNF C 103558. ] ; [ Planche 9. ] Projet du Cirque National. [ Monument public républicain. XVIIIè siècle.] Dessinée par Molinos et Le Grand, 1791. Gravée par Poulleau. [ Cote : BNF C 103559. ] ; [ Planche 10. ] Projet du Museum, [ ancien Palais du Louvre. Monument public républicain. XVIIIè siècle.] Dessinée par Molinos et Le Grand, 1791. Gravée par Poulleau. [ Cote : BNF C 103560. ] ; [ Planche 11. ] Distribution du Louvre pour l'Institut National. [ Monument public républicain. XVIIIè siècle.] Dessinée par Molinos et Le Grand, 1791. Gravée par Poulleau. [ Cote : BNF C 103561. ] ; [ Planche 12. ] Plan général du Louvre et des Tuileries [ vers 1791. ] Dessinée par Molinos et Le Grand, 1791. [ Cote : BNF C 103562. ]

Hādhā kitāb al-Thaʻālib�� al-musammá bi-Riyāḍ al-ṣāliḥīn wa-tuḥfat al-muttaqīn : manuscript, 1742

بسم الله الرهمن الرحيم وصلى الله على سيدنا محمد وسلم هذا كتاب الثعالبي ... :Incipit

Molecular adaptability of nucleoside diphosphate kinase b from trypanosomatid parasites: stability, oligomerization and structural determinants of nucleotide binding

Nucleoside diphosphate kinases play a crucial role in the purine-salvage pathway of trypanosomatid protozoa and have been found in the secretome of Leishmania sp., suggesting a function related to host-cell integrity for the benefit of the parasite. Due to their importance for housekeeping functions in the parasite and by prolonging the life of host cells in infection, they become an attractive target for drug discovery and design. In this work, we describe the first structural characterization of nucleoside diphosphate kinases b from trypanosomatid parasites (tNDKbs) providing insights into their oligomerization, stability and structural determinants for nucleotide binding. Crystallographic studies of LmNDKb when complexed with phosphate, AMP and ADP showed that the crucial hydrogen-bonding residues involved in the nucleotide interaction are fully conserved in tNDKbs. Depending on the nature of the ligand, the nucleotide-binding pocket undergoes conformational changes, which leads to different cavity volumes. SAXS experiments showed that tNDKbs, like other eukaryotic NDKs, form a hexamer in solution and their oligomeric state does not rely on the presence of nucleotides or mimetics. Fluorescence-based thermal-shift assays demonstrated slightly higher stability of tNDKbs compared to human NDKb (HsNDKb), which is in agreement with the fact that tNDKbs are secreted and subjected to variations of temperature in the host cells during infection and disease development. Moreover, tNDKbs were stabilized upon nucleotide binding, whereas HsNDKb was not influenced. Contrasts on the surface electrostatic potential around the nucleotide-binding pocket might be a determinant for nucleotide affinity and protein stability differentiation. All these together demonstrated the molecular adaptation of parasite NDKbs in order to exert their biological functions intra-parasite and when secreted by regulating ATP levels of host cells.

Titulação de aloanticorpos anti-a e anti-b em gatos domésticos sem raça definida em Porto Alegre, Rio Grande do Sul, Brasil

A probabilidade de ocorrência de reação transfusional em um felino depende da prevalência local dos tipos sanguíneos felinos e dos títulos de aloanticorpos. A determinação dos títulos de aloanticorpos auxilia na estimativa do risco e da severidade de reação transfusional, após transfusão não compatível, em uma população de gatos. O objetivo deste trabalho foi determinar a titulação de aloanticorpos e o risco de possível reação transfusional, em felinos domésticos sem raça definida, da cidade de Porto Alegre. Foram selecionados aleatoriamente 100 gatos clinicamente saudáveis, sem raça definida e sem parentesco entre si e sem histórico de transfusão prévia. Amostras de sangue foram coletadas da veia jugular e a titulação de aloanticorpos foi determinada no soro de gatos com tipo sanguíneo previamente definido. O risco estimado foi calculado de acordo com estudos prévios. No presente trabalho, 82,5 e 100% dos gatos do tipo A e B, respectivamente, apresentaram titulação variada de aloanticorpos. Com base nos títulos encontrados, verificou-se que uma transfusão de sangue, do tipo A ou AB, em gatos do tipo B apresenta risco de 33,3% de reação aguda severa e de 66,7% de reação aguda leve, nos receptores felinos. A transfusão de sangue do tipo AB ou B em gatos do tipo A apresenta risco de reação aguda severa em 1,0%; reação aguda leve em 37,1% e destruição prematura dos eritrócitos em 44,3% dos receptores felinos.

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B

Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. a-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation coupled to molecular mechanics with generalized Born and surface area method energy decomposition on RNAP II. They were performed with a clinical drug that shares chemical similarities to a-amanitin, polymyxin B. The results show that polymyxin B potentially binds to RNAP II in the same interface of a-amanitin, preventing the toxin from binding to RNAP II. In vivo, the inhibition of the mRNA transcripts elicited by a-amanitin was efficiently reverted by polymyxin B in the kidneys. Moreover, polymyxin B significantly decreased the hepatic and renal a-amanitin-induced injury as seen by the histology and hepatic aminotransferases plasma data. In the survival assay, all animals exposed to a-amanitin died within 5 days, whereas 50 % survived up to 30 days when polymyxin B was administered 4, 8, and 12 h post-a-amanitin. Moreover, a single dose of polymyxin B administered concomitantly with a-amanitin was able to guarantee 100 % survival. Polymyxin B protects RNAP II from inactivation leading to an effective prevention of organ damage and increasing survival in a-amanitin-treated animals. The present use of clinically relevant concentrations of an already human-use-approved drug prompts the use of polymyxin B as an antidote for A. phalloides poisoning in humans.

The Epidemiological Impact of Antimeningococcal B Vaccination in Cuba

The incidence of invasive meningococcal disease (IMD) before (1984-1988) and after (1989-1994), a nationwide intervention with VA-MENGOC-BC vaccination started in 1989, was compared. The prevaccination period incidence density (ID> 8.8/ 105 year-person) was higher than the postvaccination ID (ID< 6.5/ 105 year-person). The percentage proportional differences from the start to the end of each period of ID in the vaccinal period was higher (87%) than the prevaccinal (37%) with significant differences among vaccinated groups (< 25 years old). A break-point (Chow test) was confirmed by the decrease in the ID between 1989 and 1990 in children under 1 year old, 5-9, 10-14, 15-19 and 50-54 years. Comparison of ID using maps showed a decrease in IMD in all municipalities during the postvaccination period. These findings support the epidemiological impact of VA-MENGOC-BC vaccination in the reduction of IMD morbidity.